1.Effects of Wujibaifeng Pills on lipid metabolic changes in ovariectomized rat
Xinguo WANG ; Xizhen GE ; Wei MA ; Huazhou XU ; Gang CAO
Chinese Traditional Patent Medicine 1992;0(05):-
Objective: To investigate the antiatherosclerotic effect of Wujibaifeng Pills and its mechanism. Methods: Rat dyslipidema was induced by ovariectomy (OVX), the levels of serum lipids, superoxide dismutase (SOD) activities and malondialdehyde (MDA) were detected after 12 weeks with the treatment of wujibafeng pills. Results: Wujibaifeng Pills lowered serum oxidized-low density lipoprotein cholesterol (OX-LDL,P
2.Pathway design and key enzyme analysis of diosgenin biosynthesis.
Zhongyi SUN ; Peng ZHAO ; Xizhen GE ; Pingfang TIAN
Chinese Journal of Biotechnology 2021;37(4):1178-1188
As a naturally occurring steroid sapogenin, diosgenin acts as the precursor of hundreds of steroid medicines, and thereby has important medicinal value. Currently, industrial production of diosgenin relies primarily on chemical extraction from plant materials. Clearly, this strategy shows drawbacks of excessive reliance on plant materials and farmland as well as environment pollution. Due to development of metabolic engineering and synthetic biology, bio-production of diosgenin has garnered plenty of attention. Although the biosynthetic pathways of diosgenin have not been completely identified, in this review, we outline the identified biosynthetic pathways and key enzymes. In particular, we suggest heterologous biosynthesis of diosgenin in Saccharomyces cerevisiae. Overall, this review aims to provide valuable insights for future complete biosynthesis of diosgenin.
Biosynthetic Pathways/genetics*
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Diosgenin
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Metabolic Engineering