Objective To analyze the distribution and drug sensitivity of pathogenic bacteria in urinary tract infection,and to provide evidences for rational use of antibiotics in clinic.Methods The data from 3 677 midstream urine specimens for bacterial culture were retrospectively analyzed.VITEK-2Compact was used to identify bacteria and test drag sensitivity.And WHONETS.6 was used to statistically analyze the data.Results Of 649 strains of pathogenic bacteria from urinary tract infection patients,there were 439 strains of gram-negative bacteria,accounted for 67.6％,among which there were 301 (46.4％) strains of Escherichia coli,and 74 (11.4％) strains of Klebsiella pneumoniae;there were 121 strains of gram-positive cocci,accounted for 18.7％,among which there were 97(14.9％) strains of Enterococcus,and 22 (3.4％) strains of Staphylococcus;there were 89 strains of fungi,accounted for 13.7％.According to drug susceptibility,the sensitive rates of Escherichia coli and Klebsiella pneumoniae to imipenem,cefotetan,piporacillin-tazobactam and amikacin were all over 87.0％.The drug sensitivity of Enterococcus to vancomycin and linezolid were both 100.0％.As to drug resistance to other drags,Enterococcus faecium was higher than Enterococcus faecalis.Conclusion Escherichia coli is the primary pathogenic bacteria of urinary tract infection.Every bacteria strain has a high drug resistance.In clinic,hospital should perform urine bacterial culture and drug sensitivity tests timely,and use antibiotics rationally in order to reduce the production and growth of drug-resistant bacteria.

Cancer genomics has led to the discovery of numerous oncogenes and tumor suppressor genes that play critical roles in cancer development and progression.Oncogenes promote cell growth and proliferation,whereas tumor suppressor genes inhibit cell growth and division.The dysregulation of these genes can lead to the development of cancer.Recent studies have focused on non-coding RNAs(ncRNAs),including circular RNA(circRNA),long non-coding RNA(lncRNA),and microRNA(miRNA),as therapeutic targets for cancer.In this article,we discuss the oncogenes and tumor suppressor genes of ncRNAs associated with different types of cancer and their potential as therapeutic targets.Here,we highlight the mechanisms of action of these genes and their clinical applications in cancer treatment.Understanding the molecular mechanisms underlying cancer development and identifying specific therapeutic targets are essential steps towards the development of effective cancer treatments.