ObjectiveTo explore the clinical efficacy of rehabilitation training combined with electrical acupoint stimulation for hand function of hemiplegic patients.Methods30 hemiplegic patients with hand dysfunction were divided into two groups (observation group and control group, 15 cases in each group), which were given rehabilitation training for hand function. The observation group was given additional acupoint electrical stimulation. Fugl-Meyer motor function score method, classification of hand function, range of motion score were applied to assess the two groups.ResultsThe hand function of the two groups improved(P<0.01), while the observation group was better than the control group (P<0.01).ConclusionRehabilitation training combined with electrical acupoint stimulation can more effectively improve hand function of the hemiplegic patients.

In neuronal system, epigenetic modifications are essential for neuronal development, the fate determination of neural stem cells and neuronal function. The dysfunction of epigenetic regulation is closely related to occurrence and development of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease. Abnormally elevated DNA methylation inhibits the expression of some DNA repair-related genes and affects the progression of Huntington's disease. In the brain of Alzheimer's disease patients, the levels of H3K27ac and H3K9ac histone modifications increased. In addition, the alteration of RNA methylation in animal models of Alzheimer's disease and Parkinson's disease showed discrepancy trends. Therefore, epigenetic modifications may serve as potential therapeutic targets for neurodegenerative diseases. Here, we summarize the recent progress of the roles of epigenetic modifications in neurodegenerative diseases.
Animals ; DNA Methylation ; Epigenesis, Genetic ; Humans ; Neurodegenerative Diseases/genetics* ; Parkinson Disease/genetics* ; Protein Processing, Post-Translational