60 cases of acne were treated by applying the collateral-pricking and cupping on Dazhui (GV 14), Feishu (BL 13), Ganshu (BL 18), Xinshu (BL 15) and Geshu (BL 17), in combination with herbal medicine. After two courses of the treatments, the results showed cure in 42 cases, effect in 18 cases, the curative rate in 70% and the total effective rate in 100%.

Of B cells derived from bone marrow hematopoictic stem cells,bone marrow (poultry,as the bursa of fabricius) is a place of B cells development and mature.The growth of B cells can experience from progenitor cell B,pre-B cells,immature B ceils and mature B cells stages in the bone marrow.The differentiation process of B cells can be divided into antigen independ stage and antigen depend stage.CD5 + B1 cells and B10 cells of B cell subsets probably associated with autoimmune disease,B1 cells may play roles of promotion in inflammatory reaction,and B10 cells may suppress autoimmune inflammation.

It is very difficult to make diagnosis on pediatric rheumatic diseases,because of the great variety of the diseases,being unclear of the etiology and pathogenesis,the complex clinical manifestations involving multiple organ damages.Knowing the classification of pediatric rheumatism,training of thought on systemic diagnosis,exception of infection and tumors,and combining with necessary examinations,might be made correct diagnosis.

Objective To explore the clinical efficacy of back acupoint pricking and cupping combined with intense pulsed light in the treatment of acne vulgaris.MethodsTotally 160 cases of acne vulgaris treated in our hospital from July 2014 to August 2015 were selected and randomly divided into observation group and control group, 80 cases in each group. Patients in both groups were treated with intense pulsed light, every two weeks, for 4 times. Patients in the observation group were treated with back acupoint pricking and cupping based on the treatment above, every other day, five times as a treatment session, for two sessions. The treatment efficacy was compared between the two groups.ResultsThe total effective rate in the observation group was 96.25% (77/80), which was significantly higher than 77.50% (62/80) in the control group, with statistical significance (P<0.01). Serum T of the two groups after the treatment decreased significantly when compared with those before the treatment. Serum T in the observation group in patients of the same sex decreased significantly after the treatment compared with those in the control group (P<0.01). Total scores of self-perception, emotion function and Qol-Acne score after treatment in observation group were significantly higher than those in the control group (P<0.01). After 3 months of treatment, the recurrence rate of the effective patients in the observation group was 2.60% (2/77), lower than the control group, which was 16.13% (10/62) with significant difference (P<0.01).Conclusion The clinical efficacy of back acupoints pricking and cupping combined with intense pulsed light in the treatment of acne vulgaris is confirmative, which can effectively reduce androgen levels and improve the life quality of patients, with low recurrence rate.

OBJECTIVE:To discuss the general pattern and characteristics of adverse drug reactions (ADR) induced by rabies vaccine. METHODS: A total of 156 ADR cases induced by rabies vaccine were retrieved from China Hospital Digital Library and China Pharmaceutical Abstract between Jan. 1995 and Nov. 2008 and analyzed statistically. RESULTS: The ADR induced by rabies vaccine were more often seen in females aged from 1 year to 40 years. 43.59% occurred within 30 minutes after medication;94.87% manifested as allergies,and allergic shock was even noted in serious cases. CONCLUSION: Great importance should be attached to the ADR induced by rabies vaccine to ensure medication safety.

OBJECTIVE:To provide reference for clinical rational drug use. METHODS:Combined with bacterial drug resis-tance monitoring data in our hospital in 2014,the varieties,the amount of antibacterial drug,DDDs and other index were analyzed retrospectively for the same period. RESULTS:The detection rate of Gram-negative bacteria (79.27%) was higher than that of Gram-positive bacteria (20.73%);the most common Gram-negative bacilli and Gram-positive cocci were Escherichia coli (38.62%) and Staphylococcus aureus (5.22%). Pseudomonas aeruginosa and Stenotrophomonas maltophilia were the most com-mon non-fermentation bacteria;Main Gram positive bacteria were most sensitive to vancomycin,tigecycline and furadantin,etc. Main Gram-negative bacteria were most sensitive to imipenem,ertapenem,etc. Top 3 antibacterial drug in the list of DDDs were Levofloxacin injection,Cefazolin injection,Cefoperazone/sodium sulbactam for injection. CONCLUSIONS:Third generation of cephalosporins are used frequently in our hospital,which is a major cause of ESBLs producing and drug resistance,bacterial drug resistance monitoring and early warning data has played a positive role on guiding reasonable application of antibacterial drug in our hospital.

Cerebral smal vessel disease (CSVD) refers to various diseases of brain perforating arterioles, capilaries and venules caused syndrome of clinical, cognitive and pathological manifestation. It is not only the main cause of stroke, but also causes cognitive impairment and dementia. Its pathogenesis is not fuly understood. Many studies have confirmed that endothelial dysfunction plays an important role in the pathogenesis of CSVD. This article review s the relationship between endothelial dysfunction and CSVD in order to provide new ideas for etiology, pathogenesis, and clinical prevention and treatment of CSVD.

OBJECTIVE:To observe the efficacy of Ruzengxiao in the prevention and cure of hyperplasia of mammary glands in rats.METHODS:To investigate the therapeutic effect of drugs,the spayed rats were injected i.m with benzoic acid E2 0.8mg? kg-1 qd alt for 90 consecutive days,during the period between 20 and 30 days after modeling,these rats were injected with progesterone 4mg? kg-1 qd alt for 5 consecutive times;30d after modeling,the model animals with hyperplasia of mammary glands were randomized to groups to be treated intragastrically with 0.05% CMC-Na,Ruzengxiao or Tomoxi fen qd for 60d consecutively.Samples were taken at 24h after the last time of drug administration for determination of indexes.RESULTS:After treating the model animals for 2months,the following experimental results were obtained:for the spayed animals,after injection with estradiol(E2)for 3mo,their index of thymus decreased,indexes of uterus and adrenal glands increased significantly;levels of estrogen receptor(ER)in mammary tissues and serum E2 increased significantly,while the serum progesterone(P)deceased significantly,ratio of E2/testosterone(T)increased significantly;the numbers of lobules of mammary gland increased,hyperplasia of interstitial tissues appeared,secretion of acini increased,and the acini were highly distended,level of prolactin(PRL)increased,while levels of luteinizing hormone(LH)and follicle stimulating hormone(FSH)decreased,but no statistic difference was noted as compared with castration group(spayed animal without administration with E2 and P etc.);the E2-induced increase in indexes of uterus and adrenal gland was significantly inhibited after treatment with Tamoxifen or Ruzengxiao 20g? kg-1 for 2mo;Both Ruzengxiao(at different dosage)and Tomoxifen could significantly increase serum Testosterone level but decrease ratio of E2/T in rats with hyperplasia of mammary glands,showing significant differences as compared with model group.All drugs showed no obvious effect on serum levels of LH,FSH,PRL,P and E2 etc in rats with hyperplasia of mammary glands.CONCLUSION:The above results reveal that Ruzengxiao has satisfactory preventive and curative effects on model rats with hyperplasia of mammary glands.This mechanism might be related to the reduction of serum levels of E2,P and PRL,and the ratio of E2/T.

By destroying tumor vessels or directly killing tumor cells, high-intensity focused ultrasound ( HIFU) kills tumors or reduces tumor volume and decreases metastasis,lessens patients pain in advanced stage tumors and improves patients life quality. HIFU in combination with other therapies can kill more tumor cells, reduce long-term recurrence rate and achieve synergetic effect. HIFU therapy has many advantages, such as little trauma, small side effects and repeatable treatment and so on.

Pediatric sleep-disordered breathing, also known as obstructive sleep apnea and hypopnea syndrome (OSAHS) in children, is caused by obstruction of upper airway, characterized by repetitive pauses in breathing during sleep despite the effort to breathe, and usually leads to reduction in oxygen saturation. Due to the importance of sufficient oxygen in growth and development, many children patients suffer from abnormal secretion of growth hormone at night, and also their activity and resting of cerebral cortex during sleep. Therefore, they face great risks in keeping normal physical growth, forming mental behavior, building up learning ability and shaping personalities. It is a very important interdisciplinary subject, yet still much remains unclear about the disease. Oral medicine is one of the subjects that show increasing importance in prevention and treatment of OSAHS in children. On one hand, due to the special means of the field, such as cephalometric, it can diagnose and monitor the development of craniofacial structures, especially the upper airway. On the other hand, it can provide treatments which can both improve breath during sleep and consequent dental facial deformities. Most typical treatments include mandibular sagittal growth stimulation, transverse maxillary palatal expansion and maxillary protraction. Oral medicine provides additional treatment apart from traditional adenectomy and tonsilectomy to improve ventilation. It not only directly helps to improve deformities caused by sleep-disordered breathing in OSAHS children with indications, but also helps to avoid many of physical and mental complications, which will in turn benefit their life quality. Also, it may prospectively provide insights in treatment and prevention of OSAHS in adults.
Adult ; Cephalometry ; Child ; Humans ; Mandible ; Maxilla ; Palatal Expansion Technique ; Sleep Apnea Syndromes ; Sleep Apnea, Obstructive