Objective To explore the change of plasma orexin-A levels in patients with chronic obstructive pulmonary disease(COPD).Methods Lung function test and blood gas analysis were performed in 15 obese COPD patients,20 COPD patients without obesity,20 obese controls and 20 normal healthy adults(control group).In both obese COPD group and obese group,the body mass index(BMI)was higher than 25 and there was no significant difference in BMI.The plasma was deproteinized by chromatography,and the plasma orexin-A levels were determined by radioimmunoassay.Results The plasma orexin-A levels in the obese COPD group[(8.82?1.90)ng/L]and the non-obese COPD group[(8.69?1.84)ng/L]were significantly higher than those in the obese group[(7.18?1.45)ng/L(P 0.05).Plasma orexin-A levels in patients with COPD correlated negatively with partial pressure of oxygen(PaO_2)(r = -0.527 ,P

Objective To investigate the effect of low molecular weight heparin calcium combined with breviscapini in treating a-cute exacerbation of elderly chronic pulmonary heart disease and its mechanism.Methods 86 patients with acute exacerbation of elderly chronic pulmonary heart disease in our hospital from October 2011 to June 2013 were randomly divided into two groups. There were no significant differences in age,gender and disease condition between the two groups.44 cases were in the therapy group and the other 42 cases were in the control group.Both two groups received the routine therepy.On this basis the therapy group was added with low molecular weight heparin calcium and breviscapini.Then the improvement of clinical symptoms and the changes of plasma nitric oxide (NO)and endothelin-l (ET-1)after treatment were observed in the two groups.Results The total effective rates in the therapy group and the control group were 90.1%and 71.4% respectively;the levels of plasma NO and ET-1 after treatment in the two groups were significantly improved,but the improvement in the therapy group was better than that in the control group with the statistical difference between them(P <0.05).Conclusion Low molecular weight heparin calcium combined with breviscapini can significantly improve the symptoms in the ederly pulmonary heart disease,decrease the lung arterial press,re-lieve the load of right ventricle and affect the levels of plasma NO and ET-1 with less adverse reactions.

Objective To explore the clinical therapeutic effect of combined treatment of low molecular weight heparin calcium and breviscapine in elder pulmonary heart disease .Methods 303 patients in elder pulmonary heart disease in the hospital from May 2011 to June 2013 were divided into three groups .100 patients in group A were received the routine therepy ,102 patients of group B were received routine therapy combined with low molecular weight heparin calcium only ,101 patients of group C were received routine therapy combined with low molecular weight heparin calcium and breviscapine .the changes of clinical symptom ,blood gas a-nalysis ,hemorheology in groups before and after treatment were observed .Results The effective rates of group A ,B ,C were 59 .0% ,73 .5% and 90 .0% ,the results showed that the blood gas analysis and hemorheology parameter in groups B and C had more improved than group A (P<0 .05) ,and better in group C than group B(P<0 .05) .Conclusion The combined treatment of low molecular weight heparin calcium and breviscapine can decrease the press of lung artery ,relieve the bear of right ventricle and improve the arterial partial pressure of oxygen ,mean pulmonary arterial pressure and hemorheology parameter ,and has less adverse reaction .

Objective To form the basis of establishing a strategy for safe blood donor recruitment and to identify and subdivide the structures of donors.Methods Demographic data of blood donors, and blood testing results of HBsAg, anti-HCV, anti-HIV, and syphilis, from Nov. 2004 to Jun. 2005, were collected and analyzed.Results Among the 45270 voluntary blood donors, the total positive test rate were 3.11%, which was related to age, level of education and occupation of blood donors. About 76.7% of donors were young people, aged from 18 to 30. As the age increased, female donors were less than male ones. Among all the donors, 81.6% received higher education, which had lower positive test rate than those with lower level of education. Among the 45270 donors, farmers had the highest positive test rate; workers and service people came the second; students and medical staff had the lowest. As to donors with incomplete record, the positive test rate was higher than those with complete record.Conclusion During blood donor recruitment, quality control is important. People younger than 30, with student or higher education background, are relatively safe to recruit.

Objective To find out factors influencing voluntary blood donation activities and establish the most appropriate method for recruiting blood donors. Methods Questionnaire investigation of donors and data analysis by SPSS+ software. Results In Chengdu city, 2385 residents' knowledge on nonrenumerated blood donation was as follows: among the 2385 residents, the percentage of people who knew the government policies of blood donation was high (87.5%), but the percentage having common knowledge of blood donation was only 29.4%, of risk behavior was 32.5%. Among the 1349 participants who had donated blood, the percentages having common knowledge of blood donation and risk behavior were 33.4% and 38.1% respectively, compared to the 1036 participants who never donated (24.2% and 25.1%, respectively)(P

Objective To investigate the relationship between myeloperoxidase(MPO) and ankle brachial index(ABI) in patients with htypehypertension.Methods A total of 133 patients were enrolled in this study,and divided in to htypehypertention group(n=72),non-htypehypertension group(n=30) and normotension group(n=31).Their Hcy,ABI and MPO levels were measured and compared.Results The ABI in htypehypertention group and non-htypehypertension was significantly lower than that in normotension group (P<0.05),ABI in non-htypehypertension group was lower than that of htypehypertonsion group(P<0.05).MPO and CRP in the htypehypertension group was significant higher that those of normotension group(P<0.05).The ABI was negatively related with the serum MPO and CRP levels in htypehypertention group (r=-0.712,-0.722,P<0.05).Conclusion ABI is closely related with MPO,and play an important role in diagnosis of artery function impairment and high risk of htypehypertension patients.

Objective To assess the quality of randomized controlled trials (RCTs) of delirium prevention of elderly published in China.Methods The literatures from China National Knowledge Infrastructure(CNKI),WANFANG Data and VIP Database for Chinese Technical Periodicals were evaluated according to Cochrane collaboration's tool for assessing risk of bias and Jadad scale.Results A total of 53 RCTs were included,14 (26.4％,14/53) described radom number table used to generate the random allocation sequence,4 (7.5％,4/53) conducted experiments in a blinded manner,7 (13.2％,7/53) did not use intentionto-treat to analyse those who did not complete the study,9 (17.0％,9/53) had high risk of other bias,none described allocation concealment mechanism and blinding to participants and intercention implementers.Based on Jadad scales,the score was 1-4,average score was (2.3±0.8),19 (35.8％,19/53) were high-quality literatures.Conclusions The quality of present published literatures is not high,the further domestic studies should be designed high-quality to better improve clinical practice.

The experimental teaching of Pharmaceutical Technology plays a critical role in improving the students' knowledge conversion,application,and innovation abilities in pharmaceutical engineering specialty.According to the problems existing in experimental teaching process,exploration and practice on the case teaching method and the student-centered teaching mode are introduced in this paper.The implementation of the teaching reform can effectively combine pharmaceutical technology theory with practice,and is conducive to the professional development of pharmaceutical engineering in our university.

Objective To investigate and analyze the clinical application of washed red blood cells in Quzhou in 2014-2015 years,and to provide evidence for the rational and effective use of washed red blood cells in clinical practice.Methods the amount of washed red blood cells,the distribution of diseases and the serological detection before transfusion were analyzed retrospectively in 8 hospitals of grade two and over in Quzhou during the past 2014-2015 years.Results the amount of washed red blood cells in 2015 increased by 39.07％ compared with 2014,an increase of 24.4 times the amount of red blood cells increase,increase mainly in 3 hospitals;Diseases of the blood system,malignant tumors and chronic kidney disease is the main diagnosis of transfusion cases,accounted for 63.49％,19.05％,12.70％.There were different standards for the development of serological testing items before transfusion Conclusion the advantages of washed red blood ceils gradually recognized by clinicians,but also don't rely on experience,hospitals should pay attention to the comprehensive evaluation of clinical blood transfusion and standardize the serological detection of blood transfusion department,which is the key to improve the cost performance of this component.

ObjectiveTo investigate the plasma adiponectin in senile patients with coronary heart disease and NT -proBNP ex-pression and correlation . Methods 50 cases of coronary heart disease senile patients who were chosen ,were divided into acute myocardial infarction group (16 eases) ,not stable angina pectoris group (18 cases) ,stable angina pectoris group (16 cases) and normal group (50 cases) .The determination of plasma plasma adiponectin and NT-proBNP level were analyzed .Results Plasma adiponectin levels in senile patients with coronary heart disease group was obviously reduced ,and stable angina pectoris ,not stable angina pectoris ,acute myocardial infarction 3 group serum adiponectin in turn reduce ,the difference between groups was statistically significant(P< 0 .05) ;plasma NT-proBNP levels increased significantly ,and stable angina pectoris ,not stable anginapectoris ,acute myocardial infarction 3 group serum NT-proBNP increased in turn ,the deference between groups was statistically significant (P<0 .05) .APN level was correlated negatively with NT -proBNP(r= - 0 .236 ,P< 0 .05) .Conclusion There might be important value of APN and NT-proBNP for the prevention ,treatment and prognosis of coronary heart disease senile patients .