1.Value of wavelet analysis to ultrasonic diagnosis for liver neoplasms
Qianyun WANG ; Xuejuan WEN ; Wanling LU
China Medical Equipment 2015;(5):24-26
Objective:To investigate the Value of Wavelet Analysis to Ultrasonic Diagnosis for liver neoplasms. Methods: The tissue images of Liver Neoplasms by ultrasonic examination experienced color conversion with Photoshop software, and the corresponding relationship among wavelet coefficient, spacial distribution and local image characteristic after conversion were analyzed, i.e.the row details were arrayed in line sequence,the line details in row sequence and the diagonal details in Zsequence. Results: The frequency spectral data and the image texture information were provided via imaging detection and wavelet analysis of, as well as the quantitative data description of the texture of the foci or the normal tissue. Conclusion:Wavelet analysis provided with a reliable basis for the early clinical diagnosis and treatment for liver neoplasms, by which the focal character and degree can be differentiated or analyzed.
2.Clinical application of wavelet analysis in ultrasonic diagnosis
Xuejuan WEN ; Xiaoying WANG ; Yan ZHANG ; Yingli ZHOU ; Jinzhu WANG
Chinese Medical Equipment Journal 2004;0(09):-
Objecive To observe the characteristic appearance of veins spatial distribution of lump's tissue by using Photoshop so as to improve the ability of ultrasonic diagnosis.Methods The images of lump's tissue gotten from ultrasonic were converted by using Photoshop.Then the corresponding relations between small wave coefficient and local characteristics were analyzed.Result Image determination and wavelet analysis for lump tissue not only provided frequency spectrum and veins analysis for images,but also acquired quantitative data received from focus and normal tissue.Conclusion Wavelet analysis provides reliable basis for distinguishing and analyzing characteristics of focus in clinical lump diagnosis.
3.Association of thyroid-stimulating hormone receptor (TSHR) gene rs2268458 polymorphism with Graves disease and Hashimoto's thyroiditis
Wen TANG ; Heng SHANG ; Yanguo LI ; Xuejuan HE
Chinese Journal of Endemiology 2019;38(3):179-184
Objective To investigate the association of single nucleotide polymorphisms in the rs2268458 locus of thyroid-stimulating hormone receptor (TSHR) gene with Graves disease (GD) and Hashimoto's thyroiditis (HT).Methods Part of the cases diagnosed through the epidemiological investigation project about thyroid diseases of Cangzhou City in 2016 was selected as the case group.The case group was subdivided into GD group and HT group according to the diagnosis.At the same time,healthy people with similar gender and age to the case group were selected as the control group.All subjects were from the Han nationality and were not related to each other.The genotypes and alleles of the TSHR gene rs2268458 (C/T) of all subjects were detected by restriction endonuclease (RFLP).And based on genotyping analysis of patient risk (odds ratio,OR) and 95% confidence interval (95%CI).Results There were 87 cases in GD group [aged (43.17 ± 12.56) years old],including 64 females and 23 males.There were 31 cases in HT group [aged (44.41 ± 16.51) years old],including 26 females and 5 males.In the control group,there were 147 cases [age (40.26 ± 9.31) years old],including 80 females and 67 males.HardyWeinberg equilibrium test was performed on each group.The results showed that P > 0.05,suggesting that the study samples were representative of the population.The results of genetic analysis showed that in females,the C allele frequency of GD patients was significantly higher than that of the control group [x2 =4.632,36.7% (47/128) vs 25.0% (40/160),P < 0.05,OR =1.741,95%CI =1.048-2.891].The frequency distribution of each genotype (CC,CT,TT) at TSHR rs2268458 (T/C) was statistically different (x2 =6.104,P < 0.05),and the frequency of TC ± CC combined genotype was significantly higher in GD patients than in controls (x2 =6.092,P < 0.05,OR =2.333,95% CI =1.184-4.598),however,there was no statistical difference between the HT group and the control group in genotype (CC,CT,TT) frequency distribution and alleles (P > 0.05).In males,there was no statistically significant difference in genotype (CC,CT,TT) frequency distribution and allele between groups (P > 0.05).Conclusion Among women in Cangzhou,the single nucleotide polymorphism of rs2268458 in TSHR gene is associated with the susceptibility to GD,but not to HT,and C genotype increases the risk of GD by dominant inheritance.
4.Determination of Voriconazole in Human Plasma by HPLC
Xuejuan LI ; Sixi LIU ; Zebin CHEN ; Hong WEI ; Weiguo YANG ; Pengqiang WEN
China Pharmacy 2017;28(32):4499-4502
OBJECTIVE:To establish a method for the concentration determination of voriconazole in human plasma.METHODS:Plasma samples were precipitated with acetonitrile.Using ketoconazole as internal standard,HPLC method was adopted.The determination was performed on Dionex U-3000 Dimonsil C18 column with mobile phase consisted of triethylamine-glacial acetic acid-water mixed solution (1 ∶ 1∶98,V/V/V,pH was about 4.0)-acetonitrile (40∶60,V/V) at the flow rate of 1.0 mL/min.The detection wavelength was set at 255 nm.The column temperature was 40 ℃,and sample size was 20 μL.RESULTS:The linear range of voriconazole was 0.2-20.0 μg/mL.The limits of quantification was 0.2 μg/mL,and the minimum detection limit was 0.03 μg/mL.RSDs of inter-day and intra-day were lower than 10%.The method recoveries were 92.06%-106.26% (RSD<5%,n=5),and extraction recoveries were 75.62 %-90.59 % (RSD < 5 %,n=5).The plasma concentration of voriconazole in 10 children ranged 0.22-4.90 μg/mL (n =10).CONCLUSIONS:The method is simple,rapid,specific and can be used for drug monitoring of voriconazole.
5. Prognostic significance of 18F-fluorodeoxyglucose positron emission tomography in patients with diffuse large B cell lymphoma undergoing autologous stem cell transplantation
Zhitao YING ; Lan MI ; Xuejuan WANG ; Yuewei ZHANG ; Zhi YANG ; Yuqin SONG ; Xiaopei WANG ; Wen ZHENG ; Ningjing LIN ; Meifeng TU ; Yan XIE ; Lingyan PING ; Chen ZHANG ; Weiping LIU ; Lijuan DENG ; Jun ZHU
Chinese Journal of Hematology 2018;39(5):382-386
Objective:
To evaluate the prognostic value of 18F-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) in patients with diffuse large B cell lymphoma (DLBCL) undergoing autologous hematopoietic stem cell transplantation (auto-HSCT).
Methods:
Forty-eight patients with DLBCL treated at Peking University Cancer Hospital between November 2010 and December 2014 were assessed. All patients underwent PET/CT scanning prior to or after auto-HSCT. Correlation analysis was done based upon patients characteristics, PET/CT scan results and survival.
Results:
①Among 48 patients, 27 was male, 21 female, median age was 43 (17-59) years old. ② Patients with negative pre-auto-HSCT PET/CT assessment demonstrated significantly better 3-year progression free survival (PFS) (87.1%
6.Efficacy of endoscopic ligation resection and endoscopic submucosal excavation for small gastrointestinal stromal tumors originating from muscularis propria
Chunhong WEN ; Jiang LIU ; Qinglin TANG ; Ming MA ; Huiming LIN ; Lixin DENG ; Zhicong ZENG ; Shuai ZHANG ; Xuejuan HUANG ; Mingqing ZHANG
Chinese Journal of Digestive Endoscopy 2022;39(11):921-924
Clinical data of 43 patients who underwent endoscopic resection for gastrointestinal stromal tumors (GIST) of length ≤1.2 cm at the Digestive Endoscopy Center of the 909th Hospital from January 2016 to December 2018 were retrospectively analyzed. The patients were divided into the endoscopic ligation resection (ELR) group ( n=27) and the endoscopic submucosal excavation (ESE) group ( n=16). The general, perioperative and follow-up data of the two groups were compared. The results showed that there was no significant difference in the general data between the two groups. The operation time was 20.0 (18.0,25.0) min in the ELR group and 27.5 (23.0,37.5) min in the ESE group, showing significant difference ( U=92.5, P=0.001). The en bloc resection rates were 100.0% (27/27) in the ELR group and 81.3% (13/16) in the ESE group, showing significant difference ( P=0.045). The postoperative hospital stays were 3 (2,4) days in the ELR group and 5 (4,6) days in the ESE group, showing significant difference ( U=125.5, P=0.020). There was no significant difference in the intraoperative bleeding rate, intraoperative hemorrhage volume, intraoperative perforation rate, number of hemostatic clips or postoperative complications including hemorrhage, fever and peritonitis between the two groups ( P>0.05). During the follow-up, there was no recurrence or metastasis of GIST in both groups. ELR and ESE can be safe and effective for small GIST ≤1.2 cm in diameter. Compared with the ESE group, the operation time and postoperative hospital stay are shorter with higher en bloc resection rate in the ELR group.
7.Prognostic value of interim and post-therapy 18F-FDG PET-CT in patients with T-cell lymphomas.
Xiaopei WANG ; Huiying HUANG ; Zhitao YING ; Xuejuan WANG ; Yuqin SONG ; Wen ZHENG ; Yan XIE ; Ningjing LIN ; Meifeng TU ; Lingyan PING ; Weiping LIU ; Lijuan DENG ; Chen ZHANG ; Zhi YANG ; Jun ZHU
Chinese Journal of Hematology 2014;35(4):350-352
8.Prognostic value of 18F-FDG PET-CT in Hodgkin lymphoma.
Zhitao YING ; Xuejuan WANG ; Yuqin SONG ; Wen ZHENG ; Xiaopei WANG ; Yan XIE ; Ningjing LIN ; Meifeng TU ; Lingyan PING ; Weiping LIU ; Lijuan DENG ; Chen ZHANG ; Zhi YANG ; Jun ZHU
Chinese Journal of Hematology 2014;35(4):325-327
OBJECTIVETo determine the predictive value of interim and end-of-treatment ¹⁸F-FDG PET-CT after first-line treatment in patients with Hodgkin lymphoma (HL).
METHODSThe clinical data of 50 newly diagnosed HL patients were retrospectively analyzed. Baseline, interim and end-of-treatment PET-CT were performed, and then imaging results were analyzed for the survival of patients via software SPSS 13.0.
RESULTSFifty patients received first-line treatment with ABVD (doxorubicin + bleomycin + vincristine + dacarbazine) or BEACOPP (bleomycin + etoposide + doxorubicin + cyclophosphamide + vincristine + procarbazine+ prednisone) regimen. Interim PET-CT of 35 patients were performed after 2-4 cycles of treatment, 46 patients received PET-CT scans at the end of treatment. After a median follow-up of 29.4 months (12.2-52.4 months), the 3-year progression-free survival (PFS) rates were 100% and 70% for the interim PET-CT negative (n=25) and positive (n=10) patients, respectively (P=0.004). The 3-year PFS rates were 100% and 60% for the post-treatment PET-CT negative (n=36) and positive (n=10) patients, respectively (P<0.01).
CONCLUSIONInterim and end-of-treatment PET-CT were correlated with 3-year PFS rates for HL patients. They may play an important role in predicting the outcome of HL. The relationship with OS can not be determined because of the short follow-up time.
Adolescent ; Adult ; Aged ; Female ; Fluorodeoxyglucose F18 ; Hodgkin Disease ; diagnostic imaging ; Humans ; Male ; Middle Aged ; Positron-Emission Tomography ; Prognosis ; Retrospective Studies ; Tomography, X-Ray Computed ; Treatment Outcome