Objective To study effect of Radix Angelica Sinensis (RAS) on Alzhemier's Disease (AD)-like lesions in rats with chronic cerebral hypoperfusion (CCH).Methods rats were randomly divided into sham group,bilateral vascular occlusion (model group),low RAS dose treatment group and high RAS dose treatment group.Cognitive function was assessed by Morris Water Maze and Object Recognition Test.Aβ was detected by ELISA while brain-derived neurotrophic factor (BDNF)、β secretory enzyme 1 (BACE1)、phosphorylated Tau and phosphorylation of Akt/ GSK3β was detected by Western blot.Results There were shorter target quadrant exploration time (TQET),lower priority index (PI) 、phosphorylated Akt/GSK3β expression、BDNF and high-er Aβ1 40 、Aβ1-42 、p-Tau and BACE1 in model group than insham group (P＜0.05,P＜0.01).Low and high RAS dose treatment lengthened TQET,improved PI、phosphorylated Akt/GSK3β expression and BDNF while decreased Aβ1-40 、Aβ1-42 、p-Tau and BACE1 compared with model group.BDNF was higher after high dose RAS treatment than model group (P＜0.01).Conclusion RAS inhibits AD-like lesions in rats with CCH by downregulating the Akt/GSK3β pathway and BACE1 activity,thus improving the cognitive impairment.