1.Evaluation of the Ventricular and Pulmonary Function During One-lung Ventilation in Penumonectomy
Bo ZHANG ; Xuequan LUO ; Wen ZHANG
Journal of Chinese Physician 2001;0(08):-
Objective To investigate the relationship of ventricular and pulmonany function in preoperation,perioperation and postoperation in penumonectomies.Methods FEV 1%,FVC% and treadmill exercise test of preoperation and postoperation were compared.SPO 2 and ECG of preoperation,perioperation and postoperation also were compared.To give airway oxygen during good-lung ventilation in operation in 43 patients.Results Findings of obove mentioned markers measurement in preoperation,perioperation and postoperation at one week,three months were shown the pulmonary function of postoperation was changed appearently when FEV 1%
2.The hemangioma of alimentary tract
Zulin CHEN ; Xuequan HUANG ; Zhitang SHAN ; Yunsheng LUO ; Deshan GAO ;
Chinese Journal of General Surgery 1994;0(05):-
Eighteen patients with hemangioma of alimentary tract were treated in our hospital from 1980 to 1994 There were 11 males and 7 females,with average age of 48?18 years (ranged from 19 to 76 years) Of them,14 patients were treated with operation,2 with hemangioma of rectum were treated with ligation with snare.All of the 16 patients were cured. The etiology,pathology,diagnosis and management are discussed in this paper The experiences of finding small hemangiomas of jejunum and ileum during operation are also introduced in the paper
3.Effects of early enteral nutrition on prognosis of patients with sustained esophageal caner
Bo ZHANG ; Wen ZHANG ; Xuequan LUO ; Shengting QIANG ; Zhiyi ZHAO ; Huazeng CHEN ; Guoming XIAN ; Feng ZHANG
Chinese Journal of Primary Medicine and Pharmacy 2008;15(8):1313-1314
Objective To investigate the effect of early enteral nutrition.Methods 248 patients with esophageal and gastric carcinoma were randomly divided into two groups,and received enteral nutrition(EN)and parenteral nutrition(PN)each continuously for 6 days after operation.The body weight,blood routine test,liver function,and postoperative day 8 were compared with those before operation.Results The body weight,red blood cell count,and the levels of hemoglobin,serum albumin and transaminase decreased less in EN group than those in PN group(P<0.01).The complication rates of anastomotic fistula,pulmonary infection,and delayedincision healing and average volume of pleural effusion were 0,13.8%,0,780ml in EN groups,while 3.2%,28.2%,7.2%,1842ml in PN group.Conclusion Early postoperative enteral nutirtion after esophageal carcinoma surgery can improve nutritional status and reduce complications in comparision with parenteral nutrition.
4.Suppressive effect of resveratrol on growth of U251 human glioma cells and its correlated mechanism.
Hongsheng LIU ; Jinhuan WANG ; Xinnv XU ; Na LIN ; Biao ZHANG ; Xuequan FENG ; Zhongqiu LUO
China Journal of Chinese Materia Medica 2009;34(8):1027-1031
OBJECTIVETo investigate the suppressive effect of resveratrol on growth of U251 human glioma cells and its correlated mechanism.
METHODU251 human glioma cells were treated with resveratrol at various concentrations, MTT assay was used to determine the inhibitory rate of cell proliferation, FCM to detect the cell apoptosis, the expressions of Bcl-2, Bcl-XL, STAT3 and CyclinD1 were analysed by immunohistochemistry and Western blot to examine the expression of Bcl-2, Bcl-XL, STAT3, CyclinD1, Caspase-3 and Bax.
RESULTAfter treatment with resveratrol, MTT assay showed the growth of U251 cells was inhibited in dose-dependent and time-dependent manners, apoptosis of cells advanced stage was built up, immunohistochemical staining displayed decreased the expression of Bcl-2, Bcl-XL, STAT3 and CyclinD1 and Western blot showed that resveratrol decreased the expression of Bcl-2, Bcl-XL, STAT3 and CyclinD1, and built up Bax and Caspase-3.
CONCLUSIONIt is possible that downregulated the expression of Bcl-2, Bcl-XL, but upregulated Bax and Caspase-3, and the indication was obviously in dose-dependent and time-dependent manners.
Apoptosis ; drug effects ; Blotting, Western ; Caspase 3 ; metabolism ; Cell Line, Tumor ; Cyclin D1 ; metabolism ; Gene Expression Regulation, Neoplastic ; drug effects ; Glioma ; drug therapy ; metabolism ; Humans ; Immunohistochemistry ; Proto-Oncogene Proteins c-bcl-2 ; metabolism ; STAT3 Transcription Factor ; metabolism ; Stilbenes ; therapeutic use ; bcl-2-Associated X Protein ; metabolism ; bcl-X Protein ; metabolism