Objective To know the TCM discipline development situation through analysis on TCM articles based on Chinese Science Citation Database (CSCD) in recent years. Methods Articles about TCM in CSCD from January 2010 to December 2015 were searched by computers. The CSCD literature analysis system was used to conduct metrological analysis from the aspects of publishing time, source journals, cited information, authors, publishing organizations, research themes, and fund support. Results The number of articles published on CSCD was increasing year by year from January 2010 to December 2015. 85.09% of articles focused on the field of general medicine. There were more than 100 CSCD journals included in TCM professional articles. 17 journals published more than 100 TCM professional articles. WANG Yong-yan academician was the author who published the most articles (121 papers). Academic output H index of six authors was more than 5. 31.52% articles in CSCD were cited. Natural Science Foundation of China (including general and youth projects) funded the highest number of articles (12.2%), reaching 1716 articles. Conclusion Analysis on articles from CSCD can outline the development situation of TCM discipline in China. In recent years, the number of TCM articles is increasing; subject integration is good; high-level teams are forming gradually; TCM discipline is developing fast. However, the citation frequency is low; scholar H index is not high; the overall level remains to be improved.

Objective To set up a method for determination of the trace amounts of aluminium(Ⅲ) in water samples. Methods Second derivative polarogaphy was used. Results In a solution of acetate buffer(HOAc-NH4OH, pH=5.8), Al(Ⅲ)reacted with Berllon Ⅲ to form a complex and a sensitive polarogaphic adsorptive wave appeared at -0.54 V(vs.SCE). By using the 2nd derivative polarogaphy measyrement, the wave height had a linear relationship with the concentration of Al(Ⅲ)in the range of 0.005-0.300 ?g/ml. The limit of detection was 3.0 ng/ml. RSDs were 5.4%-9.1%. Recovery rates were 92.7%-108.0%. Conclusion The present method is sensitive, accurate with high selectivity and can be applied to the determination of the trace amounts of Aluminium(Ⅲ) in water sample with satisfactory results.

Moyamoya disease is a chronic progressive cerebrovascular disease. Its main manifestation is bilateral internal carotid artery progressive stenosis w ith abnormal vascular netw ork formation of the compensatory hyperplasia in brain base. The pathological mechanism of moyamoya disease is not clear. Grow ing evidence has suggested that immune inflammation may play an important role in its occurrence and development process. Abnormal expression of various inflammatory cytokines and immune proteins can be observed in patients w ith moyamoya disease. This article review s the possible mechanism of immune inflammation in moyamoya disease in recent years.

Moyamoya disease is a progressive cerebrovascular occlusive disease, which is characterized by the formation of abnormal vascular network at the brain base. It is an important cause of stroke in children and adults. Now, the etiology of moyamoya disease is not clear. This article reviews its pathogenesis from 3 aspects, including genetic factors, angiogenesis, and immune inflammation.

The incidence of stroke in postmenopausal women increases significantly and is higher than that of men.The overall morbidity and mortality of stroke in women are expected to maintain a sustained upward trend before 2050.The impact of stroke on women is significantly greater than men and mahly manifests in the aspects of older age of onset,more risk factors,lower timely treatment rate,and poor overall prognosis.The influence factors of stroke in women involve many aspects,including sex hormone exposure,chromosomal inheritance,and social status.Researching the pathophysiological characteristics of female stroke and the related factors affecting the diagnosis and treatment contribute to take better effective individualized treatment strategies and decrease the morbidity,mortality,disability rate and recurrence rate in women.This article reviews the epidemiological characteristics,treatment,prognosis and its pathophysiological mechanisms of female stroke.

Thrombolytic therapy is a main treatment method for ischemic stroke.Intravenous recombinant tissue-type plasminogen activator (rtPA) is the only FDA-approved therapy for acute stroke; however,its clinical application has been limited because the narrow therapeutic time window and the presence of the risk of hemorrhagic complication.In order solve these problems,a large number of clinical trials have started to focus on the studies of intra-arterial thrombolysis,mechanical thrombolysis and sonothrombolysis.

The percentage of peripheral blood CD4 + CD28 - T cell in 59 patients with autoimmune hepatitis (AIH) (36 with active disease and 23 stable) and 30 normal individuals was evaluated by twocolor flowcytometry. IL-10 and TNF-α levels were assayed by double-antibody sandwich ELISA. Serum immunoglobulin were also analyzed. Patient with active AIH had significantly higher peripheral blood CD4 + CD28 - T cell and TNF-α levels than normal individuals ( P ＜ 0. 05 ), while in patients with remission they were only slightly higher than normal controls. If remission was induced in patients with active AIH,peripheral blood CD4 + CD28 - T cell percentage would be significantly reduced ( P ＜ 0. 05 ) while IL-10 increased ( P ＜ 0. 05 ). The percentage of peripheral blood CD4 + CD28 - T cell in patients with relapse was significantly higher than newly diagnosed patients and normal controls; Peripheral blood CD4 + CD28 -T cell percentage in patients with abnormal serum immunoglobulin ( IgA, IgG and IgM ) levels was significantly higher than those with normal levels and normal controls. We concluded that abnormal peripheral blood CD4 + CD28- T cells and cytokine in patients with AIH may be related to disease activity and clinical manifestations, which may also play a role in the pathogenesis of AIH.

Objective To study the expression and clinical significance of p16 and p27kip1 in endometrial carcinoma. Methods 65 cases of endometrial carcinoma were examined by immunohistochemical method for p16 and p27kip1. Results The positive rates of p16 and p27kip1 was 47.7 % and 41.5 % respectively. Both the expression of p16 and the expression of p27kip1 were correlated with histologic differentiation. Conclusions p16 and p27kip1 may play important roles in the development of endometrial carcinoma. They were important in predicting the prognosis and directing the treatment of endometrial carcinoma.

Astrocytes are the most abundant neuronal cells in the central nervous system.It plays an important physiological role.In the process of cerebral ischemia,astrocyte activation is one of the major changes in the central nervous system.The activated astrocytes can play a neuroprotective role through the mechanisms such as maintaining ionic balance,regulating energy metabolism,removing excitatory amino acids,against oxidative stress,and secreting neuroprotective substances.However,astrocyte activation after cerebral ischemia also has its disadvantage.This article reviews the neuroprotective and damage roles of astrocyte activation during cerebral ischemia.It also investigates its regulatory mechanisms in order to provide new ideas for the treatment of ischemic stroke.

Objective To investigate the estrogen receptor expression character on neurons and glial cells of rat at different ages. Methods Brain sections from normal and injured rats of different ages were chosen to observe the ER immunohistochemistry reaction in cerebrum. Results To compare with normal young rat group,the neurons in hippocampus dentate gyrus of normal aged rat group expressed much less estrogen receptors.There were many ER-positive glial cells appearing in hippocampus of brain injured was rat group,and the positive strain of young injured was much stronger than that of aged rat group.Conclusion The decrease of ER on neurons in dentate gyrus makes the aged more apt to neurodegeneration.The young rats may better utilize the neuroprotection of estrogen against injuries by increasing the amount of ER on glial cells.