Objective To evaluate the effects of Long xuejie capsule combined with Badger Oil on head and neck cancer radiotherapy -induced radiation injuries of skin application value.Methods The received radiation therapy in Ⅱ -Ⅳacute radioactive skin injury in 128 cases were selected.Used the envelope method,they were ran-domly divided into the research group and the control group.Outside the team starts from a radioactive dermatitis with badger oil apply skin irradiation area,with a dragon dragon's blood powder coating outside skin area.Apply 1 -2 times a day,seven days for a course of treatment until wound healing.The control group from a radioactive dermatitis with 0.9% sodium chloride injection,dexamethasone,gentamycin gauze wet moist wound after 30min,1 -2 times a day, 7 days for a course of treatment.Compare the therapeutic effect of the two groups of wet radioactive dermatitis and interruption of radiotherapy and skin lesion healing time.Results The effective rate of the study group was 90.6%, the cure rate was 100%.The effective rate of the control group was 80%,the treatment rate was 62.5%.There was a significant difference between the two groups (χ2 =14.64,11.86,11.48.P <0.01).The vast majority of the study group in a week skin lesions healed,no patients discontinued radiotherapy,the control group 13 cases of termination of radiotherapy,interruption time study group (3.8 ±1.4)d,group interrupt time (8.8 ±1.6)d,lesion healing time of the study group (5.6 ±0.6)d,lesion healing time in the control group (10.6 ±0.8)d.There was a significant differ-ence between the two groups (χ2 =6.68,6.95,11.48,all P <0.05,significant difference).Conclusion Longxuejie capsule combined Badger Oil has significant efficacy in the treatment of radioactive skin injury.It could shorten the healing time,and the method is convenient,economic,security and has certain clinical value.

Objective To compare the values of 3D-SPACE sequence and 2D-TSE sequence for displaying the anatomical details of the sinus tarsi ligament of the ankle.Methods 1.5T Siemens Auanto MRI scanner and 8-channel skull phased array coil were used for the examination of 26 healthy volunteers with 3D-SPACE three-dimensional isotropic sectional scanning as well as 2D-T1WI-TSE transverse and 2D-T2WI-TSE coronal sagittal two-dimensional fast spin echo scan.Two senior MRI radiologists evaluated the display rates of the two sequences for the cervical ligament of sinus tarsi and talus ligament so as to determine the values of the two sequences for displaying the cervical ligament of sinus tarsi.Results 3D-SPACE sequence behaved significantly better than 2D sequence when used to display the sinus tarsi ligament (P＜0.05),and the display rates were statistically different at different positions (P＜0.05).3D-SPACE sequence gained obvious advantages over 2D conventional TSE sequence when used to display the cervical ligament of sinus tarsi and talus ligament,and the highest display rate occurred in case of the cervical ligament of sinus tarsi scanned with 3D-SPACE coronal view and in case of the talus ligament scanned at coronal and sagittal positions.Conclusion 3D-SPACE sequence can display clearly the anatomical details of the sinus tarsi ligament with multiplanar reconstruction,curved planar reformation and etc,and thus is worthy promoting clinically.

Objective To analyze the consistency between 1.5T MRI and arthroscope when used to diagnose anterior cruciate ligament (ACL) injuries.Methods Totally 162 ACL injury patients underwent MRI examination,and the results by arthroscope were used as the diagnosis standard.The curve of receiver operating characteristic (ROC) was applied to evaluating the ACL injuries diagnosis by MRI,and the consistency was analyzed between 1.5T MRI and arthroscope.Results MRI had the sensitivity,specificity and accuracy being 98.69％,81.82％ and 98.77％ respectively when used to diagnose ACL injuries,and there was high consistency between MRI and arthroscope (Kappa=0.909,P＞0.05).Conclusion MRI gains high sensitivity and specificity when used to diagnose ACL injuries as well as high consistency with arthroscope,and thus can be a preferred non-invasive way to diagnose ACL injuries.

Pathophysiology teachers must find the keys of interdisciplinary cross penetration and focus on the link, contacts and differences between pathophysiology and other basic disciplines according to pathophysiolgy text and the law of students' cognitive development. Teachers should guide students to construct the contact figures between pathophysiology knowledge with other subjects of mutual by designing teaching contents and using the teaching method of interdisciplinary cross-penetration-based, clinical problem-oriented and integrations of teaching and research supplemented. Practice of multi-inter disciplinary cross penetration teaching mode in pathophysiology teaching is helpful to improving the teaching quality of pathology physiology and plays a certain role in activeat-ing studetns' study interest, perfecting their knowledge structure and stimulating their innovation awareness.

Objective To explore the possible mechanism of action of telomerase in hepatic precancerous lesions, and the regulatory effect of a Chinese medicine prescription HU Qi Shan ( HQS) and its principal drug mistletoe alkali on the telomerase activity in rat liver tissues.Methods Rat model of hepatic precancerous lesions was established by Solt-Farber two-step protocol.The model rats were randomly divided into 5 groups, including the model group, high-dose HQS [8 g/(kg· d)] group, low-dose HQS [4 g/(kg· d)] group, and mistletoe alkali[8 mg/(kg· d)] group.γ-Glutamy-transpeptidase (γ-GT) was analyzed by immunohistochemistry.AFP was detected by immunofluorescence technique.The telomerase activity was detected using a quantitative telomerase detection kit.The expression of NF-κB P65 was detected by immunohistochemistry.The cytoplasmic protein IκB-αwas detected by western blotting.Results After treated with HQS and mistletoe alkali, the areas ofγ-GT-positive foci and number of AFP-positive cells in the liver tissus were significantly decreased than those of the model group ( P<0.05 for both) , the telomerase activity was decreased, the number of NF-κB P65-positive cells was also decreased ( P <0.05 ) , whereas the intracytoplasmic expression of IκB-αproteins was significantly increased ( P <0.05 ) .Conclusions HQS and mistletoe alkali can suppress the telomerase activity.Its possible mechanism may be through inhibition of the over-expressed apoptosis-related genes such as NF-κB P65 and increase the expression of IκB-αdecreasing the telomerase activity.

The latest epidemiological data suggests that the situation of adult diabetes in China is severe, and metabolic diseases have become significant chronic illnesses that have a serious impact on public health and social development. After more than six years of practice, the National Metabolic Management Center(MMC) has developed distinctive approaches to manage metabolic patients and has achieved a series of positive outcomes, continuously advancing the standardized diagnosis and treatment model. In order to further improve the efficiency, based on the first edition, the second edition guideline was composed by incorporating experience of the past six years in conjunction with the latest international and domestic guidelines.

Background/Aims: Low educational attainment is a well-established risk factor for nonalcoholic fatty liver disease (NAFLD) in developed areas. However, the association between educational attainment and the risk of NAFLD is less clear in China. Methods: A cross-sectional study including over 200,000 Chinese adults across mainland China was conducted. Information on education level and lifestyle factors were obtained through standard questionnaires, while NAFLD and advanced fibrosis were diagnosed using validated formulas. Outcomes included the risk of NAFLD in the general population and high probability of fibrosis among patients with NAFLD. Logistic regression analysis was employed to estimate the risk of NAFLD and fibrosis across education levels. A causal mediation model was used to explore the potential mediators. Results: Comparing with those receiving primary school education, the multi-adjusted odds ratios (95% confidence intervals) for NAFLD were 1.28 (1.16 to 1.41) for men and 0.94 (0.89 to 0.99) for women with college education after accounting for body mass index. When considering waist circumference, the odds ratios (95% CIs) were 0.94 (0.86 to 1.04) for men and 0.88 (0.80 to 0.97) for women, respectively. The proportions mediated by general and central obesity were 51.00% and 68.04% for men, while for women the proportions were 48.58% and 32.58%, respectively. Furthermore, NAFLD patients with lower educational attainment showed an incremental increased risk of advanced fibrosis in both genders. Conclusions In China, a low education level was associated with a higher risk of prevalent NAFLD in women, as well as high probability of fibrosis in both genders.