1.CT Evaluation of Multichannel Cochlear Implantation
Journal of Audiology and Speech Pathology 1998;0(02):-
Objective To investigate the value of CT as preoperative and postoperative imaging technique for cochlear implant candidates.Methods Axial high-resolution temporal bone CT and three-dimensional reconstruction of inner ear were performed in 44 patients with sensorineural hearing loss. Cochlear view radiography was performed routinely in postoperation cases. CT scanning was performed in 3 postoperation cases.Results There were 1 case (2 ears) with Mondini malformation type Ⅰ, 2 case (4 ears)with Mondini malformation type Ⅱ in 32 patients with prespeech deafness. There were 2 case (4 ears) with chronic suppurative otitis meadia, 1 case (2 ears) with inner ear ossification,3 cases (6 ears)with large vestibular aqueduct syndrome,1 case (2 ear)with cochlear sclerosis in 12 patients with postspeech deafness. 1 case with intracochlear electrode knot and otitis meadia was found by CT.Conclusion CT plays an important role in selecting patients, observing implanted electrode and finding postoperative complication.
2.Significance of high-resolution spiral CT and X-ray examination in the evaluation of preoperative selection and postoperative outcome of patients with multichannel cochlear implantation
Chinese Journal of Tissue Engineering Research 2005;9(30):222-223
BACKGROUND:Artificial electronic cochlear (AEC) is a high-tech product used as a therapeutic substitute for pathological cochlear, and the implantative state of AEC can be assessed with the aid of imaging techniques.OBJECTIVE: To investigate the significance of CT and X-ray examination in the evaluation of preoperative selection and postoperative therapeutic result of patients with AEC implantation.DESIGN: Self-control observaton.SETTING:Auditory Rebuilding Ward of Otolaryngology Department, Zhujiang Hospital, Southern Medical University.PARTICIPANTS:Forty-four patients prepared for AEC implantation because of severe sensorineural hearing loss or extremely severer sensorineural hearing loss were recruited from the Otolaryngological Department, Zhujiang Hospital, Southern Medical University from January 1999 to June 2003.Thirty-two patients were with prespeech hearing loss, aged 2.5-12 and 12patients with postspeech hearing loss, aged 10-42.METHODS: Axial high-resolution temporal bone CT and three-dimensional reconstruction of inner ear were performed on 44 patients. They lay in supine position and received bilateral symmetric scanning with view of 9.6 cm. The baseline was set at the level of upper limit of auditory frame, and temporal bone was axially scanned. The scanning parameters were:thickness of 1 mm,spiral distance of 1.0 and interval of 0.5 mm; inserting rebuilding was performed after scanning with thickness of 1mm and interval of 0.1 mm. The improved routine cochlear axial stenves-X-ray image was performed after operation, and three patients underwent spiral CT temporal volume scanning due to suspicious postoperative complications.Postoperative inner ear and the arrangement and depth of implanted AEC.RESULTS: Totally 44 patients were remained in the result analysis perstructure: Of the 32 patients with prespeech deafness, 1 case (2 ears) was diagnosed as type Ⅰ Mondini malformation and 2 cases (4 ears) as type ⅡMondini malformation. Of the 12 patients with postspeech deafness, chronic suppurative otitis meadia was observed in 2 cases (4 ears ) , inner ear ossification in 1case (2 ears ), large vestibular aqueduct syndrome in 3 cases(6the arrangement and depth of implanted AEC :image of X-ray indicated that the electrode was implanted right in cochlea,displaying planar spiral shape and located at the bottom of inner-ear channel. Postoperative CT scanning was performed on 3 cases and revealed that electron was implanted into the bottom surroundings through round window and the electrode got twisted and infected in one cases.three-dimensional reconstruction of inner ear can be adopted before AEC implantation for screening out acute and chronic suppurative and severe ray image can afford clues to know the position and depth of implanted AEC and find out the twist and olithy of electrode, if any CT and cochlea image are supplemented for preoperative case selection and postoperative therapeutic evaluation, helping AEC to exert auditory function to the maximual degree.
3.Application of combination of parenteral nutrition with enteral nutrition in perioperative period of total gastrectomy
Chinese Journal of General Surgery 2001;0(08):-
ObjectiveTo determine the effects of combination of parenteral nutrition(PN) with enteral nutrition (EN) on patients with gastric cancer in perioperative period of total gastrectomy . MethodsIn 52 patients with advanced gastric cancer, 41 had PN support preoperatively and all 52 patients received combination of PN with EN after the total gastrectomy. Results48 of the 52 patients whose intestinal function was recovered within 3 days postoperatively. When using EN, 5 cases felt borborygmus,abdominal pain or mild diarrhea, but these symptoms decreased by slowing down of the infusion speed. The concentration of plasma albumin showed a marked increase on the 10th postoperative day(P
4.Research and application of Medical Ultrasonograph Information Management System
Chinese Medical Equipment Journal 2004;0(07):-
Based on the practical reconstruction of Ultrasonograph Information Management System in Nanjing General Hospital,this paper expounds the hardware architecture,software function and main technology characteristics in detail. The practical application shows that Ultrasonograph Information Management System can realize high-quality display,rapid capture,replay and storage for images,and can provide the functions of quick & accurate research,retrieval and auto statistics,thus effectively improving the work efficiency of ultrasonic diagnoses.
5.Oral microbiota: a promising predictor of human oral and systemic diseases.
Xin XU ; Junzhi HE ; Xuedong ZHOU
West China Journal of Stomatology 2015;33(6):555-560
A human oral microbiota is the ecological community of commensal, symbiotic, and pathogenic microorganisms found in human oral cavity. Oral microbiota exists mostly in the form of a biofilm and maintains a dynamic ecological equilibrium with the host body. However, the disturbance of this ecological balance inevitably causes oral infectious diseases, such as dental caries, apical periodontitis, periodontal diseases, pericoronitis, and craniofacial bone osteomyelitis. Oral microbiota is also correlated with many systemic diseases, including cancer, diabetes mellitus, rheumatoid arthritis, cardiovascular diseases, and preterm birth. Hence, oral microbiota has been considered as a potential biomarker of human diseases. The "Human Microbiome Project" and other metagenomic projects worldwide have advanced our knowledge of the human oral microbiota. The integration of these metadata has been the frontier of oral microbiology to improve clinical translation. By reviewing recent progress on studies involving oral microbiota-related oral and systemic diseases, we aimed to propose the essential role of oral microbiota in the prediction of the onset, progression, and prognosis of oral and systemic diseases. An oral microbiota-based prediction model helps develop a new paradigm of personalized medicine and benefits the human health in the post-metagenomics era.
Biomarkers
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Cardiovascular Diseases
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microbiology
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Dental Caries
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microbiology
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Diabetes Mellitus
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microbiology
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Humans
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Metagenomics
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Microbiota
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Mouth
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microbiology
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Mouth Diseases
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microbiology
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Neoplasms
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microbiology
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Oral Health
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Periodontal Diseases
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microbiology
6.Clinical analysis of different routes of administration of methotrexate combined with hysteroscopy in cesarean scar pregnancy
Xuedong TANG ; Shengfeng XU ; Li LING
Chinese Journal of Biochemical Pharmaceutics 2017;37(3):307-309
Objective To investigate the feasibility of methotrexate incision and different methods of administration combined with hysteroscopic surgery for cesarean scarpregnancy (CSP).Methods Retrospective analysis of 106 patients with CSP in our hospital from January 2001 to December 2015 were.The patients were divided into two groups, group A of 66 cases: methotrexate ( MTX) incision and systemic administration combined with hysteroscopic surgery group B of 40 cases: methotrexate combined with hysteroscopy surgery.The operation time, intraoperative blood loss, preoperative hospital stay, the time of blood HCG decreased to normal, the total amount of MTX and the abnormal rate of liver function were compared between the two groups, and the factors affecting the prognosis of CSP were analyzed.Results The preoperative hospitalization time and abnormal liver function of the two groups were compared, the difference was statistically significant(P<0.05).A group of patients with success and failure, blood HCG before treatment, gestational sac and bladder wall thickness of the myometrium (MT), the difference was statistically significant (P<0.05).The median gestational sac diameter ( GS) of patients with successful treatment was 17.1 mm, and the median number of patients was 6.2 mm, and the difference was statistically significant between the two groups ( GS ) , the difference of GS between the two groups was statistically significant ( P<0.05 ) . Conclusion Methotrexate incision and systemic administration methods combined with hysteroscopy treatment compared with systemic administration combined with hysteroscopy is a safe and effective method and the hospitalization time is short, but the MT >3 mm, before treatment, blood HCG≤20000IU/L, GS≤40 mm CSP more secure.
7.Chemical constituents of Securidaca inappendiculata Ⅱ
Xuedong YANG ; Lizhen XU ; Shilin YANG ;
Chinese Traditional and Herbal Drugs 1994;0(10):-
Object To investigate the chemical constituents of Securidaca inappendiculata Hassk Methods Compounds of 95% alcohol extract from the stem of S inappendiculata were isolated by column chromatography and Medium Pressure Liquid Chromatography, respectively The structures of the compounds were elucidated by chemical and spectral (UV, IR, MS, 1HNMR adn 13 CNMR) analyses Results Six compounds were isolated and identified as: 4, 4′ dimethyl 1, 7 heptanedioic acid (Ⅰ), inositol (Ⅱ), stigmasterol (Ⅲ), vittadinoside (Ⅳ), rhamnose (Ⅴ), sucrose (Ⅵ) Conclusion For the first time, compound Ⅰ was obtained from the plant and other compounds were isolated from Securidaca Mill
8.Precision stomatology: current status and challenges.
Xin XU ; Xin ZHENG ; Liwei ZHENG ; Lei CHENG ; Xuedong ZHOU
West China Journal of Stomatology 2015;33(3):315-321
The completion of human genome project and the progress in medical practice have inevitably lead to the development of precision medicine, which is a medical model that proposes the customization of medical care including medical decisions, practices, and/or medical products with patient's genetic background, environmental factors and life behavior being taken into account. The current work proposed precision stomatology for the first time, and by integrating data reported in recent literature, we described the current practice of precision stomatology in multiple disciplines in modem dentistry. The clinical significance of precision stomatology and its future challenges have also been discussed.
Dentistry
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Humans
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Oral Medicine
9.Progress on space oral medicine research under microgravity environment.
Jing CHEN ; Xingqun CHENG ; Xin XU ; Xuedong ZHOU ; Yuqing LI
West China Journal of Stomatology 2016;34(1):91-95
As an interdisciplinary of stomatology and space medicine, space oral medicine focuses mainly on oral diseases happened under space environment. With the manned space technology stepping into the new era, space oral medicine has been put under the spotlight. This article will review the historical events on this subject, summarize the newly progress especially on craniomaxillofacial bone, tooth-derived stem cell and oral microbiology researches and still put forward future prospect.
Aerospace Medicine
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Biomedical Research
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Humans
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Mouth Diseases
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Oral Medicine
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Stem Cells
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Weightlessness
10.Bacterial diversity in the oral cavity of adolescents with different caries susceptibilities.
Yangyang ZHANG ; Jinzhi HE ; Xin XU ; Xuedong ZHOU
West China Journal of Stomatology 2015;33(6):602-606
OBJECTIVETo analyze the differences between the bacterial diversities in the saliva of caries-free and caries-susceptible adolescents through polymerase chain reaction (PCR)-denaturing gradient gel electrophoresis (DGGE).
METHODSTwenty adolescent subjects aged 12-18 years were recruited and subdivided into two groups: caries-free adolescents (n = 10) and caries-susceptible adolescents (n = 10). Saliva samples were collected. Total DNA was isolated directly from each sample. A portion of the 16S rRNA gene locus was PCR-amplified by using universal primers. Microbial diversity was analyzed through PCR-DGGE.
RESULTSAnalyzing the DGGE profile, we found that the composition of the saliva microbiome exhibited great intra-individual differences; the average band numbers of the caries-free adolescent group and the caries-susceptible adolescent group were 32.5 ± 3.7 and 27.3 ± 3.4, respectively. The differences between the groups were statistically significant (P = 0.008). Shannon-Wiener's indexes of the caries-susceptible adolescent group and the caries-free adolescent group were 2.5 ± 0.2 and 2.6 ± 0.2, respectively, but the differences between the groups were not significant (P = 0.405). Clustering analysis results suggested that most of the samples in the same group clustered together; this observation showed a high community structure similarity.
CONCLUSIONThe microbial diversity and complexity of bacteria in saliva are significantly higher in caries-free adolescents than in caries-susceptible adolescents. During caries development, bacterial diversity in the saliva likely decreases.
Adolescent ; Bacteria ; Child ; DNA, Bacterial ; analysis ; Denaturing Gradient Gel Electrophoresis ; Dental Caries ; microbiology ; Dental Caries Susceptibility ; Humans ; Microbiota ; Mouth ; microbiology ; Polymerase Chain Reaction ; RNA, Ribosomal, 16S ; Saliva ; microbiology