BACKGROUND:At present, liver transplantation is the best method to treat end-stage liver disease. UW solution is recognized as the best liver preservation solution, but it is expensive. Moreover, the extracel ular fluid of high K+condition is inconsistent with human physiology. Because transient hyperkalemia of UW solution often causes cardiac arrest, research and development of the new liver preservation solution already brook no delay. OBJECTIVE:To study the protective effect of self-designed KYL solution on ischemia reperfusion injury in macaque donor liver. METHODS:A total of eight recipient macaques and eight donor macaques were selected in this study. Each group contained KYL solution group (n=4) and UW solution group (n=4). Donor liver was perfused and cryopreserved for 4 hours and subjected to al ogenic orthotopic liver transplantation. At 30 minutes and 6 hours after transplantation, bile production was recorded. Blood was obtained and used to detect concentrations of aspartate aminotransferase, alanine aminotransferase, nitric oxide, endothelin-1 and tumor necrosis factor-α. Liver tissue was col ected and detected under the light microscope. RESULTS AND CONCLUSION:Bile secretion was found in both groups. Bile secretion production increased as time went on (P<0.05). At 30 minutes and 6 hours after donor liver reperfusion, serum aspartate aminotransferase and alanine aminotransferase concentrations were lower in the KYL solution group than in the UW solution group (P<0.05). No significant difference was found in levels of serum nitric oxide, endothelin 1 and tumor necrosis factor alpha between the two groups (P>0.05). Under light microscope, morphological observation of liver tissue revealed that cel ular edema was evident in the UW solution group than in the KYL solution group. Results suggest that the effect of KYL solution on preventing ischemia/reperfusion injury was identical to the UW solution, and partial effect was better than UW solution.

Objective To explore the postoperative clinical complications of colorectal cancer surgery and their influencing factors. Methods Twenty-eight patients who received colorectal cancer surgery in our hospital from January 2010 to March 2015 were selected as the study subjects and analyzed. The patients' clinical symptoms, surgical methods, relevant complications and postoperative pathological results were explored. Results Of the 28 patients with colorectal cancer, postoperative complications occurred in 17 patients(60 . 71%), including 4 patients with stoma complication, 5 patients with anastomotic fistula and 8 patients with incision infection, and no death occurred. The main factors leading to postoperative complications included age, with preoperative diseases and serum albumin indicators. Conclusion The postoperative complications of colorectal cancer surgery have various types and high incidences, so preoperative prevention and postoperative nursing intervention are of important significance to reducing the incidence of complications and improving the quality of life of patients.