Objective To evaluate the efficacy of community management of asymptomatic hyperuricemic patients.Methods Two hundred and six patients with asymptomatic hyperuricemia in Yuetan community of Beijing were randomly and equally divided into study group and control group.Patients in study group received 12-month standardized management, while those in control group were given conventional management.After 12 months of intervention, the clinical data and related information were analyzed and the effect of intervention was evaluated by questionnaire survey.Results After 12-month intervention, the rates of unhealthy lifestyle in intervention group were significantly lower, and the exercise time was significantly more than those in control group [drinking:frequently 8.7%(9/103)vs.11.7%(12/103),seldom 83.5% (86/103) vs.68.9% (71/103),χ2=7.005, P=0.030;eating animal offal: seldom 88.4%(91/103) vs.76.7%(79/103),frequently 1.9%(2/103) vs.8.7%(9/103),χ2=6.302, P=0.043;eating seafood: seldom 74.8%(77/103) vs.52.4%(54/103),frequently 4.8%(5/103) vs.16.5%(17/103),χ2=12.867, P=0.002;eating thickened gravy: seldom 78.6%(81/103)vs.53.4%(55/103),frequently 2.9%(3/103) vs.13.6%(14/103),χ2=16.334, P=0.000;exercise time: seldom 17.5%(18/103)vs.24.3%(25/103),1-3 h 26.2%(27/103) vs.38.8%(40/103),4-6 h 32.0% (33/103) vs.20.4%(21/103), ≥7 h 24.3%(25/103) vs.16.5%(17/103),χ2=7.852, P=0.049].The blood uric [(403±54) vs.(474±71) μmol/L], cholesterol [(4.6±0.8) vs.(4.9±1.0)mmol/L], triglyceride[(1.65± 0.54) vs.(1.86±0.86) mmol/L] and systolic pressure [(128±10) vs.(131±14) mmHg(1 mmHg=0.133 kPa)] in intervention group significantly lower than those in control group (t=7.984,P=0.000;t=2.803,P=0.006;t=2.130,P=0.034;t=2.059,P=0.041).The awareness rate of hyperuricemia-related knowledge in intervention group was significantly higher than that in control group [85.1% (964/1 133) vs.45.5%(516/1 133), χ2=390.959,P=0.000].Conclusion Standardized community management is effective for patients with asymptomatic hyperuricemia.

Objective To survey the awareness of hyperuricemia in patients and medical personnel in Yuetan community.Methods By using random sampling method, 492 patients with hyperuricemia and 84 medical personnel in Yuetan community were selected for questionnaire survey.Results The rate of awareness of hyperuricemia in patients was 33.2%(1 472/4 428), and 95.5%(470/492)of them had the requirement of health education on hyperuricemia.The awareness rate of hyperuricemia in medical personnel was 73.0%(736/1 008), and 46.4%(39/84) of them thought health education on hyperuricemia as important or very important.Conclusion The awareness of hyperuricemia is insufficient in patients and medical personnel.Health education should be reinforced for community management on hyperuricemia.

Objective To study the clinical value of analyzing lipids indexes in patient with coronary heart disease(CHD).Methods seventy nine patients were chosen to CHD group;health group contain 70 people.Levels of lipids indexes were measured,the ROC curve was used to comparison and analysis.Results There were significantly difference in Lp(a)、TC、TG、HDL-C、ApoA1 and A1/B(P0.7 and had significant difference(P

Objective To understand the prevalence rate of mild cognitive impairment (MCI) and its related factors in community elderly so as to provide evidence for the community intervention. Methods A cross-sectional study was performed in a random sampling of 925 elderly people. Mini-mental state examination (MMSE), activities of daily living (ADL) scale and questionnaire were used for face-to-face interview. Chi-square test and logistic regression analysis were applied in this study. Results The prevalence rate of MCI was 21.1% in elderly people. Female, high age, illiteracy, loss of spouse, lack of exercise, no professional activitives and not doing some work for the descendants were the risk factors for MCI. Conclusions The aging and the low educational level are the risk factors for MCI in the elderly. High self-care ability scores are the protective factors for MCI.

Objective To detect the impact of ultrasound elastography in diagnosis of prostatic cancer,and to evaluate its capability in differentiating benign from malignant lesions.Methods From June 2013 to February 2015, we selected 50 patients with different prostatic lesions,and suspicious for malignancy were included.All patients had a conventional B-mode ultrasound examination and color Doppler imaging,and then real time ultrasound elastography was performed in the same session.Finally,the results were compared to the histopathological results of those lesions. Results The addition of Strain ratio parameter for evaluating the elastography images showed the highest sensitivity of 74.2%,specificity of 73.7% and accuracy of 74.0% at a best cut off point of 5.5 between benign and malignant lesions.Conclusion Prostate US combined with elastography can be a helpful tool for guiding malignant lesions.Also it can help in targeting the biopsy site.

Objective To analyze the telephone follow-up response rate and related factors in lung cancer patients thus to explore the countermeasures to increase the telephone response rate.Methods One thousand six hundred and eight post-surgery lung cancer patients were followed up by telephone interview,calculate response rates and analyze the impact factors on response rates of surgical patients. Results The lung cancer patients' overall response rate of one thousand six hundred and eight cases was 83.1%.Reservation phone type, phone number,family history of cancer are major factors affecting lung cancer patients' telephone followed up response rate(P<0.05). Conclusions Telephone follow-up of patients with lung cancer response rates is at a low level.To improve tumor response rates of follow-up and follow-up quality is a long and arduous task,requiring medical personnel continue to learn professional knowledge,summing up a reasonable follow-up methods,but also needing patients and their families to understand and cooperate.

ObjectiveTo explore the effect of tracer methodology on management of high-risk medicine.Methods The management of high-risk medicine was investigated with tracer methodology to find out the problems in the medicine management, construct effective management system and establish tracer programme and pyramid management mode for high-risk medicine management.The rate of adverse events in high-risk medicine management before the use of tracer methodology was compared with that after the use.Result The incidence of adverse events was significantly lower than that before the use of tracer methodology (χ2=5.379,P<0.05).Conclusion The tracer methodology in the management of high-risk medicine can be effective in the reduction of incidence of adverse events in high-risk medicine management and promotion of safety management.

Objective To study the effects of Valsartan on oxidative stress in brain tissue of diabetic rats.Methods Diabetic Wistar rats were induced by streptozotocin(STZ) and were randomly divided into diabetic group and Valsartan treatment group.In Valsartan treatment group,the rarts received Valsartan 40 mg/(kg?d) for 12 weeks by intragastric administration.Then blood glucose and body weight were measured.The cognition ability of rats was assayed with Morris water maze test.The activities of superoxide dismutase(SOD),maleic dialdehyde(MDA) and hydroxy radical(OH-) were detected by chromatometry.Quantitative real-time RT-PCR was performed to detect the expression of NADPH oxidase p47phox mRNA.Results(1) Compared with normal control group,the body weight in diabetic group and Valsartan treatment group decreased significantly(both P

Objective To explore the clinical effect and safety of Wenxin granule combined with metoprolol on arrhythmia in elderly patients with coronary heart disease (CHD).Methods 186 elderly CHD patients with arrhythmia were divided into 3 groups according to therapy:group A (n=62,treated with Wenxin granule),group B (n=60,treated with metoprolol) and group C (n=64,treated with Wenxin granule plus metoprolol).Clinical effect and adverse effect were retrospectively analyzed.Results The excellence rate and total efficiency rate were higher in group C than group A andB [53.1％ (34 cases) vs.32.3％ (20 cases),30.0％ (18 cases); 93.8％ (60 cases) vs.40.3％ (25 cases),40.0％ (24 cases) ; respectively,all P＜0.05].There were no significant differences in the incidence of adverse effect in the 3 groups [4.8％ (3/62),8.3％ (5/60) vs.8.3％ (5/64),all P ＞0.05].Conclusions Wenxin granule combined with metoprolol improves clinical effect,decreases premature beat and has a better safety for elderly CHD patients with arrhythmia,which is worthy of clinical application.

Objective To investigate the effect of the activity of CR1, the expression of CD_ 58 , the level of soluble interleukin-2R (SIL-2R) and interleukin-6(IL-6) level in serum on obstructive sleep apnea syndrome (OSAS). Methods Select 20 OSAS cases in hospital and 15 healthy controls of the same age. Use flow cytometry and enzyme-linked immunosorbent assay(ELISA) to detect the activity of CR1, the expression of CD_ 58 and the level of SIL-2R, IL-6 in serum. Results (1)The erythrocytes cancer cell rosette(ECR1CaRR)of the OSAS group was lower than that of control group(P0.05). There were significant positive dependability between the level of SIL-2R,IL-6 in serum and SIT90(P0.05). Conclusions There are relations between the level of SIL-2R,IL-6 in serum and the condition of OSAS cases, which can be used to evaluate and define in clinical work,there is a accommodative role between erythrocyte immune function and some cytokines.