Objective To investigate the pregnancy outcomes of in vitro fertilization (IVF) and embryo transfer (ET) in infertile women with polycystic ovarian syndrome (PCOS).Methods From August 2005 to June 2011,200 IVF-ET cycles performed in women with polycystic ovarian syndrome in Shengjing Hospital and Shenyang 204 Hospital were enrolled in this retrospective study,matched with 400 IVF-ET cycles in infertile women with fallopian tube factors as control group.The incidence of abortion,gestational diabetes mellitus (GDM),hypertensive disorders in pregnancy,preterm birth,small for gestational age infant(SGA),large for gestational age infant (LGA),neonatal asphyxia,neonatal death and deformity was compared between two groups.Results The incidence of spontaneous abortion was 26.0％ (52/200) in PCOS group,which was significantly higher than 10.2％ (41/400) in control group (P ＜ 0.05).The incidence of GDM,hypertensive disorders in pregnancy,preterm birth,cesarean section in PCOS group was 23.6％ (35/148),16.2％ (24/148),17.6％ (26/148),83.1％ (123/148),which were significantly higher than 4.2％ (15/359),6.1％ (22/359),7.8％ (28/359),73.8％ (265/359) in control group (P ＜0.05).The incidence of SGA,LGA,neonatal asphyxia,neonatal death and deformity did not show remarkable difference between two groups,which were 2.7％ (4/148),4.7％ (7/148),5.4％ (8/148),0 in PCOS group and 1.4％ (5/359),2.2％ (8/359),2.8％ (10/359),0 in control group (P ＞0.05).Conclusion IVF-ET is an effective treatment for infertile women with PCOS,however,the incidence of spontaneous aborcion,GDM,hypertensive disorders in pregnancy,preterm birth,cesarean section in PCOS patients was increased.

To review the scientific evidence of system management for lung cancer patients with cancer- related fatigue by the method of literature review and evaluate researchers on authenticity, importance and applicability, in order to improve the nursing quality and the quality of life of them. Interventions of lung cancer patients with cancer- related fatigue mainly includes: non- drug intervention, drug intervention and self- management. The use of intervention measures should be combined with the situation of the patients. however, many of the effectiveness of the intervention measures not sure, need large sample randomized controlled trial verifies the results .

Objective To systematically evaluate the effectiveness of intermittent nasogastric feeding on enteral nutrition of critical patients. Methods The relevant randomized controlled trials were searched in the Cochrane Library, PubMed, EMbase, Web of Science, JBI Library and the databases of China National Knowledge Infrastructure (CNKI), China Scientific Journal Database by VIP (VIP), Wanfang Database. The studies were selected according to the inclusion and exclusion criteria by two reviewers. Meta- analysis was conducted by using RevMan 5.2. Results Nine RCTs were included involving 558 patients. The results of meta- analysis showed that intermittent nasogastric feeding was greater than continuous pump feeding in the incidence of constipation, OR=0.32, 95%CI 0.14~0.71, P<0.05, the difference was significant. However, they were alike in the incidences of diarrhea, aspiration pneumonia, gastric residuals, vomiting, abdominal distension and effects of nutrition, there was no statistical difference (P>0.05). Conclusions Intermittent nasogastric feeding and continuous pump feeding did not affect the incidence of diarrhea, aspiration pneumonia, gastric residuals, vomiting, abdominal distension and the effects of nutrition. However, the incidence of constipation was significantly less in patients receiving intermittent nasogastric feeding.

Objective: To denvolop HPLC an method for the determination of the content of three saponins in Zhixiao suppositories. Methods: Analysis carriedout was performed on a Kromasil C18 column (4.6 mm×250 mm., 5μm)at 23℃. The mobile phases were methanol and 0.2% phosphoricacid solution in a gradient elution. The flow rate was set at 1.0 mL·min-1 and the ultraviolet detector was operated at 203 nm. Results: The linear ranges of notoginsenoside R1, ginsenoside Rg1 and ginsenoside Rb1 were 0.368～2.76μg,0.676～5.07 μg and 0.812～6.09μg,respectively. The average recoveries of the three saponins were 98.53%, 99.20% and 99.35%, respectively. The RSD (n=5) were 2.11%, 1.88% and 2.38%, respectively. Conclusion: The separation is a good and the results are accurate and reproducible. It can be used for the quality control of Zhixiao suppositories.

The purpose of this study was to clarify the strains of E .granulosus from sheep of Xiwuqi and people of Xil-inhot in Inner Mongolia region and its genotypes .CO1 and ND1 of mitochondria gene were cloned and sequenced ,and then they were analyzed by MegAlign of DNAStar5 .0 .Results showed that the length of CO1 and ND1 gene of E .granulosus ,which were from sheep of Xiwuqi or people of Xilinhot ,were 936 bp and 895 bp ,respectively .The homology of CO1 gene sequences of E .granulosus strains from Xiwuqi and Xinjiang was 99 .3% ,while the homology of the corresponding gene sequences of E .granulosus from man of Xilinhot City and Xinjiang were 98 .6% .ND1 gene of E .granulosus of sheep from Xiwuqi and hu-man from Xilinhot were identical to ND1 gene of G1 type .All these indicated that the homology of E .granulosus from the two regions were high and the genotype were G1 type ,which provided an important basis for the determination of strains ,and it al-so had a great significance to prevent and control the disease .

Objective To evaluate the efficacy and safety of domestic human recombinant FSH (rhFSH) in women with anovulation of WHO groupⅡ. Methods A randomized, blind, parallel-controlled, non-inferiority and multicenter study was performed. A total of 534 admitted to 13 hospitals from May 2008 to August 2009. There were 531 women with ovulatory disorder was included in the statistical analysis, were randomly divided into test group (domestic rhFSH, n=352) and control group (imported rhFSH, n=179). Percentage of cycle with mature follicle, ovulation rate, clinical pregnancy rate, multiple pregnancy rate, ovarian hyperstimulation syndrome (OHSS) and adverse events were observed. Results No statistical significant differences (P>0.05) were observed between the two groups in terms of the efficiency on mature follicle [91.8%(323/352) versus 88.8%(159/179)], ovulation rate [91.3%(295/323) verus 90.6%(144/159)], clinical pregnancy rate [19.2%(62/323) verus 18.2%(29/159)], the number of the follicles<14 mm, the level of serum LH and progesterone, the thickness of endometrium on the day of hCG administration. The number of follicle≥18 mm and 14 mm≤follicle<18 mm and the level of serum estradiol on the day of hCG in the test group were significantly higher than those in the control group (P<0.05). The number of days of rhFSH administration in the test group was significantly less than that in the control group [(9.8±2.2) versus (11.4± 0.6) days, P<0.05], the dosage of rhFSH was significantly lower than that in the control group [(879 ± 419) versus (1 043 ± 663) U, P<0.05]. The multiple pregnancy rate in the test group was significantly higher than that in the control group [21% (13/62) versu 10% (3/29), P<0.05]. The incidence of OHSS and adverse events were similar between the two groups (P>0.05), and no other adverse events were observed in test group during treatment. Conclusion Ovarian stimulation with domestic rhFSH is effective, safe and economical in women with anovulation of WHO groupⅡ.

Objective To explore the intervention effect of liaison nurses on the follow-up care of patients transferred out of the intensive care unit. Methods Totally 156 ICU patients from January to December 2016 were selected as the research object by convenient sampling, with 71 patients from January to June as the control group and 85 patients from July to December as the treatment group. Patients in the control group received conventional transfer, while a team of ICU liaison nurses was established to provide continuing nursing services to the patients transferred from ICU into general wards in terms of the treatment group so that potential risks could be found and intervened as early as possible. The average length of stays, rate of unexpected return to ICU within 48 hours, and incidence of nursing complications were compared between the two groups. The State Anxiety Inventory and Chinese Version of Critical Care Family Satisfaction Survey were used to compare the level of transfer anxiety and family satisfaction of the patients in the two groups. Results The patients in the treatment group showed a shorter average length of stays and a lower rate of unexpected return to ICU within 48 hours and incidence of nursing complications than the patients in the control group (P<0.05). The patients in the treatment group had a lower score in transfer anxiety (P< 0.05). The score in any dimension of family satisfaction and the total score of the patients in the treatment group were higher than those of the patients in the control group (P<0.05). Conclusions Liaison nurses have showed a good effect on the follow-up care of patients transferred out of ICU, which is significant to some extent.

Objective To explore the application of peer-assisted learning and mind map training model in the pre-job operation training of new nurses and evaluate its effect. Methods Totally 56 new recruited nurses of 2015 in a hospital were selected as the experimental group by cluster sampling from July 2014 to July 2015. While 49 new recuited nurses of 2014 were selected as the control group. Traditional training methods was used in the control group and the peer-assisted learning and mind map training methods were used in the experimental group. The operation score in two groups were compared, and the critical thinking ability of nurses in two groups were evaluated by the critical disposition dability inventory of nursing education. Nurses in the experimental group evaluated the peer-assisted learning and mind map training methods. Results After training, the operation score of nurses in the control group was (89.60±2.04), and the operation score in the experimental group was ( 92. 70 ± 2. 90 ) ( t=6. 57, P<0. 01 ) . The total score of nurses′ critical thinking ability in the experimental group was (319.26±3.30), while it in the control group was (298.72±1.39) (t=11.60,P<0.01). In the experimental group, 91.0% of nurses thought that this model was helpful to enhance communication ability and cooperation, while 83.9% of nurses thought that this model was helpful to remember the complex operation process. Conclusions The peer-assisted learning and mind map training model can improve the effects of pre-job operation training of nurses.

Objective:To construct a continuous nursing program for stroke patients with disability, so as to provide guidance for continuous nursing after discharge.Methods:The service program was initially developed based on the literature analysis by retrieving China National Knowledge Infrastructure (CNKI) , WanFang Data, VIP, PubMed, Cochrane Library and Ovid Database, and the retrieval time limit was as of October 31, 2019. On the basis of literature search and analysis, an expert consultation questionnaire was initially drawn up. Following the principles of informed consent and voluntariness, a total of 18 experts were finally selected for two rounds of expert consultation to construct the continuous nursing program for stroke patients with disability.Results:In the first round of expert consultation, a total of 18 expert consultation questionnaires were issued and 17 valid questionnaires were returned with the coefficient of expert motivation of 94.44%. In the second round of expert consultation, a total of 18 expert consultation questionnaires were issued and 18 valid questionnaires were returned with the coefficient of expert motivation of 100.00%. The mean value of the coefficient of motivation for the two rounds of expert consultation was 97.22%. The judgment basis coefficient of two rounds of expert was 0.80, the familiarity coefficient was all 0.79, and the authority coefficient of this study was 0.80. After two rounds of expert consultation, a three-level linkage management continuous nursing program for stroke patients with disability was finally formed, with 4 key time points and a total of 61 items.Conclusions:The results of this study are reliable, and the formed program can provide a reference for the development of continuous nursing research and practice for stroke patients with disability.