[Objective]To observe the relationship between children pneumonia signs and types.[Method] Make analysis on TCM syndromes of 190 cases of children pneumonia,observe the difference among all syndromes.[Result] The syndrome of phlegm heat blocking lung is featured with fever,heavy cough,much sputum,red tongue,yellow greasy moss,slippery and quick pulse/purple and stagnant finger mark;the syndrome of wind heat with fever,heavy cough,snuffle and runny nose,red tongue,thin and yellow moss,shallow and quick pulse/ purple and shallow finger mark;qi deficiency of lung and spleen with impotent cough,much sputum,pale face,light tongue,white and greasy moss,thin pulse/light red or stagnant finger mark.[Conclusion] The fever,cough sound,sputum spitting or phlegm block degree,nose symptoms,face color,tongue and pulse(finger mark) have much influence on types classification,being the key indexes in differentiation of signs.

Trastuzumab is one of the most important drugs for HER2 overexpressing breast cancer patients. However, even for these patients, the objective response rates to trastuzumab monotherapy are 12%-34%, and the median duration is about 9 months. Many patients progress within 12 months. Study of the mechanisms of resistance to trastuzumab will help us fi nd some new drugs and methods to overcome or delay the resistance.

The antishock properties of Fu-tze "801" , an active fraction isolated from the root of Aconite,were studied on burned rats. The rats were given 65-70% TB'SA second degree scalds. All animals died in a short time postburn. Using this rat model, it was found that the marked spasmodic rhythmic constriction in arterioles occurred and the microierculatory flow state showed pronounced derangements in the me-senteric microcirculation, and platelet aggregate increased in circulating blood.After treatment with Fu-tze "801" , the survival and the mirocirculation were improved in the scalded rats, these findings suggest that Fu-tze "801" affords the antishock action on rats after a major scald burn.

Objective To investigate the role of Ginsenosides Rg1 for non-alcoholic fatty liver disease by β-oxidation.Methods 120 SD rats were randomly divided into control group(CON),model group(HFD),Ginsenosides Rg1low,medium and high dose group (GLD ,GMD and GHD) ,sodium deoxycholate of bear treatment group (PDT ) ,20 rats in each group .After 4 and 8 weeks treatment ,the rats were sacrificed ,Pathology of hepatic tissue was tested by HE staining ,and liver function ,lipid levels ,hepatic ac-yl-CoA synthetase (CoASH1) ,carnitine acyl transferase I(CATI) and acetyl coenzyme A oxidase 1 (ACOX1) mRNA and protein expression were tested .Results After 4 weeks of treatment ,the liver function tested by HE staining only improved in GHD group . After 8 weeks ,there′s a little fat particles aggregation in PDT and GLD groups ,but no infiltration of fat in GMD and GHD groups . After 4 weeks ,AST ,ALT and AKP ,CHOL ,TG and LDL-C levels were significantly lower in PDT ,GLD ,GMD and GHD groups compared with HFD group (P<0 .05) ,which were significant declined 8 weeks later .After 4 weeks ,HDL-C level in four groups was significantly increased ,then reached the normal level 8 weeks later .After 4 weeks ,CoASH1 ,CATI and ACOX1 expressions in hepatic tissue of four groups were significantly increased ,which improved more obviously after eight weeks .Conclusion Ginsen-oside Rg1 can improves nonalcoholic fatty liver phenotype by regulation of β-oxidation .

OBJECTIVE:To provide reference for standardized management of national drug standard in China.METHODS:Special inspections about the implementation of national drug standard were performed in pharmaceutical manufacturers of Deyang area.Based on the results of daily inspections,national drug standard was analyzed and discussed comprehensively.RESULTS:National drug standards were too many and diverse so that they influenced standardized management and implementation,which involved several aspects such as legality and seriousness of the management of drug standard,the conformity of relevant policy with drug standard,the standard of raw material and excipients,standardization of management approach for reference sample.CONCLUSION:Rigorous,complete and accurate national drug standards should be formulated,and relevant laws and regulations should be improved.Pharmaceutical enterprises can be urged to establish standardized drug standard file and to organize production and testing in accordance with national drug standard.

Objective To find new compound from gorgonian.Methods Three ceramides have been isolated from the South China Sea gorgonian Echinogorgia sp.by silica gel column chromatography.Results Their structures were established as(2S,3S,4R)-N-[2-(1,3,4-trihydroxyicosan-2-yl)]-hexadecanamide(1),(2S,3S,4R)-N-[2-(1,3,4-trihydroxyicosan-2-yl)]-heptadecanamide(2),and(2S,3S,4R)-N-[2-(1,3,4-trihydroxyicosan-2-yl]-octadecanamide(3) by spectroscopic methods and chemical conversion.Conclusion It is the first time to report the three chemical compounds from coral Echinogorgia sp.and compound 2 is a new compound.

Objective:To establish a method for the determination of Si migration in penehyclidine hydrochloride injection packed with low borosilicate glass ampoule. Methods: Si migration was determined by graphite furnace-atomic absorption spectrometry. Re-sults:The linear concentration range was 0-85 ng·ml-1(r=0. 995 6). The average recovery was 95. 85% and RSD was 4. 60% (n=9). Conclusion:The method is sensitive, rapid and accurate with good repeatability, which can be used to determine Si migration in penehyclidine hydrochloride injection packed with low borosilicate glass ampoule.

Objective: To investigate the properties of zirconia toughened glass infiltrated nanometer-ceramic composite (Al 2O 3/nZrO 2) . Methods: Zirconia toughened glass infiltrated nanometer-ceramic composite(Al 2O 3/nZrO 2)powder was prepared with combination of chemical co-precipitation method and ball milling. The shape, size, partical distribution, crystal phase and chemical composition were measured and analyzed. Results: (1) The crystal phase composition of the studied nanometer ceramic composite powder was made up with ?-Al 2O 3, t-ZrO 2 and m-ZrO 2 examined by XRD?(2) The density of the powder was 4.12 g/cm 3?(3) The particle distribution of the powder ranged 0.02～3.0 ?m?(4)Observed with SEM, the particle profile of the powder was regular, the ratio of length and width of the particles was about 1.2. Conclusion: The studied nanometer ceramic composite powder owns good homogeneity, stable chemical composition, reasonable powder-size gradation and may be favourable in the improvement of the packing density of ceramics.

AIM: To compare the clinical efficacy and safety of phacoemulsification and small incision non -phacoemulsification cataract surgery, and provide better options for clinical cataract treatment.
METHODS: According to the different operation methods, 98 cases of simple senile cataract patients in our hospital were divided into control group and treatment group, 49 cases in each. The control group received ultrasonic emulsification operation treatment; treatment group were treated by small incision non -phacoemulsification. Visual acuity, astigmatism values, average operation time, and complications were compared between two groups before and after operation.
RESULTS: There was no significant difference in preoperative corneal astigmatism values of two groups at 3mo between two groups (P>0. 05). On other times, vision and corneal astigmatism were obviously better than those before operation (P<0. 05). The average vision, corneal astigmatism values and complications incidence of two group at operation time and different postoperative time had no statistical difference (P>0. 05). When the lens nucleus hardness was at Ⅰ~Ⅲ level, corneal endothelial cell count of two groups had no significant difference ( P>0.05). When the lens nucleus hardness was at Ⅳ ~ Ⅴlevel, there was statistical difference (P<0. 05).
CONCLUSION: Small incision non-phacoemulsification cataract surgery has the similarly efficacy compared with phacoemulsification. It should be based on the actual situation of the hardness of nuclear to select the appropriate surgical treatment.

Objective To observe the therapeutic effect of Jin’s three-needle therapy plus medicated thread moxibustion for shoulder-hand syndrome at phaseⅠ. Methods By simple randomized controlled method, sixty qualified patients were randomized into observation group (N=32) and control group (N=28) . The observation group was given Jin’s three-needle therapy plus medicated thread moxibustion, and the control group was given conventional acupuncture therapy. Treatment was performed once a day for the two groups, 5 continuous times per week, and one course covered 3 weeks. At the end of the treatment, therapeutic effect, simplified Fugl-Meyer scores for upper limb motor ability, and pain visual analog scale ( VAS) scores were compared between the two groups. Results (1) The total effective rate was 93.7% in the observation group and was 82.1% in the control group, the difference being significant ( P<0.05). ( 2) Fugl-Meyer scores were improved in the two groups after treatment (P<0.05 or P<0.01), and the improvement of the observation group was superior to that of the control group ( P<0.05). ( 3) The results of VAS scoring showed that the pain in the upper limb was much relieved in both groups after treatment ( P<0.05 or P<0.01) , and the relief of pain was more obvious in the observation group ( P<0.05). Conclusion Jin’s three-needle therapy plus medicated thread moxibustion exerts certain therapeutic effect for shoulder-hand syndrome at phaseⅠ.