OBJECTIVE:To evaluate the cost-effectiveness of 3 kinds of traditional Chinese medicinal injections in the treatment of angina pectoris caused by coronary heart disease(CHD).METHODS:223 CHD patients with angina pectoris were divided into 3 groups:group A(Xuesaitong injection),group B(Breviscapine for injection) and group C(Shuxuening injection). The curative effects were observed and the cost-effectiveness analyses of the 3 groups were conducted as well.RESULTS:The costs for the 3 groups were 1 345.50 yuan,1 768.125 yuan,1 770.00 yuan,respectively; the total effective rates were 83.75%,82.09% and 85.53%,respectively; the cost-effectiveness ratios were 16.07,21.54 and 20.69,respectively;the incremental cost-effectiveness ratios of group B and C were 254.60 and 238.48,respectively as against group A. CONCLUSION:Xuesaitong injection(group A) is the preferred therapy for angina pectoris caused by CHD.

Objective To establish the determination method of syringin and syringaresinol in Ciwujia Injection with RP-HPLC. Methods C18 ODS was used as a stationary phase. The mobile phase consists of water and acetonitrile. The gradient condition was 0→20 min, A:90%→50%. The flow rate was 1.0 mL/min. The detective wavelength was set at 220 nm. Results The linear range of syringin was 0.03～0.16 ?g (r =0.999 7, n=5) and the linear range of Syringaresinol was 0.02～0.13 ?g (r =0.999 3, n=5). The average recovery of syringin was 99.34% and RSD=0.58%. The average recovery of Syringaresinol was 99.22% and RSD=0.71%. Conclusions The method was simple, convenient and accurate, and can be used for content determination of syringin and syringaresinol in Giwujia injection.

OBJECTIVE:To evaluate the cost-effectiveness of3kinds of traditional Chinese medicinal injectable prepa?rations in the treatment of children's fever caused by exogenous pathogens METHODS:44cases were assigned to receive Qin_ gkailing injection(Group A),Shuanghuanglian for injection(Group B)and heartleaf houttuynia herb injection(Group C),re?spectively.The curative effects of the3groups were observed and the cost-effectiveness analysis were conducted as well.RESULTS:The costs for the3groups were28.68yuan,45.00yuan and59.40yuan,respectively;the total effective rates were80.00%,86.67%and85.71%,respectively;the cost-effectiveness ratios of the3were35.85,51.92and69.30,re?spectively;the incremental cost-effectiveness ratios of Group B and C were244.68and538.00,respectively as compared with Group A.CONCLUSION:Qingkailing injection(Group A)is the preferred option in the treatment of children's fever caused by exogenous pathogens.

AIM: To investigate the characterization of absorption of hematoporphyrin monomerthyl ether (HMME), a domestic new generation photosensitizer product, by activated T cells from human peripheral blood. METHODS: Evaluation was performed by flow cytometry on the effects of incubating concentration and time of HMME on absorption by activated T cells. Lymphocytes were separated from human peripheral blood by density gradient centrifugation with Ficoll and T cells were activated with polyclonal stimulators PHA and PDB+Ion. To analyze the effects of HMME incubating doses on the absorption of activated T cells, the cultural lymphocytes were incubated with a serial doses of HMME for 1 h and HMME absorption were measured by FACS after immuno-staining with anti-CD3 antibody. To test the impact of HMME incubating time on the absorption of activated T cells, the cultural lymphocytes were incubated with HMME for various times and HMME absorption were measured by FACS after immuno-staining with anti-CD3 antibody. RESULTS: The HMME absorption-dose curve and absorption-time curve were shifted to right and up in the activated T cells as compared to resting T cells. HMME absorptions of activated T cells were statistic significantly larger than that of resting T cells in the doses between 5 mg/L to 20 mg/L. HMME absorptions of either activated T cells or resting T cells underwent a gradual increase with the incubation-time in HMME at concentration of 10 mg/L. HMME absorptions of activated T cells were statistic significantly larger than that of resting T cells in the incubation-time between 15 to 60 min. CONCLUSION: The differences of HMME absorption between activated T cells and resting T cells depend on the incubation times and doses of HMME. HMME absorption of activated T cells are significantly larger than that of resting T cells in certain incubation-times and doses. These results suggest that incubation time and dose associated with HMME-PDT therapeutic windows will be created for selective deletion of activated T cells.

Objective:To discuss the effect of pharmacist intervention on the use of antimicrobial agents in the clinical pathway of community-acquired pneumonia ( CAP) in our hospital to standardize the rational medication and promote the rational use of antimicro-bial agents. Methods:Totally 100 bacterial CAP patients in 2013 ( before the intervention) and 2014 ( after the intervention) in the pneumology department were studied. The antibacterial drug cost, total hospitalization cost, use intensity of antimicrobial drugs, hospi-talization time, therapeutic effects and so on in the two groups were observed during the treatment. Results: There were significant differences between the two groups in antibacterial drug cost, total hospitalization cost, use intensity of antimicrobial drugs, hospitaliza-tion time and so on, whereas there was no significant difference in the curative effect. Conclusion:After the pharmacist intervention, the application of antibiotics is more rational, the antibiotics use density and per capita cost are reduced, the hospitalization day is shortened and the value of pharmacists is also improved.

Objective To explore the effect of self-efficacy theory on nursing of patients with lung cancer.Methods Totals of 80 patients with lung cancer were randomly divided into study group and control group,control group received routine treatment and nursing,while study group received self-efficacy intervention measures.Between the two groups,patients' self-efficacy and quality of life (WHOQOL-100) score were compared.Results The score of self-efficacy in study group and control group respectively was (37.05 ± 4.23) and (31.12 ±5.21).And the quality of life (WHOQOL-100) score in study group and control group was (77.14 ±4.25) and (62.03 ± 4.52),respectively.Patients' self-efficacy and quality of life scores of two groups were significantly increased (t =5.607,15.403,respectively; P ＜ 0.01).Conclusions Self-efficacy theory has a guiding meaning for pain care of cancer patients,which can improve the quality of life of patients.

Objective To explore structured psychological intervention in improving lung cancer patients’ preoperative self-efficacy.Methods Totals of 60 patients with lung cancer were randomly divided into the study group and the control group .The control group was given conventional nursing care .The study group was given structured psychological nursing intervention , including psychological support , health education , stress treatment and coping technique .Before and after 5 days of the intervention , patients ’ self-efficacy was compared.Results The General Self Efficacy Scale ( GSES) scores before and 5 days after intervention were (26.25 ±4.05) and (36.23 ±4.54) in the study group, and (26.18 ±6.21) and (30.05 ±5.05) in the control group .And the structured psychological intervention can significantly improve the preoperative self -efficacy level of patients with lung cancer (t=4.98,P<0.05).Conclusions The structured psychological intervention can enhance preoperative patients ’ self-efficacy, and can effectively help patients cope with disease and surgery.

Objective To compare the clinical efficacy of ibuprofen arginate,a new nonsteroidal antiinflammatory drug,with that of ibuprofen,in patients with rheumatoid arthritis or knee osteoarthritis and to evaluate the safety and tolerability of ibuprofen argihate.Methods This is a muhicenter,random,open,active comparator-controlled,parallel clinical trail in which 171 patients with rheumatoid arthritis or knee osteoarthritis were enrolled.Patients were randomized to 2 groups:400 mg of ibuprofen arginate three times daily and 400 mg of ibuprofen three times daily respectively.Clinical efficacy and safety were evaluated after 4-week treatment.Results Ibuprofen arginate,at dosages of 400 mg three times daily,had shown significant efficacy in relieving pain,tenderness and swelling of joints and there was no significant difference when compared to that of ibuprofen.There was no difference in clinical adverse effects between the two groups and no serious adverse effects were repofled.But ibuprofen arginate could initiate effectiveness more rapidly than ibuprofen in both rheumatoid arthritisand osteoarthritis patients.Conclusion Ibuprofen arginate has the same clinical efficacy and safety profiles as itmprofen in treating rheumatoid arthritis and osteoarthritis.However,its onset is more rapid than ibuprofen.