1.Clinical study on the treatment of radiodermatitis with acupoint massage and wet compress of Chinese medicine
Yumei XING ; Xiuna YU ; Yuanfang JIANG ; Chao SUI
International Journal of Traditional Chinese Medicine 2010;32(5):427-
Objective To study the clinical effects of treating radiodermatis with acupoint massage and wet compress of Chinese medicine. Methods 104 patients with radiodermatis were randomly recruited into a control group and a treatment group, with 52 patients in each group. The treatment group was treated with acupoint massage plus wet compress of chiense medicines; with the treatment group was externally applied with Kangbao Shaoshang moistening ointment. The result was compared after the treatment. Results The time for easement of pain in the treatment group was obvious reduced than the control group after the treatment. The total effective rate was 96.1% and 57.69% in the treatment group and the control group respectively, the difference showing statistical significance (χ2=27.3, P<0.01). Conclusion It was effective to treat radiodermatitis with acupoint massage and wet compress of Chinese medicine.
2.Validity and reliability of the Chinese Attention to Positive and Negative Inventory in college students
Qin DAI ; Zhengzhi FENG ; Shuang XU ; Junrun XIE ; Keyu LIU ; Yongju YU ; Xiaoxia WANG ; Rui ZHANG ; Ying HE ; Jiawen LI ; Jing LI ; Yunbo LIU ; Xiuna LIU ; Cuihua ZHANG ; Leifei WANG ; Xiaoxia YANG ; Qiuping GAO ; Zailing HAN
Chinese Mental Health Journal 2015;(5):395-400
Objective:To translate the Attention to Positive and Negative Inventory(APNI)and analyze the validity and reliability in Chinese undergraduates sample,to offer a convenient and reliable tool of measuring the cognitive bias for national researchers. Methods:The English-version APNI went through translation into Chinese, retroversion into English,translation into Chinese again,and revision several stages. Two parts of samples (1450 Chinese college students)were surveyed. Sample one (n=1000)was used for item analysis,exploratory factor a-nalysis (EFA),concurrent validity and reliability analysis,while sample 2 (n=450)was used for confirmatory fac-tor analysis (CFA). Totally 68 subjects of sample 1 were randomly chosen and resurveyed with an interval of one week. Beck depression inventory (BDI-II)and patient health questionnaire (PHQ-9)was used for concurrent validi-ty. Results:Item analysis indicated that the 22 items of Chinese APNI had good discriminability. EFA focused onattention to positive information(API)and attention to negative information(ANI)two factors. CFA showed good model fit (χ2 =1376,RMESA=0. 09,CFI=0. 94). Concurrent validity result showed that the total scores of BDI-II and PHQ-9 was negatively correlated with total scores of API (r=-0. 24,-0. 29,Ps<0. 01 ),and posi-tively correlated with total scores of ANI (r=0. 36,0. 31,Ps<0. 01). The Cronbach'αcoefficients of API and ANI sub-scale were 0. 86 and 0. 82,while the retest reliability coefficients were 0. 79 and 0. 62. Conclusion:It suggests that the Chinese APNI has good validity and reliability in a sample of college students,which could be used to eval-uate the cognitive bias of Chinese college students.
3.Cryo-EM structures of a prokaryotic heme transporter CydDC.
Chen ZHU ; Yanfeng SHI ; Jing YU ; Wenhao ZHAO ; Lingqiao LI ; Jingxi LIANG ; Xiaolin YANG ; Bing ZHANG ; Yao ZHAO ; Yan GAO ; Xiaobo CHEN ; Xiuna YANG ; Lu ZHANG ; Luke W GUDDAT ; Lei LIU ; Haitao YANG ; Zihe RAO ; Jun LI
Protein & Cell 2023;14(12):919-923
4.High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors.
Yao ZHAO ; Xiaoyu DU ; Yinkai DUAN ; Xiaoyan PAN ; Yifang SUN ; Tian YOU ; Lin HAN ; Zhenming JIN ; Weijuan SHANG ; Jing YU ; Hangtian GUO ; Qianying LIU ; Yan WU ; Chao PENG ; Jun WANG ; Chenghao ZHU ; Xiuna YANG ; Kailin YANG ; Ying LEI ; Luke W GUDDAT ; Wenqing XU ; Gengfu XIAO ; Lei SUN ; Leike ZHANG ; Zihe RAO ; Haitao YANG
Protein & Cell 2021;12(11):877-888
A new coronavirus (SARS-CoV-2) has been identified as the etiologic agent for the COVID-19 outbreak. Currently, effective treatment options remain very limited for this disease; therefore, there is an urgent need to identify new anti-COVID-19 agents. In this study, we screened over 6,000 compounds that included approved drugs, drug candidates in clinical trials, and pharmacologically active compounds to identify leads that target the SARS-CoV-2 papain-like protease (PLpro). Together with main protease (M
Antiviral Agents/therapeutic use*
;
Binding Sites
;
COVID-19/virology*
;
Coronavirus Papain-Like Proteases/metabolism*
;
Crystallography, X-Ray
;
Drug Evaluation, Preclinical
;
Drug Repositioning
;
High-Throughput Screening Assays/methods*
;
Humans
;
Imidazoles/therapeutic use*
;
Inhibitory Concentration 50
;
Molecular Dynamics Simulation
;
Mutagenesis, Site-Directed
;
Naphthoquinones/therapeutic use*
;
Protease Inhibitors/therapeutic use*
;
Protein Structure, Tertiary
;
Recombinant Proteins/isolation & purification*
;
SARS-CoV-2/isolation & purification*