1.Study the FOLR1 mRNA expression of 40 esophageal cancerous tissues and relationship between ABO blood group
Jing YU ; Xuanzhi LIU ; Huaiqi YAO ; Suzuan CHEN ; Guanghua GUO
Journal of Chinese Physician 2011;13(8):1045-1048
ObjectiveTo investigate the expressions of folate receptor alpha (FOLR1) in 40 esophageal cancerous tissues and its relevance of ABO blood group.MethodsABO blood groups were analyzed in 40 patients.Immunohistochemistry (IHC) and real-time quantitative reverse transcription PCR detection were used to detect the expression of folate receptor in cancer and adjacent tissues.Results20%of esophageal cancer was suspected positive (+), 50% of cancer adjacent tissue was suspected positive (+), 10% were positive (+), the difference was statistically significant (x2 = 14.48, P <0.01).Real Time RT-PCR analysis showed FOLRI low expression in esophageal cancer and adjacent tissues, compared to normal esophageal mucosa, the differences were statistically significant (F1 =53.247, F2 = 116.500, P <0.01).ABO blood type and FOLRi in esophageal cancer patients were not significant correlated (P =0.647, P >0.05).ConclusionsFOLRI expression was decreased in the esophageal lesions compared with adjacent tissues.Detection of FOLRl expression level in esophageal cancerous tissues and the paired adjacent tissues was helpful for judging the extent of disease and guiding surgery treatment.The FOLRI expression level in esophageal carcinoma tissues had no relationship with ABO blood types.
2.Retroperitoneoscopic ureterolithotomy for upper ureteral calculus: 69 cases.
Hongyi JIANG ; Hongqing ZHAO ; Hongtao WU ; Liang ZHU ; Xiaokun ZHAO ; Xuanzhi ZHANG ; Ren LIU
Journal of Central South University(Medical Sciences) 2011;36(8):791-793
OBJECTIVE:
To review the technical details of retroperitoneoscopic ureterolithotomy and evaluate the clinical effect.
METHODS:
Between June 2004 and December 2008, 69 patients (55 males and 14 females) with upper ureteral calculus received retroperitoneal laparoseopic ureterolithotomy (40 left sides and 29 right sides). The stone size ranged from 1.5 to 3.1 cm [(2.2±0.6) cm].
RESULTS:
All the patients underwent retroperitoneoscopic ureterolithotomy. The operation time was 40-295 (63.1±19.8) min,and the blood loss was 30-150 (57.2±23.0) mL.The hospital stay was 5-8 (6.7±1.3) d. During the followup, there was neither ureteral stricture nor recurrent calculus.
CONCLUSION
Retroperitoneoscopic ureterolithotomy is safe, effective and minimally invasive, which may replace the conventional open surgery.
Adult
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Aged
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Female
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Follow-Up Studies
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Humans
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Laparoscopy
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methods
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Male
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Middle Aged
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Retroperitoneal Space
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Ureter
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surgery
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Ureteral Calculi
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surgery
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Urologic Surgical Procedures
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methods
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Young Adult
3.Study of resting-state functional MRI on immediate effect regulated by acupuncture on acupoints in patients with migraine without aura
Ya'nan ZHANG ; Ni LIU ; Mengmeng REN ; Yueying HONG ; Jianrui ZHANG ; Lei ZHANG ; Xuanzhi LUO ; Huilin LIU ; Jianwei HUO ; Fang HAN
Journal of Practical Radiology 2024;40(1):11-14
Objective To explore the mechanism of immediate effect regulated by acupuncture on acupoints in patients with migraine without aura(MwoA)during the interictal period.Methods A total of 28 MwoA patients were enrolled and resting-state functional magnetic resonance imaging(rs-fMRI)were performed at baseline and after acupuncture for 30 minutes.Paired t test was used to compare the differences of regional homogeneity(ReHo)and voxel-mirrored homotopic connectivity(VMHC)between two groups.Additionally,the correlation between the changes of rs-fMRI indexes and clinical scores was analyzed.Results In MwoA patients after acupuncture for 30 minutes,the mean regional homogeneity(mReHo)was decreased in the right lingual gyrus and right cere-bellum and was increased in the right middle frontal gyrus,while the z transformation voxel-mirrored homotopic connectivity(zVMHC)was significantly decreased in the bilateral cuneus compared with baseline.There was no significant correlation between imaging data and clinical scales.Conclusion Patients with MwoA after acupuncture for 30 minutes show abnormal ReHo and VMHC in multiple brain regions,which suggest that the mechanism of immediate effect may act through regulating pain-related brain regions.
4.Brain Mechanisms of Chemotherapy-Related Cognitive Impairment in Breast Cancer Treated with Acupuncture:Based on Resting-State Functional Magnetic Resonance Imaging
Ziting WU ; Ni LIU ; Yanan ZHANG ; Tingting LIANG ; Xuanzhi LUO ; Qing ZHANG
Journal of Traditional Chinese Medicine 2024;65(5):495-502
ObjectiveTo investigate the mechanism of acupuncture in the treatment of chemotherapy-related cognitive impairment (CRCI) of breast cancer based on resting-state functional magnetic resonance imaging (rs-fMRI). MethodTwenty-five patients with CRCI of breast cancer were included and treated with the acupuncture based on the method of regulating qi and blood, nourishing mind and benefiting intelligence; the selected acupoints included Zusanli (ST 36, bilateral), Xuehai (SP 10, bilateral), Tanzhong (CV 17), Zhongwan (CV 12), Qihai (CV 6), Baihui (GV 20), Fengfu (GV 16, bilateral), Xinshu (BL 15, bilateral), Tongli (HT 5, bilateral), Zhaohai (KI 6, bilateral), Yixi (BL 45, bilateral) twice a week, each time interval of 2
5.A survey on osmotic fragility of erythrocytes in plateau population
Aiping WANG ; Zhuoga LABA ; Wei LI ; Xuanzhi WANG ; Ruolan TAN ; Zhi PU ; ZhiJuan LIU ; Xuzhen QIN
Chinese Journal of Blood Transfusion 2024;37(7):761-765
【Objective】 To study the changes in erythrocyte osmotic fragility(EOF) in patients with hypercythemia, polycythemia and anemia under a high altitude environment. 【Methods】 A total of 174 outpatients, inpatients and people undergoing physical examination in Tibet Autonomous Region People′s Hospital in October 2020 were enrolled and divided into four groups according to hemoglobin levels: the polycythemia group(n=42), the physiologic increase group(n=48), the anemia group(n=29) and the healthy control group(n=55). They were compared with 67 anemia patients and 67 healthy people in the laboratory of Peking Union Medical College Hospital in the same period as the plain control group. The classic EOF test method was used to compare the results of each group′s EOF. The concentrations of NaCl solution for starting hemolysis (STH) and NaCl solution for complete hemolysis (CTH) were included, and the data were statistically analyzed by SPSS software. 【Results】 There was a significant difference in CTH between Zang and Han healthy people (P<0.05). STH in high altitude polycythemia group(0.52) was higher than that in high altitude healthy control group(0.48) (P<0.001). Compared with plain, the median CTH of plateau anemia group(0.36) and plateau health control group(0.36) was significantly higher than that of plain anemia group(0.28) and plain control group(0.28) (P<0.001). Multivariate logistic regression analysis showed that plateau region, female polycythemia and anemia were risk factors for STH elevation. 【Conclusion】 This study finds that the EOF increases in the plateau population and patients with polycythemia, which provides reference for studying red blood cell disorders and blood transfusion strategy in the plateau region.