BACKGROUND:Creep is a visco-elastic biological material form of solid performance.It is necessary to understand the creep mechanical properties of middle cerebral artery in prevention and treatment of cerebral arteriosclerosis and cerebral hemorrhage.OBJECTIVE:To compare the creep rheological properties of middle cerebral artery between the normal and atherosclerotic animal model,to identify the effects of atherosclerosis on the creep properties of middle cerebral artery.METHODS:Male SD rats were randomly divided into 2 groups,in the model group,rats were injected vitamin D3+nicotine+ high-fat diet fed to prepare atherosclerosis models;in the control group,rats were fed with normal diet.Rats were killed at 4 weeks and the middle cerebral artery specimens were obtained.The creep experiments were performed with electron Shimadzu universal testing machine The stress rate was 0.01 Mpa/s,with 7 200 s experimental time.A total of 1 00 numbers were collected and analyzed using one linear regression analysis.The creep curve,as well as the variation of strain and time was recorded.RESULTS AND CONCLUSION:The middle cerebral artery creep changed faster at the initial 600 s in the normal and atherosclerotic rats,and then slowly decreased.The creep of normal rats were greater than that of the atherosclerotic artery specimens at the 7 200 s(50.38%,48.26%,P＜0.05).The results demonstrated that the middle cerebral artery have different mechanical properties of creep in normal and atherosclerotic rats.The creep curve is changed in an exponential relationship.and the atherosclerosis has certain effect on the creep characteristics of middle cerebral artery.

Objective To optimize the indicator system of the scientific research influence of the tertiary hospitals in China for future use.Methods 200 tertiary hospitals was randomly selected in China and the indicator data were collected.Statistics methodologies including coefficient of variation,coefficient of correlation and principal component analysis were adopted to screen the indictors.Results 3 indicators including the number of researchers,the number of drug clinical trial institution and the cited frequency of the Chinese papers were removed in the new indicator system.There was high correlation between the modified indicator system and the primary one.Conclusions The optimized indictor system in our study is scientific and simple.It can be used for evaluating the scientific research influence of the tertiary hospitals in China.

Objective To apply the combination evaluation model in the comprehensive evaluation of sci-tech influence of hospitals in China.Method 42 Grade-Ⅲll hospitals were selected and evaluated by analytic hierarchy process (AHP),principal components analysis and entropy method.Kendall's coefficient of concordance (W) was applied to check the coherence of the evaluation results from the three methods above.Average method,Borda method,Copeland method and fuzzy Borda method were used for combining the single evaluation result.Spearman rank correlation was then used for testing whether the combination evaluation results matched the single evaluation result.Result Kendall's W correlation test showed consistency among three single evaluation results.A strong correlation between each combination evaluation result and the single evaluation result was observed by Spearman rank correlation analysis.The average method was chosen as the best method based on the Spearman rank correlation coefficient.Conclusion The study confirmed that the combination evaluation method can be applied in evaluating sci-tech influence of hospitals in China.

Objective To investigate the regulating effects and mechanism of Laminaria japonica (L.japonica) on serum lipid of hyperlipidemia rats.Methods Forty healthy female Wistar rats were used to establish hyperlipidemia models by feeding fat-rich forage,and the powder of L.japonica was applied as a supplement in forage for test groups.The levels of serum lipid including the triglyceride(TG),total cholesterol(TC),low-density lipoprotein (LDL),high-density lipoprotein(HDL) and the activities of lipoproteinesterase(LPL) and hepatic lipase(HL) were detected by biochemical assay.Results The levels of serum TG and TC in test group decreased significantly than those in pre-treated and model group (P

Data Envelopment Analysis (DEA) method is used to evaluate the efficiency of 41 tertiary hospitals in 2015 in Beijing.The possible causes of non-DEA effective hospitals are analyzed,and the direction and measures of non-DEA effective hospitals to promote scientific research efficiency are put forward.

Intracranial stentosis is one of the important causes of ischemic stroke. In recently years, with the continuously development of endovascular intervention, angioplasty and stenting have become effective treatment options for intracranial stenosis. However, the indications, technical points, complications and prognosis of this treatment remain to be investigated and explored.

Objective To study the relationship between infection and hypokalemic paralysis and its clinical features.Methods A systemic analysis was made on the infection courses,clinical manifestations, serum levels of potassium and creatine phosphokinase,the results of electrophysiological and virological examinations in present 34 patients and 115 cases reported in literature with hypokalemic paralysis.Results There were differences in the clinical manifestations and denominations among the present and reported cases. No definite evidences for virus infections were found among patients who were characterized by acute flaccid paralysis accompanied with hypokalemia in the infection curses. The prognosis of the disorder was better after the patients were given potassium, and most of them didn't recur.Conclusion No enough evidences showed that this disorder was an independent disease.It should be named as "concomitant infectious hypokalemic paralysis" appropriately. It was probably a syndrome accompanied by infection on the base of hereditary susceptibility.

Transarterial chemoembolization (TACE) is the standard treatment of unresectable hepatocellular carcinoma (HCC).However,high incidence of metastasis following TACE has much negative influence on patient survival.In this article,we reviewed negative influence of TACE on biological behavior of residual HCC cells to provide evidence for further application of TACE.

Aim To explore the effect of picrodideⅡ on the expressions of Caspase-3 and poly ADP-ribose polymerase (PARP) in brain tissue following cerebral ischemic reperfusion injury in rats.Methods The middle cerebral artery occlusion reperfusion models were established with intraluminal thread methods in rats. PicrodideⅡ (10 mg·kg~(-1)) and salvianic acid A sodium (10 mg·kg~(-1)) were injected from tail vein for treatment. The neurological function was evaluated with Bederson's test and the cerebral infarction volume was observed with tetrazolium chloride (TTC) staining.The brain structure was observed by hematoxylin-eosin (HE) staining and the apoptosis was counted by TUNEL immunofluorescence assay. The expressions of Caspase-3 and PARP were detected with immunohistochemical and enzyme linked immunosorbent assay.Results After ischemia 2 h and reperfusion 22 h, the rats showed neurological function deficit and cerebral infarction in ischemic hemisphere. The expressions of Caspase-3 and PARP and the number of apoptotic cells in brain tissue increased compared with those in the sham operative group (P <0.05). In picroside and salvianic acid A sodium groups, the Bederson's scores and cerebral infarction volume, the expressions of Caspase-3 and PARP and the number of apoptosis cells were lower than those in the negative control group (P <0.05). While there was no significant difference in five indexes metioned above between picroside group and salvianic acid A sodium group (P >0.05).Conclusion PicrosideⅡ might reduce the expressions of Caspase-3 and PARP to inhibit the neuronal apoptosis induced by cerebral ischemia reperfusion injury and improve the neurological function of rats.