Objective To investigate better heating and thermal insulation methods of enteral nutrition solution by comparing different thermal insulation devices. Methods A total of 90 patients with continuous enteral nutrition support, in accordance with the random number table, were divided into 3 groups. Enteral nutrition solution was heated by three different methods. It included the heating infusion thermostat, the heating nutrition pump and the heating special insulation using medical liquid bag device, and to comparatively observe the temperature of nutrition solution of three groups in the nasal feeding tube before infusion finish, in addition, to comparatively observe adverse reaction in course of enteral nutrition support and calculate the cost of heating device. Results The percentage of nutrition solution with temperature during 35-40 ℃, the incidence rate of adverse reaction and the cost of heating device in the heating special insulation using medical liquid bag device was 100.00%( 30/30), 6.67%(2/30) and 1837.23 yuan while the heating infusion thermostat was 73.33%( 22/30), 33.33%(10/30) and 2079.46 yuan, and the heating nutrition pump was 0, 26.67% (8/30) and 2007.05 yuan. The difference among three heating devices was statistically significant (Z=48.50, P =0.000; χ2=6.69, P=0.038; F=17.87, P=0.000). Conclusions The heating special insulation using medical liquid bag device is good insulation effect, low cost and easy to handle, and is worth being popularized.