Objective To improve the accuracy of diagnosis and differential diagnosis of nonossifying fibroma (NOF) by comparing with the image features of X-ray and CT and pathological characteristics,Methods The images of X-ray and CT of 28 patients underwent surgery and pathological confirmed NOF were studied retrospectively.Results NOF often occurred in the metaphysis of long bone or backbone with mild clinical symptoms.Eighteen lesions occurred in tibia,9 in femur and 1 in humerus.In 19 cortical cases,there was a single room or multiple rooms translucent zone in cortex or subcortex with dense surrounding.In 9 medullary cases,lesions as a single room or multiple rooms ranslucent zone with dense surrounding developed in the central area of the bone with thinning corex slightly bulg ed to periphery.Conclusion The images of NOF have some characteristic.X-ray and CT are very useful tools in diagnosis of NOF.Thin layer scanning and multiplanar reconstruction of multi-layers spiral CT can more clearly show the imaging features of NOF.

Objective To evaluate the therapeutic effect of acute necrotizing pancreatitis(ANP) by the continuous intra-arterial infusion of stilamin,danshen and antibiotics using micro-pump. Methods 12 patients with ANP were treated with arterial infusion immediately after the patients were diagnosed by CT or MRI.The catheter was placed in the celiac artery.The drugs were used continuously for 3 to 9 days using micro-pumps.Results All of the 12 patients were recovery after 17 to 35 days treatment.No severe complications were observed.Conclusion The treatment of ANP by arterial infusion of stilamin,danshen and antibiotics offers good therapeutic effect with few severe complications and low mortality rate,it can shorten the duration of treatment and is proved to be an ideal method.

Objective To evaluate the diagnostic value of contrast-enhanced CT scans in diagnosis of traumatic splenic rupture. Methods The findings of unenhanced and contrast-enhanced CT scans of 34 cases with traumatic splenic rupture confirmed by operation were retrospectively reviewed. Results Of the 34 patients, the diagnoses of splenic rupture on unenhanced CT scans were certain in 23 patients and uncertain in 6 patients. No abnormalities were found in 5 patients(sensitivity 85.3%, specificity 67.6%). After intravenous administration of contrast material, all of the patients were diagnosed as splenic rupture(sensitivity 100%,specificity 100%).Conclusion Contrast-enhanced CT is important in diagnosis of traumatic splenic rupture and can obviously improve the diagnostic accuracy. It provides reliable information for clinical treatment.

AIM: To examine the expression of human endostatin in E.coli , produce its fusion protein antibody and observe its biological activity. METHODS: Endostatin gene was amplified by polymerase chain reaction,recombined with plasmid vector pGEX-2T and induced expression with IPTG.The protein activity was tested by endothelial cell proliferation inhibitory assay.Inclusion body crudely purified was used to generate polyclonal antibody to detect its expression at mouse's liver and kidney etc. RESULTS: The protein expressed was 20 kD after digestion by thrombin,it appeared the anti-angiogenesis activity and Western blotting indicated the expression of endostatin in liver and kidney of mouse. CONCLUSION: The successful expression of human endostatin and the preparation of polycolonal antibody indicated its potential application in anti-angiogenesis therapy and diagnosis tumors.

Objective:To investigate the clinical, imaging and endoscopic characteristics of idiopathic mesenteric phlebosclerosis (IMP).Methods:From January 2010 to December 2020, 14 patients with IMP diagnosed and treated at the Quzhou Hospital Affiliated to Wenzhou Medical University (Quzhou People′s Hospital) were enrolled. All patients underwent abdominal X-ray, contrast enhanced computed tomography (CT) and endoscopy. Three cases accepted double-contrast barium enema and 11 cases underwent endoscopic biopsy. Three of the 14 IMP patients underwent surgery and pathological examination because of intestinal perforation or intestinal obstruction that failed conservative treatment. The general data (such as gender, drinking history, etc.), clinical symptoms, complications, imaging (abdominal X-ray, CT, double-contrast barium enema) and endoscopic features were retrospectively analyzed. Descriptive method was used for statistical analysis.Results:Among the 14 IMP patients, 13 cases were male and one case was female. All the 13 male cases had long history of drinking Chinese herbal medicine wine, among them, 8 patients consumed acanthopanax bark wine. Complications occurred in 7 cases, including 5 cases of intestinal obstruction and 2 cases of intestinal perforation. The clinical symptoms of 14 IMP patients were nonspecific, mostly manifested as abdominal pain (11 cases), abdominal distension (6 cases), diarrhea (6 cases), nausea and vomiting (4 cases), and constipation (2 cases). Abdominal X-ray images mainly showed multiple irregular calcifications along involved colon. The images of 3 patients received double-contrast barium enema demonstrated shallowness or disappearance of semilunar folds, rigid colonic wall, narrowed lumen and " thumb printing". The typical CT images indicated edema and thickening of the involved intestinal wall, blurred mesenteric fat space, spot, thread-like, and curved calcification of mesenteric vein and colonic wall. Typical endoscopic findings included dark-purple colored mucosa, congestion, edema, erosion and ulceration, and focal nodular surface and visible varicose veins.Conclusions:IMP has typical imaging and endoscopic characteristics, and the combination of them can diagnose and evaluate IMP more accurately.