Objective:To discuss the effect of non-invasive mechanical ventilation on acute lung injury with pathologic pregnancy.Methods:A clinical retrospective analysis was carried out to investigate 45 cases of acute lung injury in pathologic pregnancy treated by non-invasive mechanical ventilation in central ICU.Results:Forty-four patients of forty-five were cured (97.8%).Only one patient(2.22%) developed ARDS,and changed to be treated by invasive mechanical ventilation.Conclusion: Pathologic pregnancy is the high risk group of AIS.Using NIPPV early is an effective way to treat,with high success rate of emergency care.The keys of treatment are early diagnosis,early treatment and monitoring of the development of ARDS.

Objective:To investigate the hospital acquired pneumoma in ICU,including its morbidity rate,mortality rate,including factors,and pathogenic distribution and its drug resistance.Methods:A clinical retrospective analysis was carried out to investigate 40 cases of patients acquiring pneumonia in EICU.Results:Twenty-three of 40 cases (57.5%)died.Factors significantly predisposing hospital acquired pneumonia were tracheal intubations or tracheotomy(35%).Pathogenic bacteria Pseudomonas aeruginosa (35%) and Acinetobacter baumannii (20%) were found in most of 40 cases.And the analysis of drug sensitivity showed resistance among all the agents tested in different levels,also the multidrug resistance emerged.Conclusion:Mortality rate of HAP is found high in ICU.The leading causative microorganisms are Gram-negative bacteria,and drug-resistant bacteria.Antibiotics should be appropriately selected.

Objective To investigate the clinical effect of Bella in the treatment of gastric ulcer. Methods According to the different treatment methods will be January 2015-2017 year in March in our hospital 120 cases of patients with gastric ulcer group: control group was treated with amoxicillin + clarithromycin + omeprazole treatment, the observation group used amoxicillin + clarithromycin + ray Bela with before and after treatment; the two groups were observed for clinical symptom score changes, the level of IL-2/IL-6/CRP the incidence of adverse reactions, and the relevant data for comparative analysis. Results Amoxicillin + clarithromycin + ray was Bella (observation group) in the treatment of gastric ulcer is better than omeprazole + amoxicillin + clarithromycin (control group) treatment, clinical symptoms score changes better than the control group, IL-2/IL-6/CRP levels than the control group, the difference was statistically significant (P<0.05); two groups of patients the adverse reaction rate comparison, the difference was not statistically significant. Conclusion The gastric ulcer patients choose amoxicillin + clarithromycin + ray Bella with significant curative effect, can improve the clinical symptoms and IL-2/IL-6/CRP level of patients, and will not increase the incidence of adverse reactions, it is worthy of widely used in the treatment of patients with gastric ulcer.

Objective: To observe the liver function changes and to analyze the risk factors in patients at peri-operative period of cardiopulmonary bypass surgery.
Methods: A total of 108 patients with cardiopulmonary bypass surgery were observed for their liver function at prior and 1, 2, 3, 6 days post-operation, the related risk factors for lever damage were studied by uni- and multivariate regression analysis.
Results: Compared with pre-operative indexes,① at 1, 2, 3 and 6 days post-operation, aspartate aminotransferase (AST), direct bilirubin (DBIL) were increased, serum albumin (ALB), cholinesterase (CHE) were decreased, and at 1, 2, 3 days post-operation, total bilirubin (TBIL) was increased, at 1, 2, 3 days post-operation, alkaline phosphatase (ALP) was decreased, while it increased at 6 days post-operation, allP<0.05;② glutamyl endopeptidase (GGT) was decreased at 1, 2 days post-operation, while it increased at 6 days post-operation,P<0.05;③glutamate pyruvate transaminase (GPT) was increased at 6 days after operation,P<0.05. Univariate regression analysis indicated that cardiothoracic ratio ≥ 0.56 (P<0.05, OR=2.900, 95% CI: 1.206~6.976), cardiopulmonary bypass time (P<0.05, OR=1.042, 95%CI: 1.017~1.068), aortic clamping time (P<0.05, OR=1.041, 95% CI: 1.012~1.070) and lactic acid level at 1 day after operation (P<0.05, OR=1.518, 95% CI: 1.182-1.948) were related to post-operative damage of liver function. Multivariate regression analysis presented that cardiopulmonary bypass time (P<0.05, OR=1.033, 95% CI: 1.007-1.059) and lactic acid level at 1 day after operation (P<0.05, OR=1.340, 95% CI: 1.028-1.745) were the independent risk factors for post-operative damage of liver function.
Conclusion: Multiterm of liver function could be damaged at the early stage after cardiopulmonary bypass surgery; cardiopulmonary bypass time and lactic acid level at 1 day after operation were the independent risk factors for peri-operative damage of liver function in relevant patients.

Objective To explore the effects of patient mutual help-oriented nursing model on social support and hope level in lung cancer patients.Methods Totally 72 lung cancer patients were recruited into the study and divided into the experimental group and the control group with 36 patients in each group.The control group was given routine care,while the experimental group received additional patient mutual help-oriented nursing interventions:physically and psychologically well recovered patients were asked to give emotional communication and interaction to patients newly diagnosed with lung cancer,The Social Support Scale and Herth Hope Index were used for evaluation after the intervention.Results The patients' social support and hope level of the intervention group were significantly better than those of the control group after intervention.Conclusions Patient mutual help-oriented nursing model can improve social support and hope level of lung cancer.

Objective To translate the English version of Career Needs Questionnaires-Short Form (CNQ-SF) into Chinese and to test the reliability and validity of the Chinese version of CNQ-SF in cancer patients.Methods Totally 232 patients with cancer were recruited and were investigated by the Chinese version of CNQ-SF.Results The internal consistency coefficient of the Chinese version of CNQ-SF ranged from 0.792 to 0.937.The content validity index was 0.94.Factor analysis got five factors,which explained 69.8％ of the total variance.Conclusions The Chinese version of CNQ-SF has been proved to be reliable and valid.h can be used as a valid tool for the measurement of information needs of cancer patients.

Laboratory education in basic medicine plays a significant part in medical education.By investigating and analyzing the recent laboratory education in basic medicine,it was found out that the teaching effect of recent laboratory education was basically appropriate.But there was still some deficiency in cultivating problem-solving capability and innovation thinking.

Objective:To investigate the effects of the treatment of early cracked teeth with vital pulp preservation.Methods:63 early cracked teeth with vital pulp in 56 patients were treated by light cured composite resin filling with or without MTA rebasing,and restored by precious metal crown.The patients were followed up for 2 years.Results:After 2 years follow-up,57 teeth were successfully treated and failure was found in 6 teeth,the effective rate was 90.4％.Conclusion:Light cured resin filling directly or with MTA rebasing for early cracked teeth with vital pulp,and restoration by precious metal crown are effective in the treatment of early cracked teeth with vital pulp.

Objective To explore the clinical application value of the serum GP73 detection in the diagnosis of hepatocellular car-cinoma(HCC).Methods The expression level of serum GP73 protein was quantitatively detected by ELISA,including 52 cases of healthy individuals,45 cases of non-hepatic disease,43 cases of viral hepatitis B,20 cases of liver cirrhosis and 30 cases of HCC;The levels of GP73 were compared among the 5 groups.Serum a-fetoprotein(AFP)level in the HCC patients was detected by electro-chemilumnescence(ECL)method.The area of receiver operating curve(ROC),sensitivity and specificity of GP73 and AFP for diag-nosing HCC were calculated.Results The serum level of GP73 was (58.57 ± 35.64)ng/mL in the non-hepatic disease group, (70.36±49.88)ng/mL in the viral hepatitis B group,(114.47±51.27)ng/mL in the liver cirrhosis group and (251.37±95.6)ng/mL in the HCC group,which in the patients was significantly higher than(34.03±15.20)ng/mL in the healthy control group,the differences had statistical significance(P <0.05);The serum GP73 level in the HCC group was significantly higher than that in the other groups with statistical difference(P <0.01);The positive detection rate of serum GP73 in the HCC group was 76.7%,which was significantly higher than 3.12% in the non-HCC group,the difference had statistical significance(χ2 =108,P <0.05);The sen-sitivity and specificity of GP73 for diagnosing HCC were 75.1% and 94.9% respectively,which were significantly higher than those of the AFP(52.3% and 86.6%).Conclusion GP73 could be to become a better serum marker for diagnosing HCC.

Objective To investigate the effect of tea polyphenols and sulforaphane on the expression of protein kinase A anchoring protein 95 and cyclin E2 in lung cancer tissue.Methods 56 cases confirmed by pathology and operation therapy for lung cancer patients,were randomly divided into combined treatment group and control group,each had 28 cases.The content of protein kinase A anchoring protein 95 and cell cycle protein E2 in all patients were determined with ELISA.The expression of protein kinase A anchoring protein 95,cyclin E2 and statistics of microvessel density(MVD) were detected by immunohistochemical SP method.The protein levels of protein kinase A anchoring protein 95 and cell cycle protein E2 protein were detected by Western Blot. Results The contents of protein kinase A anchoring protein 95 and cyclin E2 in control group were higher than that in combination group,the differences were statistically significant(P<0.01 ).Immunohistochemical SP results showed that protein kinase A anchoring protein 95 and cyclin E2 expression all had positive expression,and the MVD in control group was higher than combination group(P<0.01);Western Blot results showed that the expressions of protein kinase A anchoring protein 95 and cyclin E2 protein in control group were higher than combination group(P<0.01).Conclusion Protein kinase A anchoring protein 95 and cyclin E2 expressions are increased in both groups in lung cancer tissues,and they are positively correlated,negatively correlated with drug treatment,which can be used as the indexes of lung cancer evaluation.