1.Role of TNF-αin retinal neural degeneration diseases
Fengao XIE ; Qinglei SONG ; Xizhou ZHANG
Basic & Clinical Medicine 2015;(2):262-265
Retinal neural degeneration diseases is one of the main causes of vision loss , TNF-αas an inflammatory cytokine with pleiotropic biological activity , after binding to its receptor by a variety of signaling pathways , may have play critical role in pathogenesis of retinal neural degeneration diseases including glaucoma , ischemic retinop-athy, age-related macular degeneration and retinitis pigmentosa .
2.EFFECT OF OXYGEN ENRICHMENT OF ROOM AIR ON THE HEMORHEOLOGY OF SOLDIERS AFTER EXHAUSTION-EXERCISE AT 3700m ALTITUDE
Xizhou ZHANG ; Jianhua CUI ; Yinh WANG
Medical Journal of Chinese People's Liberation Army 1982;0(03):-
To study the effect of oxygen enrichment of room air on the change of hemorheology of soldiers after high altitude hypoxia and exhaustion exercise at 3700 altitude, the oxygen concentration was increased to 24 0%~25 0% in the rooms at 3700m altitude, the change of hemorheology in 10 soldiers after they had 12h rest and sleep in the oxygen enrichment room was examined in no oxygen enrichment resting state and in oxygen enrichment state as well as after exhaustion exercise in no oxygen enrichment room and in oxygen enrichment room.Hematocrit (HCT), blood viscosity (?b), reduction viscosity (?r) and viscometric aggregation index (VAI) were higher after exhaustion exercise in no oxygen enrichment room as compared with those in no oxygen enrichment resting state, the difference was very significant or signifant ( P 0 05),?b, Plasma viscosity (?p), ?r were decreased after exhaustion exercise in no oxygen enrichment room ( P
3.THE CURATIVE EFFECTS OF L-ARGININE ON HIGH ALTITUDE PULMONARY EDEMA
Xizhou ZHANG ; Yong MA ; We WANG
Medical Journal of Chinese People's Liberation Army 1983;0(05):-
In order to study the curative effects of L arginine (L Arg) on high altitude pulmonary edema (HAPE),we had treated 10 patients with HAPE by intravenous L Arg at 3700m, and the result was compared with 11 patients who inhaled low concentration nitric oxide (NO) and 24 subjects with routine treatment.The findings were as follows:compared with the routine group, inhaling NO or intravenous L Arg could hasten the disappearance of moist rales and X ray shadow, and shorten the illness time( P 0.05). It suggested that intravenous L Arg is a handy way to treat HAPE, and there is no toxicity. It is worthy of further trial.
4.Prevalence and Resistant Characteristics of Clinical Isolates of Enterobacter cloacae
Guang ZHOU ; Dingxia SHEN ; Yanping LUO ; Xizhou GUAN
Chinese Journal of Nosocomiology 2006;0(03):-
OBJECTIVE To study the prevalance and resistance characteristics of clinical isolates of Enterobacter cloacae.METHODS Clinical isolates of E.cloacae were studied by K-B methods,and the data of MIC were(analyzed ) by WHONET 5.3 software.RESULTS Totally 416 clinical isolates of E.cloacae isolated from 2000 to 2004 were studied and they were mainly isolated from department of respiration,surgical ICU and department of(neurology) and their rate was 25.2%,9.6%,and 8.6%,respectively.The E.cloacae strain was(resistant) to ciprofloxacin,amikacin and most of penicillins,cephalosporins and ?-lactams combined with the(?-lactamase) inhibitors.It was susceptible to cefepime,imipenem and etrapenem.CONCLUSIONS The E.cloacae is resistant to many commonly used antibiotics in clinics and it is important to control antibiotic(resistance) by using antibiotics reasonably.
5.The Clinical Observation on Naloxone and Trimetazidine in the Treatment of 40 Cases of Severe Viral Myocarditis.
Yong DONG ; Xizhou ZHANG ; Ping TIAN ; Wen ZHOU
Journal of Medical Research 2006;0(03):-
Objective To estimate the clinical efficacy of naloxone and trimetazidine in the treatment of severe viral myocarditis.Methods40 patients with severe viral myocarditis were randomly divided into two groups: control group(20cases) and treatment group(20 cases).All patients in control group and treatment group received conventional therapy.In adition,the patients in treatment group received naloxone and trimetazidine treatment.After 14 days,the changes of clinical symptoms were observed.In addition,serum creatinine kinase(CK)-MB and cardiac troponin I(cTnI) levels were measured.ResultsAlthough the symptoms,CK-MB and cTnI were significantly improved in two groups,but significant difference was still found between control group and treatment group(P
6.Exploitation and Application of Medical Service Management Information System for Field Medical Point
Qicai HE ; Xiaoyun LI ; Yongsheng WU ; Xizhou WANG ; Hao HU
Chinese Medical Equipment Journal 2004;0(08):-
Objective To strengthen the capability of emergent supply in field medical point.Methods The common application program was designed by using PowerBuilder.The database program was Oracle.Results The assistant conduction and management of information were realized including the information of staff,war materials,equipment,wounded soldiers in the field medicine.Conclusion Information management system in field hospital can rapidly and accurately provide all kinds of information for users.It can be extensively applied in all levels of field hospitals.
7.Analysis of the Costs of Various Drugs Consumed in 36 Hospitals of Guangzhou in the Years 1997~ 2000
Qinghuan WU ; Xizhou XIAO ; Lingyan MA ; Caiyun CHEN
China Pharmacy 2001;12(5):285-286
OBJECTIVE: To analyze the trend of costs of various drugs consumed in hospitals of Guangzhou METHODS: The data were derived from the Hospital Purchasing of Drug Information System in Guangzhou from 1997 to 2000 The expense of each drug was calculated at the price of that year RESULTS: The annual increasing rates of drug expenses in 1998, 1999 and 2000 were 17 01% , 24 49% , 23 11% respectively CONCLUSION: It is a matter of great urgency to rationally use drugs, to eliminate the waste of resources and to lighten the patients'burden
8.Analysis of the Costs of Various Drugs Consumed in 36 Hospitals of Guangzhou in the Years 1997~2000
Qinghuan WU ; Xizhou XIAO ; Lingyan MA ; Caiyun CHEN
China Pharmacy 1991;0(05):-
OBJECTIVE:To analyze the trend of costs of various drugs consumed in hospitals of Guangzhou METHODS:The data were derived from the Hospital Purchasing of Drug Information System in Guangzhou from 1997 to 2000 The expense of each drug was calculated at the price of that year RESULTS:The annual increasing rates of drug expenses in 1998,1999 and 2000 were 17 01%,24 49%,23 11% respectively CONCLUSION:It is a matter of great urgency to rationally use drugs,to eliminate the waste of resources and to lighten the patients'burden
9.Endoscopic variceal ligation versus endoscopic variceal sclerotherapy in treatment of esophageal variceal bleeding:a meta-analysis
Jiangwei ZHOU ; Yesu LIN ; Xizhou LIN ; Yingcong YU ; Liang ZHENG
China Journal of Endoscopy 2017;23(1):39-46
Objective To make a systematical review of the efficacy and safety of endoscopic variceal ligation versus endoscopic variceal sclerotherapy for treatment of esophageal variceal bleeding. Methods We electronically searched databases including PubMed, Web of Science, The Cochrane Library (Issue 2, 2016), CNKI, WanFang Data and from Jan., 1980, to Mar., 2015, collected randomized controlled trials (RCTs) about EVL versus EVS for the patients of esophageal variceal bleeding. Then, meta-analysis was performed using RevMan 5.3 software. Results A total of 24 studies including 2020 patients were included. The results of meta-analysis showed that, there were no signiifcant differences in the variceal eradication rate (RR=1.04, 95%CI 0.99 to 1.09, P=0.090) between the EVL group and the EVS group; Compared with the EVS group, the EVL group could significantly reduce the rate of variceal rebleeding (RR=0.69, 95%CI 0.59 to 0.81, P=0.000), the rate of mortality (RR=0.76, 95%CI 0.63 to 0.90, P=0.002) and the rate of complication (RR=0.41, 95%CI 0.26 to 0.63, P=0.000), but the rate of variceal recurrent rate of EVS group was lower than that of the EVL group (RR=1.67, 95%CI 1.40 to 2.01,P=0.000). Conclusion Current evidence shows that, the variceal eradication rate between EVL and EVS is similar, but the EVL has less incidence of variceal rebleeding and mortality and complication.
10.SALL4 expression in children with acute leukemia and its clinical significance
Jianghua LIU ; Jie YU ; Ni ZHANG ; Yanzhen WANG ; Shaoyan LIANG ; Xizhou AN
Chinese Journal of Clinical Oncology 2014;(20):1288-1292
Objective:To investigate the expression of sal-like 4 (SALL4) gene in children with acute leukemia and analyze its clinical significance. Methods:Real-time PCR and immunohistochemistry were used to detect SALL4 mRNA and SALL4 protein ex-pressions in 50 patients initially diagnosed with acute leukemia and in 15 patients with immune thrombocytopenic purpura (ITP), which served as controls. Changes were detected in SALL4 mRNA expression from preliminary diagnosis and after complete remission of 5 acute leukemia patients. The relationship between SALL4 mRNA expression and clinical indicators was analyzed. Results: SALL4 mRNA expression is higher in initially diagnosed B-ALL [13.89 (1.00-63.15)] and AML [11.12 (2.31-56.59)] than in ITP controls [1.00 (0.29-1.71)] (P<0.01). SALL4 mRNA expression in initially diagnosed T-ALL [1.48 (0.87-4.81)] and in controls showed no significant difference (P>0.05). SALL4 protein expression is in agreement with SALL4 mRNA expression. SALL4 mRNA expression significant-ly decreased in complete remission stage [0.98 (0.22-1.09)] than in acute phase [28.64 (11.20-87.46)] in acute-leukemia patients (P<0.01). High SALL4 mRNA expression level is positively correlated with high white blood cell count, high risk classification, and high minimal-residual disease at the end of induction chemotherapy (r=0.424, r=0.40, and r=0.393, respectively;P<0.05), but not with age, gender, hepatomegaly, splenomegaly, and lymphadenectasis (P>0.05). Conclusion:SALL4 was found to play an important role in pro-moting childhood B-ALL and AML, which promises a new target for monitoring the therapeutic effects and evaluating the prognosis of childhood B-ALL and AML.