Objective To study the expressions of CA19-9 and CA125 and their clinicopathologic significances in gallbladder adenocarcinoma, pericancerous tissues and chronic cholecystitis. Methods EnVisionTM immunohistochemistry was used for assaying the expressive levels of CA19-9 and CA125 in the routinely paraffin-embedded sections of specimens from gallbladder adenocarcinoma (n=108), pericancerous tissues (n=46), and chronic cholecystitis (n=35). Results The positive rates of CA19-9 and CA125 were significantly higher in gallbladder adenocarcinoma (49.1%, 51.9%) than those in pericancerous tissues (26.1%, 15.2%) and chronic cholecystitis (14.3%, 5.7%), respectively (P

Objective To explore the diagnosis and treatment of regional pancreatic portal hypertension.(Methods) The clinical data of 11 cases of regional pancreatic portal hypertension were analysed(retrospectively).Results The 11 cases presented with gastric varices,splenomegaly,and pancreatic disease,but liver was normal.All cases underwent surgery,including splenectomy in 9 cases,splenectomy and distal pancreatectomy in 1 case,and other operation in 1 case.No serious complication was found postoperatively.Ten cases were followed up,no re-bleeding occurred postoperatively.Conclusions Regional pancreatic portal hypertension can be diagnosed correctly preoperatively and treated effectively.

Objective To explore the technique of T-tube replacement after choledochoscopy.Methods Choledochoscopy was performed in 256 cases,replacement of T-tube was conducted by direct insertion technique in 85 cases(Group A),and by a wire-guide technique in 171 cases(Group B).Results Three cases of T-tube replacement were unsuccessful in group A,in one case of which,the T-tube was misguided into the bowel and the patient recovered after conservative treatment following the withdrawal of T-tube.In group B,all the T-tube replacements were conducted successfully with the wire-guide technique.Conclusions Replacement of T-tube is facilitated by the wire-guide technique.

Objective To assess the effect of intravenous infusion of octreotide in prevention of pancreatic fistula after pancreaticoduodenectomy. Methods The clinical data of 74 cases of pancreaticoduodenectomy performed from January 1996 to July 2003 were retrospectively reviewed. These included 36 cases in control group in which octreotide was not adminstered,and 38 cases in octreotide group in which octreotide was administered by intravenous infusion of 0.5?g/( kg?h) for 12 hours per day from the operative day to postoperative day 7. The study parameters included clinical manifestation,drainage from peritioned cavity and the amount of drainage of pancreatic fluid. Results The drainage of pancreatic fluid at postoperative day 1,3,5 the in octreotide group was significantly less than those in the control group,the average hospital stay and the incidence of pancreatic fistula were significantly lower than those in the control group,and the drainage of pancreatic fluid was significantly increased after the withdrawal of octreotide in the octreotide group. Conclusions Intravenous infusion of octreotide can significantly lower the incidence of pancreatic fistula after pancreaticoduodenectomy.