Based on the experience of Fuzhou General Hospital of Nanjing Area Command in turning itself into a digitalized hospital in recent years, the paper expounds the role of the information system in hospital construction. It points out that reinforcing information system construction is conducive to enhancing modern management standards of the hospital. It argues that management is the key to guaranteeing sound hospital information system construction and proposes some principles that must be followed in the process, viz. people oriented, stratagem based, practice guided and maximumglobal benefits driven.

Objective To observe the changes of autonomic nervous function in elderly patients with coronary heart disease (CHD) accompanying anxiety or depression, and to explore their clinical significance. Methods The 85 elderly inpatients with CHD, diagnosed by selective coronary angiography, were divided into anxiety group (32 cases), depression group (28 cases) and control group (simple CHD without anxiety or depression, 25 cases). The heart rate variability (HRV) was analyzed according to electrocardiograph detected by dynamic cardiograms. Results Compared with the controls, the standard deviation of normal to normal intervals (SDNN), the rate mean square of the differences of successive RR intervals (rMSSD), the percentage of RR intervals differing ＞ 50 ms (PNN50) and the high frequency (HF) decreased markedly in patients with CHD accompanying anxiety or depression, and the low frequency (LF) increased significantly in anxiety group than in control group [(348. 2 ± 70. 6) Hz vs. (295.4+70.0) Hz, t=2.78,P＜0.05], while the HF decreased significantly [(65. 5±14. 4) Hz vs. (77.9± 13. 7) Hz, t=3.16,P＜0. 05]. There were no significant differences between the anxiety group and depression group in the corresponding parameters. Conclusions The injury of vagus nerve function, also autonomic nerve system dysfunction are more seriously in patients with CHD accompanying anxiety or depression than with simple CHD. Actively treating patients with CHD accompanying anxiety or depression may improve their prognosis.

Objective To investigate clinical feature, diagnosis and treatment of tuberculosis infection in renal transplant patients. Methods To analyze clinical data of 13 patients suffering from tuberculosis infection after renal transplantation retrospectively. Results Twelve patients got lung tuberculosis while only one lymphoid tuberculosis. They were unequivocally diagnosed as tuberculosis by radiological plain film, searching acid-fast bacilli in sputum repeatedly, detecting DNA of Bacillus tuberculosis by PCR and biopsy, 4 of whom had mixed infection in lung. Eleven patients recovered after standard antituberculosis therapy, but 2 died. Hepatic function lesion was main adverse reaction in treatment, but it could get normal after adjustment of immunodepressant. Conclusion Tuberculosis incidence rate in renal transplant patients increased obviously. Standard antituberculosis therapy is effective, but immunodepressant should be adjusted in time according to the change of hepatic function and renal function.

Data warehouse of Fuzhou General Hospital as the example, the basic conception and requirements of data warehouse are introduced in this paper. The design and construction of data warehouse are described from the aspects of subject determination, data preparation, model building, model evaluation and interpretation, and model application and consolidation. The main function of the data warehouse of Fuzhou General Hospital is also mentioned.

Objective To investigate the periodic variety at the germ form, quantity, flagellar expression and activity of breath enzyme etc during the swarming motility of Proteus mirabilis (PM). Methods The 2, 3, 5-tetraphenyltetrazolium chloride (TTC), as indictor of breath enzyme, was added to the culture medium. Electronic microscope was adopted to observe the germ form and flagellar. Quantity of PM was measured by turbidimetry. Results During the PM growth and migration at LB medium, the germ quantity reduced and form changed from short and small to long and thin, flagellar got more and breath enzyme turned into inactive. Conclusion At the LB medium, PM in growth process appeared varieties in length of germ body, flagellar quantity and germs density, etc. PM in solid medium appeared wave motility, resulting from many factors including the environment, the signal transduction in cells and the density of germ.

A digitized hospital is one with network management as its basic mode, information as the primary driving force of its development, information technology as a prop to enhance its technological strength, information culture as a way to change the ways of peoples education and work and their ideological concepts, and construction of information systems as a new growth point of its advancement. While construction of digitized hospitals is a natural trend of historical development and is presently viable, construction of information systems in domestic hospitals must be based on Chinas realities so as to build digitized hospitals with Chinese characteristics. In light of their hospitals experience in building itself into a digitized hospital, the authors point out that it is necessary to formulate in the first place an overall objective in view of the requirements of digitized hospitals and then proceed step by step according to plan.

The authors sum up the experience of their hospital in the construction of the information system, pointing out that the key to success in this aspect lies in the clarification of objectives and the formulation of a master plan. Then they give a further account of ways for doing a good job of the master plan and its implementation from the perspectives of the software, hardware, and cultivation of talents.

Citing the IT development of the General Hospital of Nanjing Military Region at Fuzhou as an example, the authors point out that emphasizing the role of the people and doing a good job of talent planning and cultivation is the key to the IT development of a hospital. They argue that a hospital must have leaders and managers that stress the IT development of the hospital; it must have a team of people with high IT expertise; it must have a large number of staff very familiar with the operation of the computer; and it must be able to integrate its human resources and give play to the overall efficiency.

Objective To investigate the mechanism of renal damage due to rupture of atheroselerotic plaque of renal artery in apolipoprotein E (ApoE) knock-out mice. Methods The model for atherosclerotie renal artery stenosis (ARAS) was established by using ApoE knockout mice. The model mice with renal artery stenosis <50% were divided into the plaque rupture group and the non-plaque rupture group. Wild-type C57BL/6J mice were used as the control group. All the mice were raised under the same conditions. The renal arteries and kidneys were collected for the following analysis. Nuclear factor-kappa-Bp65 (NF-kBp65), intercellular adhesion molecule 1 (ICAM-1) and P-selectin (P-sel) were determined by Western blotting. The expression of interleukin 6 (IL-6) mRNA was detected by RT-PCR. Immunohistochemistry was performed by using serial sections to detect F4/80-related macrophages. Urine n-acetyl-β-d-glucosaminidase (NAG) activity was determined by direct enzyme-substrate coloration. Results In comparison with the nonplaque rupture group and the control group, the expression of NF-kBp65 protein in the blood, renal artery and kidney increased significantly in the plaque rupture group (P<0.05). The expression of F4/80, ICAM-1, P-sel, and IL-6 mRNA were increased significantly in the plaque rupture group (P<0.05), as compared with the non-plaque rupture group and the control group. The Ser and the activity of urine NAG in the plaque rupture group were higher than those in the non-plaque rapture group. The expression of NF-KBp65 protein differed insignificantly between the control group and the non-plaque rupture group (P>O.05). The group differences in the expression of F4/80, ICAM-1, P-sel, and IL-6 mRNA were similar to those in the expression of NF-KBp65 protein. The group differences in the activity of urine NAG and the Scr were similar to those in the expression of NF-kBp65 protein. Conclusion Rupture of atherosclerotic plaque of renal artery causes renal pathology change and renal function damage, which is mediated by inflammation.

Objective To explore the therapeutic mechanisms of nitric oxide donor (SIN 1) in ischemic acute renal failure (IARF). Methods The effects of SIN 1 on intercellular adhesion molecule 1 (ICAM 1) expression and inflammatory cell infiltration in rat kidney after ischemia/reperfusion (I/R) injury were examined using ICAM 1, ?2 integrin polyclonal antibody, and immunohistochemistry. The renal functions were measured simultaneously. Results Progressive increased expression of ICAM 1 was found in kidneys, especially in vasa recta, after IR injury. ?2 integrin positive cells increased simultaneously in the outer medulla. The two indexes reached the peak values at 24 h after I/R injury. SIN 1 infusion at the beginning of reperfusion could remarkably inhibit the enhanced ICAM 1 expression, reduce the local infiltration of inflammatory cells, and ameliorate the renal functions. Conclusion NO donor can inhibit the renal expression of ICAM 1 and the infiltration of leukocytes after ischemia reperfusion injury, which may play an important role in the treatment of ischemic acute renal failure.