Objective:To explore the functional mechanism for therapeutic effects of angelica amylose in mice and rats with adjuvant-induced arthritis (AIA) and its effect of abirritation.Methods:Adjuvant arthritis was induced in either mice or rats.The effect of angelica amylose on rats’ arthritis and on mouse writhing response caused by acetic acid were observed.Tripterygium wilfordii was used as the positive drug for control.Results:Angelica amylose had obvious inhibition on mice writhing response and rats’ adjuvant-induced arthritis.Conclusion:Angelica amylose has effects of abirritation and anti-AIA.