Objective:To evaluate pediatric cataract operative cases,especially traumatic cataract patients,through operative skill,intraoperative complications and their managements,postoperative vision and complications.Methods:108 eyes of 82 pediatric patients,who were diagnosed as developmental,congenital,traumatic,and after-cataract with age ranged from 2 to 14 years old,were performed cataract extraction combining with intraocular lens implantation.Analysis were carried out based on postoperative vision,intra-postoperative complications and managements.Results:102 eyes got better vision postoperatively than before.Main intraoperative complications were posterior capsular rupture and prolapse of vitreous,and main postoperative complications were posterior capsular opacity(PCO),inflammatory reaction of anterior chamber,etc.Conclusion:Cataract extraction combining with intraocular lens implantation through sclera tunnel incision is an effective method for the pediatric patients whose age was over 2 years old.There exists special postoperative complications in pediatric patients and appropriate managements at the right moment ensure satisfactory effects.

Objective:To study the operative skill and clinical outcome of double eyelid operation on the treatment of various upper eyelid entropion and trichiasis.Methods:330 patients (640 eyes)with various upper eyelid entropion and trichiasis underwent modified double eyelid operation combining with correction of entropion.Results:There were 313 satisfactory cases(94.85%),14 improved cases(4.21%),and only 3 ineffective cases(0.91) obtained from follow-up.Conclusion:It is suggested that modified double eyelid operation not only can treat eye disorders through correcting upper eyelid entropion and trichiasis,but get good plastic effects as well.

Objective:To study the changes of cytochrome oxidase (CO) activity in retina of monocular deprived rats.Methods:Deprived amblyopia rat model were established by suturing the eyelids of observed eye of 14 days old rats for one month.The retina stretched preparation were processed with CO histochemical reaction and the number of CO positive retina ganglion cells were studied under light microscope.Results:The number of CO positive retina ganglion cells decreased in deprived eyes compared with control eyes( P

Objective:To investigate the operative skill of phacoemulsification for cataract patients,to explore the best access at early learning stage and to study the related complications.Methods:Learning included attending lectures (theoretical study),animal experiments and case selections.97 consecutive cases(100 eyes) of early stage patients underwent phacoemulsification under peribulbar anaesthesia,continuous curvilinear capsulorhexis(CCC)or open capsulotomy,hydrodissection or hydrodelineation,one or two had nuclear phacoemulsification and IOL implantation.Results:During the first and second half of learning stage,CCC were performed successfully in 38%and 74% of the cases respectively;furthermore the incidences of posterior capsuletearing were 30% and 12% respectively.63 eyes (53%) with postoperative corrected visual acuities over 0.5 were observed. Conclusion:CCC method with maintenance of anterior chamber and emulsification within capsule must be adopted,furthermore posterior capsule tearing and corneal edema should be prevented.Phacoemulsification could be a safe procedure even during the learning curve by means of learning step by step,training followed an appropriate programme,selecting the suitable cases and managing complications correctly.The successful transition to phacoemulsification would be completed.

Objective To investigate the clinical significance of the changes of electrocardiogram (ECG) and cardiac markers for myocardial damage after on-pump coronary artery bypass grafting (CABG) and off-pump coronary artery bypass grafting (OPCABG). Method Monitoring 25 patients of OPCABG (OPCABG group) and 25 patients of CABG (CABG group) R wave amplitude of V4 and V5 on antorior electrocardiographic lead and simultaneously determining cardiac markers for myocardial damage creatine phosphokinase isoenzyme MB (CPK-MB), tropenin I (cTnI) and heat-shock protein 70 (HSPT0) on different lime. Results R wave amplitude of V4 and V5 on anterior electrocardiographic lead had no significant changes on 0, 6, 18 and 24 hours after OPCABG. On the contrary, R wave amplitude of V4 and V5 on anterior electrocardiographic lead decreased significantly on 0, 6 and 18 hours after CABG (P<0.01), and came back to preoperative values 24 hours after operation. The levels of CPK-MB and cTnI reached its peak and higher significantly for CABG than those for OPCABG on 24 hours after operation, 29.29 μg/L vs 5.98 μg/L and 6.74 μg/L vs 1.91 μg/L respectively. HSP70 increased significantly on 6 hours after operation in two groups, but median of HSP70 was higher significantly in CABG group (11044.5 pmol/L vs1702.0 pmol/L). In the first day after operation the HSP70 peak was correlated significantly with the level of CPK-MB(r=0.370, P<0.01) and cTnI (r=0.458,P<0.01). Conclusions Myocardial damage is significantly alleviated for patients of OPCABG comparing with those of CABG. The HSF70 in circulation may indicate the degree of myocardial damage.

(0.05)).And there were no side effects in two groups. CONCLUSION: The Yinqiao Tablet is effective and safety in treating wind-type common cold.

AIM: To explore the inhibitory effect of honokiol on retinal NV. METHODS: Hyperoxia was induced in NV model in 60 mice.Twenty mice received an intraperitoneal injections of 100 mg/kg honokoil twice daily for 5 days as large-dosage group and 20 mice received 50 mg/kg as small one while 20 mice received BSS as control.The collagen IV immunohistochemical staining was used to observe retinal vessels.The effect was evaluated by counting the nuclei extending from retina to vitreous and expressions of VEGF and MMP-2. RESULTS: The reduced density of vessels in the treatment group were found in retinal.The number of nuclei was less in the treated groups,which in the lagre-dosage group was significantly less.The expressions to VEGF and MMP-2 were less in the treatment than in the control respectively.That in the large-dosage group was significantly less. CONCLUSION: Intraperitoneal injections of honokoil can effectively inhibit retinal NV,depending on dosage.

Aim To observe the protective effects of choline and pilocarpine,the M3 receptor agonists,on the arrhythmias of Wistar rats induced by barium chloride.Methods Barium chloride was used to induce the experimental arrhythmias of Wistar rats.Choline,pilocarpine,and 4-diphenylacetoxy-N-methylpiperidine-methiodide (4-DAMP),the selective antagonist of M3 receptor,were used to explore the effects of M3 receptor on the arrhythmias induced by barium chloride.The occurence and the severity of arrhythmias were observed.Results Choline 10 mg?kg-1 and pilocarpine 0.2 mg?kg-1 inhibited the occurence of arrhythmias,shortened the duration of arrhythmias (P

Objective:To investigate the clinical manifestations and pathogenic gene mutation sites of familial cavernous hemangioma by a pedigree study of this disease.Methods:A family of cerebral cavernous hemangioma who was admitted to the Department of Neurology of the First Affiliated Hospital of Henan University of Science and Technology in April 2019 was diagnosed as cerebral cavernous hemangioma type 1 based on clinical manifestations and head magnetic resonance imaging (MRI), diffusion weighted imaging and susceptibility weighted imaging screening. According to Zabramski classification criteria, the family′s clinical data were collected and genes were sequenced.Results:A 58-year-old female proband had dizziness and headache as the main symptoms, her daughter and son had no clinical symptoms, and her granddaughter had clinical manifestations of cerebral hemorrhage and seizures. The proband and her family members showed multiple cavernous hemangioma on cranial MRI,and the p.L436fs mutation in the KRIT1 gene of familial cerebral cavernous malformation type 1 was confirmed through genetic examination, which was consistent with the Zabramski typing results based on head MRI. The mutation site of the familial spongiform malformation type 1 pathogenic gene was found to be p.L436fs in KRIT1 gene, which has not been reported in familial cerebral cavernous hemangioma type 1 until now.Conclusion:A new p.L436fs mutation of KRIT1 gene was found in familial cerebral cavernous malformation type 1, which expands understanding of the clinical manifestations and pathogenic gene mutation sites of familial cavernous hemangioma.

Objective: To study the shift of oVEMP frequency tuning of unilateral Meniere′s disease, by analyzing oVEMP of air-conducted tone bursts in various frequencies. Methods: From May 2016 to October 2017, 33 patients with unilateral Meniere′s from Aerospace Center Hospital were tested for oVEMP in 500 Hz and 1 000 Hz air-conducted tone bursts respectively, and 20 healthy subjects(40 ears), matched for age and sex, were used as healthy control. The amplitudes of the N1-P1 wave and the frequency amplitude ratios of 500/1 000 Hz in affected ears, unaffected ears and normal ears were compared; and receiver operating characteristic curve was analyzed for frequency amplitude ratios of 500/1 000 Hz. Results: By the 500 Hz tone-burst stimulus, the provocation rates of the oVEMP were 84.9%(28/33), 93.9%(31/33) and 97.5%(39/40) in affected ears, contralateral ears and the ears of normal controls, respectively. By the stimulus of 1 000 Hz tone-burst, the provocation rates of the oVEMP were 81.8%(27/33), 87.9%(29/33) and 82.5% (33/40) in affected ears, contralateral ears and normal control ears, respectively. Amplitudes of N1-P1 waveforms in 500 Hz air-conducted tone bursts in affected ears were under normal control ears and contralateral ears. There was significant difference between affected ears and healthy control ears (P<0.05). Amplitudes of N1-P1 waveforms in contralateral ears were also significantly smaller than those in normal control ears (P<0.05). There were no significant differences in amplitudes of N1-P1 waveforms between affected ears, contralateral ears and normal control ears in 1 000 Hz tone bursts stimulus(P>0.05). Frequency amplitude ratios of 500/1 000 Hz in affected ears were significantly under contralateral and normal control ears (P<0.05). According to ROC, the frequency amplitude ratio critical value of frequency tuning was set as 1.17, the positive rate of frequency tuning shift in affected ears was 54.5%(18/33) and significantly higher than in contralateral ears(18.2%, 6/33, χ²=9.429, P=0.002) and normal control ears (7.5%, 3/40, χ²=19.530, P=0.000). In contrast, there was no significant difference in the incidence of frequency tuning shift between contralateral ears and normal ears(χ²=1.909, P=0.167). Conclusions Frequency tuning oVEMP with Meniere′s disease will be changed.Frequency tuning of oVEMP with Meniere′s disease shifts from low frequency region to high frequency region in comparison with healthy people. Frequency amplitude ratio is helpful for diagnosis of Meniere′s disease.