60 mmHg), indicating that the increase in pulse pressure participates in the course of myocardial hypertrophy. ⑤There was no significant correlation between pulse pressure and serum IGF-1 concentra tion, suggesting that different mechanisms are involved in the development of my ocardial hypertrophy between pulse pressure and IGF-1.

ObjectiveTo investigate the relationship between the social disability and emotion disorder of the patients with irritable bowel syndrome (IBS). Methods168 patients with IBS were assessed with Social Disability Screening Schedule (SDSS), Hamilton Anxiety Rating Scale, and Hamilton Depression Rating Scale. The patients with SDSS≥2 were divided into 2 groups, and accepted the medical routine therapy and explanatory psychotherapy for 2 months, while the patients in the research group (n=35) received the antidepressive. Then they were assessed with SDSS again. ResultsThe incidence of social disability in IBS patients was 40.5%, and increased in those who combined with anxiety and/or depression. The SDSS score of the research group was lower than that of the control group after the treatment. ConclusionThe social disability can be found in the patients of IBS, especially in those with emotion disorder, and can be improved by the antidepressive.

Objective To explore the efficacy of triple therapy and sequential therapy in the eradication of Helicobacter pylori (Hp) in patients receiving long-term non-steroidal antiinflammatory drugs (NSAID) treatment.Methods Patients receiving long-term NSAID treatment were enrolled in this study.Patients diagnosed as Hp infection were divided into triple therapy and sequential therapy groups.The patients in triple therapy group received omeprazole,clarithromycin and amoxicillin theray for 10 days.The patients in sequential group received esomeprazole with amoxicillin for five days,and then esomeprazole with clarithromycin and metronidazole for another five days.All patients were given mucosal protective therapy as maintenance treatment after eradication therapy and followed up for 12 weeks.Patients underwent endoscopy examination and Hp testing before and after follow-up.Hp eradication rates were compared with the intention-to-treat (ITT) and per protocol (PP) analysis.Results According to ITT analysis,the eradication rates of Hp in triple therapy group and sequential therapy group were 78.4 ％ (40/51) and 80.0 ％ (40/50) respectively,there was no significant difference between these two groups (x2 =0.038,P=0.846).According to PP analysis,the eradication rates of Hp in triple therapy group and sequential therapy group were 84.4％ (38/45) and 87.0％ (40/46) respectively,there was no significant difference between these two groups either (x2=0.117,P=0.732).Conclusion There was no significant difference in Hp eradication between triple therapy and sequential therapy in patients receiving long-term NSAID treatment.