Objective To investigate clinical effect of sparfloxacin on the treatment of ureaplasma urealyticum prostatitis.Methods 96 cases with ureaplasma urealyticum prostatitis, which admitted in our hospital, were selected as the research object and divided into observation group ( n =48 cases) and control group ( n=48 cases) randomly.The control group was given the ofloxacin for treatment and the observation group was given the sparfloxacin for treatment.The clinical effect of the two groups after treatment was analyzed.Results The total effective rate of the observation group (97.92%) was significantly higher than that of the control group (72.92%) (P<0.05).After treatment, the total incidence of adverse reactions of the observation group(8.33%) compared with that of the control group (10.42%), had no significant difference(P>0.05).Conclusion Patients with ureaplasma urealyticum prostatitis, the treatment effect of sparfloxacin is significant, with lower adverse reactions rate and the security is higher, which is recognized in the medical community, can be worthy of popularization and application in clinic.

To investigate the effect of crocin on the progression and generalized seizure of temporal lobe epilepsy in mice.Hippocampus rapid kindling model was established in C57BL/6J mice. The effects of crocin on seizure stage, afterdischarge duration (ADD), number of stimulation in each stage and final state, the incidence of generalized seizure (GS), average seizure stage and ADD were observed.Crocin (20 mg/kg) significantly retarded behavioral seizure stages (<0.05) and shortened cumulative ADD (<0.01) during hippocampus rapid kindling acquisition in mice compared with vehicle group. Meanwhile, number of stimulations in stage 1-2 was significantly increased (<0.05) and the incidence of fully kindled animals was significantly decreased (<0.01). However, 10 or 50 mg/kg crocin showed no significant effect on the above indexes (all>0.05). Crocin (100 or 200 mg/kg) significantly decreased the incidence of GS (all<0.01) and reduced average seizure stages (all<0.01) in fully-kindled mice compared with vehicle group; Fifty mg/kg crocin only reduced average seizure stages (<0.05).Low-dose crocin can retard the progression in hippocampus rapid kindling acquisition in mice, while high-dose crocin relieves the GS in fully-kindled mice, which suggests that crocin may be a potential anti-epileptic compound.
Animals ; Anticonvulsants ; pharmacology ; Carotenoids ; pharmacology ; therapeutic use ; Dose-Response Relationship, Drug ; Electric Stimulation ; Epilepsy, Temporal Lobe ; chemically induced ; drug therapy ; Hippocampus ; drug effects ; physiopathology ; Kindling, Neurologic ; drug effects ; physiology ; Mice ; Mice, Inbred C57BL ; Seizures ; classification ; drug therapy