目的探讨健身秧歌舞对女性更年期综合征的缓解作用。方法对60名有更年期综合征症状的女性实施12周健身秧歌舞练习,分析受试者练习前后血清雌性激素水平及更年期综合征症状的变化。结果受试者血清雌二醇、孕酮含量提高(P<0.05),睾酮含量明显降低(P<0.01),更年期症状阳性率降低(P<0.05)。结论健身秧歌舞能有效缓解女性更年期综合征症状。

Pediatric sleep-disordered breathing, also known as obstructive sleep apnea and hypopnea syndrome (OSAHS) in children, is caused by obstruction of upper airway, characterized by repetitive pauses in breathing during sleep despite the effort to breathe, and usually leads to reduction in oxygen saturation. Due to the importance of sufficient oxygen in growth and development, many children patients suffer from abnormal secretion of growth hormone at night, and also their activity and resting of cerebral cortex during sleep. Therefore, they face great risks in keeping normal physical growth, forming mental behavior, building up learning ability and shaping personalities. It is a very important interdisciplinary subject, yet still much remains unclear about the disease. Oral medicine is one of the subjects that show increasing importance in prevention and treatment of OSAHS in children. On one hand, due to the special means of the field, such as cephalometric, it can diagnose and monitor the development of craniofacial structures, especially the upper airway. On the other hand, it can provide treatments which can both improve breath during sleep and consequent dental facial deformities. Most typical treatments include mandibular sagittal growth stimulation, transverse maxillary palatal expansion and maxillary protraction. Oral medicine provides additional treatment apart from traditional adenectomy and tonsilectomy to improve ventilation. It not only directly helps to improve deformities caused by sleep-disordered breathing in OSAHS children with indications, but also helps to avoid many of physical and mental complications, which will in turn benefit their life quality. Also, it may prospectively provide insights in treatment and prevention of OSAHS in adults.
Adult ; Cephalometry ; Child ; Humans ; Mandible ; Maxilla ; Palatal Expansion Technique ; Sleep Apnea Syndromes ; Sleep Apnea, Obstructive

The human Dab2 gene has a variety of physiological functions,and plays important roles in various signal transduction pathways.Researches have shown that reduced expression of Dab2 was closely related to the occurrence and development in many malignant cancers,and Dab2 has been regarded as a tumor suppressor.This paper reviewed about multiple researches on the structure and functions of Dab2,and explored the specific mechanisms in oncogenesis.

Objective To observe the clinical effect of singulair (montelukast sodium chewable tablets) combined with Zithromax(Azithromycin for Suspension) in treatment of children with asthma.Methods 86 children with asthma were randomly divided into control group and observation group,each group 43 cases,observation group was treated with singulair and zithromax,and control group was only treated with singulair.Before and after treatment,pulmonary function and clinical efficacy were observed.Furthermore,clinical symptoms disappearance time and the incidence of adverse reactions were also observed.Results After teratment,FEV1 and PEF in observation group were significantly higher than control group(P ＜ 0.05).The total effective rate in observation group and control group were 97.7％ and 88.9％,respectively.The difference between two groups was statistically significant(P ＜0.05).Observation group coughing,shortness of breath and wheeze and other symptoms disappeared time were shorter than the control group(P ＜ 0.05).Adverse reactions between the two groups had no significant difference (P ＞ 0.05).Conclusion Singulair combined with zithromax in the treatment of chronic pelvic inflammatory disease with a better therapeutic effect.It was worthy of clinical application.

Objective: To analyze the capability to overcome the major outbreak of epidemics in different regions of China, it supports the future public health emergency management stratigies in theory and technology. Methods: Based on the data of 31 regions of China, it evaluates the social vulnerability of two major epidemics (SARS in 2003 and H1N1 influence in 2009) by using factor analysis method. Results: In the middle and eastern regions of China, social vulnerability is relatively low, and comparing to SARS in 2003, it decreases in 2009; while the western and southwesternregions are the opposite. Conclusion: Infrastructure construction of health institution, the cultivation of medical and health personnel and the development of commercial health insurance are the key factors to reduce social vulnerability and enhance the ability of emergency.

Objective To observe the effect of low-dose dexamethasone in the treatment of neonatal meconium aspiration pneumonia and its influence on inflammatory cytokines.Methods 60 cases with neonatal meconium aspiration pneumonia were randomly divided into observation group and control group,30 cases in each group.The control group was given conventional treatment,the observation group was given low-dose dexamethasone treatment on the basis of the control group.Both groups had been treated for 3d,first ld 0.5mg/kg,2d 0.25mg/kg,3d 0.1 mg/kg.After 7 days,blood gas indicators and serum IL-6,IL-8,TNF2awere detected,the clinical efficacy was evaluated,the time of oxygen requirement and length of stay were recorded.Results The total effective rate of observation group and control group was 96.67％ (29/30) and 76.67％ (23/30) (x2 =6.497,P ＜ 0.05).The indicators of the observation group were significantly better than the control group,the average oxygen total time of the observation group and the control group was (6.1 ± 1.7) d and (10.2 ± 2.4) d (t =5.673,P ＜ 0.01).IL-6,IL-8,TNF2a of observation group and control group after treatment were (1.21 ±0.16) μg/L vs(3.07 ±0.24) μg/L,(1.13 ±0.14) μg/L vs (2.42 ± 0.33) μg/L,(2.61 ± 0.24) vs (4.07 ± 0.41) (all P ＜ 0.01).Conclusion The low-dose dexamethasone can reduce inflammatory cytokines levels and lung inflammation reaction,improve gas exchange,shorten the the aerobic time and the length of hospital stay,improve the short-term effect.

By destroying tumor vessels or directly killing tumor cells, high-intensity focused ultrasound ( HIFU) kills tumors or reduces tumor volume and decreases metastasis,lessens patients pain in advanced stage tumors and improves patients life quality. HIFU in combination with other therapies can kill more tumor cells, reduce long-term recurrence rate and achieve synergetic effect. HIFU therapy has many advantages, such as little trauma, small side effects and repeatable treatment and so on.

OBJECTIVE:To observe the efficacy of Ruzengxiao in the prevention and cure of hyperplasia of mammary glands in rats.METHODS:To investigate the therapeutic effect of drugs,the spayed rats were injected i.m with benzoic acid E2 0.8mg? kg-1 qd alt for 90 consecutive days,during the period between 20 and 30 days after modeling,these rats were injected with progesterone 4mg? kg-1 qd alt for 5 consecutive times;30d after modeling,the model animals with hyperplasia of mammary glands were randomized to groups to be treated intragastrically with 0.05% CMC-Na,Ruzengxiao or Tomoxi fen qd for 60d consecutively.Samples were taken at 24h after the last time of drug administration for determination of indexes.RESULTS:After treating the model animals for 2months,the following experimental results were obtained:for the spayed animals,after injection with estradiol(E2)for 3mo,their index of thymus decreased,indexes of uterus and adrenal glands increased significantly;levels of estrogen receptor(ER)in mammary tissues and serum E2 increased significantly,while the serum progesterone(P)deceased significantly,ratio of E2/testosterone(T)increased significantly;the numbers of lobules of mammary gland increased,hyperplasia of interstitial tissues appeared,secretion of acini increased,and the acini were highly distended,level of prolactin(PRL)increased,while levels of luteinizing hormone(LH)and follicle stimulating hormone(FSH)decreased,but no statistic difference was noted as compared with castration group(spayed animal without administration with E2 and P etc.);the E2-induced increase in indexes of uterus and adrenal gland was significantly inhibited after treatment with Tamoxifen or Ruzengxiao 20g? kg-1 for 2mo;Both Ruzengxiao(at different dosage)and Tomoxifen could significantly increase serum Testosterone level but decrease ratio of E2/T in rats with hyperplasia of mammary glands,showing significant differences as compared with model group.All drugs showed no obvious effect on serum levels of LH,FSH,PRL,P and E2 etc in rats with hyperplasia of mammary glands.CONCLUSION:The above results reveal that Ruzengxiao has satisfactory preventive and curative effects on model rats with hyperplasia of mammary glands.This mechanism might be related to the reduction of serum levels of E2,P and PRL,and the ratio of E2/T.

OBJECTIVE:To discuss the general pattern and characteristics of adverse drug reactions (ADR) induced by rabies vaccine. METHODS: A total of 156 ADR cases induced by rabies vaccine were retrieved from China Hospital Digital Library and China Pharmaceutical Abstract between Jan. 1995 and Nov. 2008 and analyzed statistically. RESULTS: The ADR induced by rabies vaccine were more often seen in females aged from 1 year to 40 years. 43.59% occurred within 30 minutes after medication;94.87% manifested as allergies,and allergic shock was even noted in serious cases. CONCLUSION: Great importance should be attached to the ADR induced by rabies vaccine to ensure medication safety.

Cerebral smal vessel disease (CSVD) refers to various diseases of brain perforating arterioles, capilaries and venules caused syndrome of clinical, cognitive and pathological manifestation. It is not only the main cause of stroke, but also causes cognitive impairment and dementia. Its pathogenesis is not fuly understood. Many studies have confirmed that endothelial dysfunction plays an important role in the pathogenesis of CSVD. This article review s the relationship between endothelial dysfunction and CSVD in order to provide new ideas for etiology, pathogenesis, and clinical prevention and treatment of CSVD.