18F-FDG PET-CT is of great significance in non-small cell lung cancer diagnosis, staging, treatment options, efficacy evaluation and prediction of prognosis. But it has non-specificity, and its application is limited. In recent years, a number of new non-18F-FDG imaging agents is constantly developed and used clinically, which contributes to the PET -CT's further development and application in lung cancer.

Objective To compare therapeutic effect of Losartan and hydrochlorothiazed compound prepara- tion and Losartan in patients with mild to moderate hypertension and to conduct economical evaluation. Methods The trial began with 2 weeks lead-in period and followed by 8 weeks therapy. 99 cases of mild to moderate hyperten- sion were randomly divided into two groups: compound preparation group ( n = 50) and Losartan (n = 49). The pa- tients were given Losartan 50 mg/h ydrochlorothiazed 12.5 mg compound preparation and Losartan 50 mg ,once a day. If the SeDBP≥85 mm Hg at 4th week, Losartan was added to 50 rag. Results After two, four and eight weeks treatment, systolic blood pressure and diastolic decreased obviously (P < 0.01 for each) ;The overall effective rate of of antihypertension was the same in both groups, but the different ratio of availability and validity in two groups was significant ( P < 0.05 for each). Conclusion Losartan/hydrochlorothiazed compound preparation has significant advantage in improving both systolic and diastolic pressure compared with monotherapy of Losartan. In ad- dition, the patients receiving compound preparation are well tolerated, with higher compliance.

Objective To investigate the inpatients' evaluation of quality nursing care and disucss different data collecting methods on patients's evaluation of quality nursing care. Methods Patients measure up to standard (82 cases) were divided into the questionnaire group and the interview group with 41 patients in each group. The questionnaire investigation was carried out in the questionnaire group by applying 4 themes of quality nursing care. The interview group used structured interview instead. The results of the two methods were compared and analyzed. Results The score of quality nursing care of the questionnaire group was higher than that of the interview group (P<0.01) in evaluating health education method. In humanistic environment patients in the questionnaire group thought nurses could protect their privacy, respect their personality and treat them and their family members kindly. Besides visiting institution was reasonable. All of these were the demonstration of quality nursing care. The above results were different from those of the interview group (P<0.01). Conclusions Patients had comprehensive requirement on quality nursing care. Nurses should, use this as reference, regulate their service behavior and improve nursing quality.

OBJECTIVE:To provide reference for improving the breast cancer patients’medication compliance. METHODS:280 inpatients with advanced breast cancer who had received endocrine therapy in a hospital ward of chemotherapy of breast from Sept. to Nov. 2015 were selected,questionnaires was combined with on-site interview to investigate and analyze the medication com-pliance,influential factors and adverse reactions induced by endocrine drugs. RESULTS:Among the 280 patients,161 (57.5%) showed good medication compliance,64(22.9%)were general and 55(19.6%)were poor;its medication compliance were mainly affected by“wrong understanding on disease control (27.2%)”“adverse drug reactions (22.4%)”“forgetting taking medicines (21.1%)”;the common adverse reactions of endocrine therapy included hot flashes,mood disorders and joint pain. CONCLU-SIONS:Clinical pharmacists,especially the specialists should give full play to their own professional advantage,strengthen patient medication education,actively participate ward round and follow-up,improve breast cancer patients’compliance on endocrine therapy.

The DNA microarray study showed that in STZ-induced diabetic rats the elevatedexpression of 42 genes in artery were depressed markedly after atorvastatin treat ment .This suggeststhat atorvastatin may have the protective effects on the diabetic vascular lesion.

Objective To investigate the utility of full-field digital mammography (FFDM) and localization and biopsy in diagnosis of nonpalpable breast cancer. Methods 42 cases with suspect breast cancer by routine film reading but negative clinical palpation were performed localization and biopsy under X-ray orientation and diagnosed with breast cancer by pathology. The characters of those cases were studied.Results Among 42 cases, 5 cases showed micronodules, 8 cases demonstrated local dense infiltration, 11cases had architecture distortion, 18 cases demonstrated micro-calcifications. The type of pathology comprised of intraductal carcinoma (23 cases), tabular carcinoma in situ (2 cases), early infiltration of ductal carcinoma (12 cases), infiltrating ductal carcinoma (3 cases), papilloma carcinoma (2 cases). Conclusion FFDM can clearly show direct and indirect X-ray signs of breast cancer, combined with localization and biopsy the nonpalpable breast cancer can be easily diagnosed.

Objective To explore the cost of healthcare-associated infection (HAI)management in a tertiary first-class hospital,provide data support for cost-effectiveness and cost-benefit analysis of HAI management,and provide scientific evidence for the rational allocation of hospital resources.Methods Micro-costing study was used to calcu-late the direct cost of the department of HAI management by collecting the quantity and unit price of each item. Results The total cost of HAI management in this hospital in 2013 were about ￥870 000,including human cost￥790 000,depreciated fixed assets ￥34 501 ,low-value consumption goods ￥3 800,publicity and training￥33 600,office consumables ￥5 208;average cost were ￥12.16 per person and ￥529.69 per bed.Conclusion Human cost is the main cost in HAI management in this hospital.

Objective To study the improvement in the surgical technique of vaginal hysterectomy and salpingo-oophorectomy. Methods The LigaSure TM System has been used in vaginal hysterectomy and salpingo-oophorectomy in 582 patients of group one. The result was compared with the 430 patients of group two, for whow the operation was done by the same medical team in our hospital using the traditional technie, in order to evaluate the two techniques. Results With a smaller incision in the new method, thus the time of operation was shorter, the amount of blood loss was less, post-operative hospital stay days were less, and post-operative complication was less (P

Paired box2 ( PAX2 ) is a transciption factor which mainly expressed in the developing kid-ney. Researches indicate that PAX2 promote the transcription through interactions with the adaptor PAX transac-tivation domain interacting protein(PTIP). Otherwise,PAX2 protein can lead to chromatin compaction and gene silencing through interactions with Grg4. PAX2 reexpressed in acute kidney injury and involved in promoting cell proliferation. Congenital PAX2 gene mutation is closely related to congenital abnormalies of the kidney and uri-nary tract. In chronic kidney disease,PAX2 promote proliferation and cyst formation. Here,the recent researches on the function of PAX2 and its role in acute kidney injury and chronic kidney disease are reviewed.

OBJECTIVE:To provide references for rational clinical application of human serum albumin. METHODS:By adopting retrospective analysis,medical records of 256 tumor inpatients administered with human serum albumin in the affiliated cancer hospital of zhengzhou university during Jan. and Jun. 2014 were randomly selected to statistically analyze the drug consump-tion amount per capita,average course of treatment and the concentration of serum albumin in the patient before administration. RE-SULTS:In our hospital,human serum albumin was used in 15 clinical departments,mainly in non-surgical departments. The pa-tients received drugs at a single dose ranging from 10 to 20 g. Postoperative patients with hypoalbuminemia topped the list in terms of daily consumption amount of human serum albumin(15.82 g/d)and patients with hypoalbuminemia accompanied by ascites and pleural effusion experienced the longest average course of treatment(6.93 d). Human serum albumin was mainly used for hypopro-teinemia. CONCLUSIONS:The use of human serum albumin in our hospital conformed to the dispensatory and the regulations on the medical insurance organizations of Henan Province. However,it is not in compliance with the regulations on the medical insur-ance organizations of Beijing and the guidelines of the hospital associations of American universities. Therefore,the indication of human serum albumin needs to be further defined,and priority should be given to nutrition supply for the inpatient with hypoalbu-minemia caused by malnutrition.