Objective To investigate the curative effect and care measures using subhypothermia treatment in patients with severe brain injury.Methods 70 cases of severe brain injury were randomly divided into treatment group(n=35) and control group (n=35),the treatment with subhypothermia and correlation care,control group treated with conventional treatment care.Compared rate of cure,mortality and complications in two groups.Results In treatment group cured 30 cases ( 85.7% ),5 patients died (14.3% ),the control group cured 23 cases (65.7%),death 12 cases(34.3%).Two groups had significant difference (x2 = 4.15,x2 = 3.99,P ＜ 0.05 ).The GOS score (3.23 ±2.15) points in treatment group were lower than the control group(5.03 ±0.96) points after treatment(t =3.52,P ＜0.05).The incidence of complications in the treatment group was 17.0% (6/35) lower than the control group,37.1% (13/35 ) (x2= 3.95,P＜0.05).Conclusion Subhypothermia care may reduce complications in patients with severe brain injury.