Objective To analyze the viral infection in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD)and its clinical significance.Methods 350 patients with acute exacerbation of COPD were collected.The viral infection and clinical manifestations,pulmonary function and imaging features were detected and analyzed.Results A total of 104 patients with viral infection,the proportion was 29.7%.Single virus infection in 74 cases(71.2%),the highest proportion was FluB(19.2%)in pathogen type,followed by FluA(15.4%).Multiple virus infection in 30 cases(28.8%),the highest proportion was RSV+FluB(11.5%).The virus infection in patients with sore throat(20.2% vs.6.9%),lung function grade(32.7% vs.20.3%),presence of pulmonary inflammatory lesions(57.7% vs.40.7)and the death rate(12.5% vs.0.8%)were significantly higher than those of the combined group of virus infection,the proportion of lung function was significantly lower than patients without viral infection,the differences were statistically significant(x2=6.546,5.477,4.987,4.124,3.997,all P<0.05).The proportion of respiratory failure in patients with acute COPD infection was 86.5%,which was higher than 62.6% of patients without viral infection,the difference was statistically significant(x2=19.837,P<0.05).Conclusion Acute exacerbation of COPD has a high proportion of virus infection,and the prognosis of patients is poor.

Objective To investigate the prostecdtive efficacy of one-stage bone grafting in man-aging chronic osteomyelitis after debridement.Methods From March 1999 to May 2003, 79 patients with chronic osteomyelitis including 28 patients with nonunion underwent one-stage autogenous bone graft-ing, allografts or mixed bone grafting after debridement in Nanjing General Hospital of Nanjing Military Command.All patients were followed up for a mean period of 77 months (60-111 months).Results Six patients (8%) , including two with autogenous bone grafting, three with allografts and one with mixed bone grafting, were confirmed with recurrence of infection, with no statistical difference among three methods of bone grafting.Of 28 patients with nonunion, 23 patients with autogenous bone grafting and two with allografting obtained union, the other three patients with mixed bone grafting obtained union in two patients but resulted in recurrence of infection with nonunion in one, with cure rate of 96% (27/28).Conclusions One-stage bone grafting after debridement for infection and bone union can reach cure rate of over 90%.The recurrence of infection mostly occurs within the first year after operation, with stable long-term curative effect.

Objective To investigate the effect of inhalation of budesonide combined with ambroxol hydrochloride in the treatment of chronic obstructive pulmonary disease ( COPD ) in acute exacerbation stage . Methods 60 patients with acute exacerbation of COPD treated in the Department of respiratory medicine of Zhenhai People's Hospital from January 2013 to December 2015 were selected as the research subjects in Ningbo , and they were randomly divided into control group and observation group according to the digital table ,with 30 cases in each group.The control group received routine treatment, the observation group was given budesonide and ambroxol hydrochloride inhalation on the basis of conventional therapy .After 1 week of treatment ,the clinical efficacy indicators of pulmonary function,arterial blood gas analysis index,time of symptoms were compared between the two groups . Results The total effective rate of the observation group was 100.0％,which was higher than 83.3％of the control group (χ2 =5.455,P<0.05).After treatment,the forced expiratory volume in one second (FEV1),the ratio of FEV1 and forced vital capacity (FVC) (FEV1/FVC),arterial partial pressure of carbon dioxide (PaCO2),arterial oxygen pressure (PaO2) in the observation group were (2.09 ±0.69)L,(58.94 ±15.67)％,(35.08 ±3.79)mmHg, (85.92 ±4.97)mmHg,respectively,which in the control group were (1.43 ±0.57)L,(43.12 ±11.03)％,(48.47 ± 4.24)mmHg,(79.54 ±4.56)mmHg,respectively,the differences between the two groups were statistically significant (t=4.039,4.522,12.896,5.181,all P<0.05).The remission time of shortness of breath ,cough,expectoration in the observation group were (2.04 ±0.86)d,(4.49 ±1.25)d,(4.56 ±1.34)d,respectively,which were shorter than those in the control group [(3.36 ±1.08)d,(6.53 ±1.82)d,(6.78 ±1.91)d],the differences between the twogroups were statistically significant (t=5.237,5.061,5.212,all P<0.05).Conclusion Inhalation of budesonide combined with ambroxol hydrochloride in the treatment of acute exacerbation of COPD can effectively improve the treatment effect , and the pulmonary ventilation function and arterial blood gas status , and shorten the time of remission,and is benefit to disease control .

Objective:To understand the basic situation of medicinal plants in Qing'an county, such as the type, distribution and life form, etc., to scientifically formulate a planting plan for Chinese medicinal materials for Qing'an county.Methods:Guided by the Implementation Plan of the Fourth National Survey of Traditional Chinese Medicine Resources (Pilot) and the Technical Specifications of the Fourth National Survey of Traditional Chinese Medicine Resources, the resources of medicinal plants in Qing'an county were investigated through on-site surveys, interviews, the results are entered into the census system, and data analysis is performed. Results:A total of 380 species of 243 genera and 83 families of wild medicinal plants were recorded, there are 310 kinds of herbs, accounting for 81.58% of the total medicinal plants. There are 70 woody species, accounting for 18.42% of all medicinal plants. There are 10 dominant families (including more than 10 species) in Qing'an county, accounting for 49.40% of the total genera and 52.89% of the total species. The top three ranked species of wild medicinal plants in Qing'an county are China-Japan, temperate Asia, and Northeast China, including 150 species, accounting for 39.47%.Conclusions:The resource survey basically clarified the basic situation of traditional Chinese medicine resources in Qing'an county, and has guiding significance for the next step of conducting a general survey of traditional Chinese medicine resources. The results of the survey also provided support for local science knowledge and development of traditional Chinese medicine.

Objective To observe the value of MRI in evaluation on the morphology and function of iliococcygeal muscles in fertile and nulliparous women.Methods Totally 50 healthy fertile women (fertile group,further divided into cesarean section subgroup and spontaneous delivery subgroup according to the mode of delivery) and 17 nulliparous healthy women (nulliparous group) underwent MR scanning in both natural and increased abdominal pressure state.Iliococcygeus thickness (ICT),coronal iliococcygeal angle (cICA) and sagittal iliococcygeal angle (sICA) of different states were measured and compared between the groups.Results In the natural state,the right and bilateral average sICA in the fertile group were larger than those in nulliparous group (both P＜0.05),while no statistical difference of ICT,right,left and bilateral average cICA and left sICA were found between two groups (all P＞0.05);the bilateral average sICA in spontaneous delivery subgroup was larger than that in cesarean section subgroup (P＜0.05).In increased abdominal pressure state,left,right sICA and bilateral average sICA in fertile group were larger than those in nulliparous group (all P＜0.05),while there was no statistical difference of ICT and cICA between two groups (all P＞0.05);no statistical difference of ICT,cICA nor sICA was found between spontaneous delivery subgroup and cesarean section subgroup (all P＞0.05).Conclusion MRI can accurately evaluate morphological and functional changes of iliococcygeal muscle in females.

The hydroponic culture test method was used to study the physiological and biochemical responses of Paulownia fortunei seedlings under Zn stress, Cd stress, and combined Zn and Cd stress as well as changes in the enrichment and transfer characteristics of heavy metals. Under single and combined heavy metal stress, the biomass, plant height, and peroxidase (POD) activity of P. fortunei decreased as the treatment concentration increased. Combined Zn and Cd affected adversely plant height and biomass. As the concentration of Zn increased when applied alone, the chlorophyll content and catalase (CAT) activity of P. fortunei first increased and then decreased, the superoxide dismutase (SOD) activity increased, and the aboveground malondialdehyde (MDA) content first decreased and then increased. As the concentration of Cd increased when applied alone, chlorophyll content and CAT activity increased, and SOD activity and aboveground MDA content first increased and then decreased. Under both Cd and Zn, the physiological response was more complex. Cd in the seedlings of P. fortunei was concentrated in the root. In contrast, Zn was concentrated in the upper part of the ground, and its transfer coefficient was greater than 1.00. Thus, the addition of Zn promotes the transfer of heavy metals to the above-ground portions of plants. Generally, P. fortunei can effectively promote ecological restoration under complex forms of heavy metal pollution.
Cadmium ; Chlorophyll ; Metals, Heavy ; Plant Roots/chemistry* ; Seedlings ; Soil Pollutants ; Stress, Physiological ; Superoxide Dismutase ; Zinc