It is a clinically tough problem to repair compound tissue d efects of limbs. Application of microsurgical technique with autologous pedicel or free tissue grafts has saved numerous invalid limbs with tissue defects, and is still an essential method to restore compound tissue defects of limbs and res love effectively many difficult problems, such as larger solf tissue defects,seg mental bone defects, bone-skin compound defect, and etc. Microsurgical repair i n emergency has special value in treating compound tissue defects of hand. Altho ugh the resource of autologous tissue graft as donator is limited, tissue engine ering and gene technology hold the promise of revolutionary advances in repairin g compound tissue defects of limbs. Because of the achievements made in the fiel ds of trauma repair and tissue regeneration, both structure and function will be hopefully restored.

Objective To investigate the mental health status of students with foreign nursing spe-cialty and analyze its relationship with stress, coping style and perceived social support. Method The cluster sampling was conducted between students with foreign nursing specialty. The Perceived Social Support Scale (PSSS), Symptom Check List-90 (SCL-90), and self-designed demographic questionnaires including demographic information questionnaire, College Students Stress Scale and Coping Style Questionnaire were employed. Results Students with foreign nursing specialty obtained significantly higher scores in all factors of SCL-90 when compared to the national youth norm,and obtained significantly higher scores in factors of somatization, obsession, anxiety, fear and psychotic diseases when compared to the norm of college students. The multifactor analysis of mental health status in students with foreign nursing specialty showed that soma-tization factors contained personal stress, seeking help, family supports and other supports;obsession factors contained personal stress, negative life events, academic stress and solving problem;interpersonal sensitivity factors contained personal stress, academic stress, solving problem, self-blame, fantasy and retreat; depres-sion factors contained personal stress, academic stress, solving problem, self-blame and other supports;anxiety factors contained personal stress, academic stress, fantasy, self-blame, family supports and other supports; hostility factors contained personal stress, seeking help, retreat, fantasy and other supports; fear factors contained personal stress, academic stress, seeking help, retreat and fantasy; crankiness factors con-tained personal stress, academic stress, solving problem, retreat, self-blame, family supports and friend sup-ports; factors of psychotic diseases contained personal stress, academic stress, solving problem, self-blame and friend supports;and factors of other symptoms contained personal stress, negative life events, academic stress, retreat, self-blame, family supports, friend supports and other supports. Conclusion The mental health status of students with foreign nursing specialty was inferior to the norms of national youths and col-lege students. It was negatively correlated with stress, active coping style, friend supports and other supports;while positively correlated with passive coping style (except escape) and family supports. Therefore, mental health education toward students with foreign nursing specialty should be strengthened in order to reduce their stress, improve their coping style, enhance their social supports, and finally promote their mental and physical development.

Objective To observe the effects of methionine enkephalin (M-Enk) on migration of macrophages from mice with impaired liver and its immunomodulatory mechanisms. MethodsLiver of mice was impaired by feeding CCl4 and macrophage migration inhibitory factor (MMIF) was produced by Con A-stimulated spleen lympho- cytes. Inhibition of macrophage migration was measured in reaction system by adding M-Enk. Results Migration of macrophages in both liver-impaired and control group were suppressed by MMIF, but the suppression might be re- versed by adding 1 μmol/L M-Enk (P＜0. 05). M-Enk could significantly inhibit in vitro both of the combination of MMIF with macrophages and production of MMIF from lymphocytes (P＜0. 01). Macrophages from liver-imparied group showed a higher sensitivity compared to the control group (P＜0. 05). ConclusionThe study suggests that opi- oid peptieds play an important role in the modulation of the immune response under stress as liver impairment.

Objective:To explore the risk factors of deep vein thrombosis (DVT) of the lower extremity in patients with breast cancer after surgery.Methods:A total of 95 female patients (the experimental group) with DVT of the lower extremity after breast cancer surgery in Shanxi Provincial Cancer Hospital from May 2016 to May 2019 were retrospectively analyzed, and 85 female breast cancer patients without DVT of the lower extremity after surgery from January 2019 to May 2019 were treated as the control group. The general information and plasma total cholesterol (TC), triglyceride (TG), D-dimer (D-D) levels were compared between the two groups, and the risk factors for DVT of the lower extremity in patients with breast cancer after surgery were explored.Results:The body weight [(69.05±6.49) kg vs. (61.75±6.62) kg], body mass index (BMI) [(29.89±1.78) kg/m 2 vs. (24.23±1.33) kg/m 2] and the age [(51.57±5.93) years old vs. (45.44±5.21) years old] in the experimental group were higher than those in the control group, and the differences were statistically significant (all P < 0.01). The TC level in the experimental group was slightly higher than that in the control group, and the difference was not statistically significant ( P > 0.05); the TG level in the experimental group was higher than that in the control group, and the difference was statistically significant ( P < 0.01); the D-D level of the experimental group at 10 d after operation was higher than that of the control group, and the difference was statistically significant ( P < 0.01). Logistic regression analysis showed that body weight > 66.25 kg ( OR = 1.507, 95% CI 1.101-2.122, P = 0.021), BMI > 25.43 kg/m 2 ( OR = 1.518, 95% CI 1.067-2.123, P = 0.017), TG≥1.8 mmol/L ( OR = 1.324, 95% CI 1.077-2.139, P = 0.045), postoperative D-D > 5.0 mg/L ( OR = 1.525, 95% CI1.110-2.231, P = 0.027), and surgery duration ≥ 2 h ( OR = 1.470, 95% CI 1.017-2.122, P = 0.033) were independent influencing factors of DVT in breast cancer patients. Conclusions:Breast cancer patients are prone to DVT of the lower extremity after operation. For patients with large body weight, high BMI, high blood lipids, high D-D and the operation duration ≥ 2 h, the postoperative prevention for DVT should be carried out early. Once there is a condition of lower extremity swelling, early treatment should be given.

Quercetin is a kind of typical flavonoid, mainly found in various vegetables, fruits and Chinese herbs that are consumed daily, with the functions of anti-oxidation, anti-tumor, prevention and treatment of cardiovascular and cerebrovascular diseases. Quercetin is a natural compound with defined anti-tumor activity. Due to its low bioavailability and poor water solubility, quercetin has limitations in clinical application. The quercetin derivatives with good solubility, high bioavailability, metabolic stability, and low toxicity have been obtained through modification of quercetin structure. In recent years, a large number of quercetin ethers, esters, complexes, C-4 carbonyloxy substituted derivatives, A,B-ring modified compounds and other derivatives have been synthesized and tested for in vitro anticancer activity. The quercetin derivatives with anti-tumor activity synthesized in the last 5 years were reviewed in this paper.
Biological Availability ; Humans ; Neoplasms ; Oxidation-Reduction ; Quercetin ; Solubility