This article reviewed the digestive system characteristics,enteral nutrition style,milk choice,the starting time of enteral nutrition,the velocity of milk volume increased and the ideal growth velocity of very low birth weight infants.The aim was to investigate the effect of the different starting time of enteral nutrition on their digestive function and the growth velocity,in order to find the suitable starting time of enteral nutrition,providing the basis for clinical enteral nutrition program of very low birth weight infant.

Multidimensional features ( life cycle features, universal acceptability, authority, innovation and inter-disciplinarity) of frontier knowledge and their measurement methods were determined according to the current scien-tific achievements in order to help scientific workers and decision makers timely discover and accurately recognize frontier knowledge.The framework for studies on frontier knowledge discovery in medical field was proposed with its key problems explained in order to provide reference for its future study.

The paper analyzes the conditions of research on the current scientific literature text feature extraction methods,applies the TF-IDF method based on background knowledge in the medical text feature extraction,and conducts experimental comparison in four medical fields.The result indicates that this method can obviously improve the extraction effect when there are few vocabularies to be extracted,and is obviously superior to the IDF based TF-IDF method in the aspects of filtration of commonly-used words in the text set and identification of important feature words.

Objective To investigate the current status analysis the risk factors of medical adhesive related skin injury(MARSI) in neonates in NICU, in order to provide guidance in prevention and nursing of the skin injury. Methods Convenience sampling five NICU in Shenyang, prospective investigate the incidence of MARSI of neonates during the NICU stay, and analysis the incidence , injury type distribution and risk factors. Results The incidence of MARSI in neonates in NICU was 12.8%(53/413);the major injury type of MARSI was epidermal stripping(47.2%,25/53)and skin tear(35.8%,19/53) in mechanical injury;Logistic analysis showed that the independent risk factors of MARSI were the use of stomach tube, dehydrate skin and blue light therapy (χ2=5.953, 9.806 and 7.568, P<0.05). Conclusions MARSI is frequency interrupted in neonates during the NICU stay, correct selection of medical adhesive products, application of suitable paste and remove skills are helpful to reduce the incidence of MARSI in neonates during the NICU stay.

Objective To study the effects of overdose fluoride on blood lipid and hemorheology in rabbits and the protective effect of selenium. Methods Twenty male rabbits were divided into 4 groups: normal group,fluorine group(100 mg/L),selenium group(1 mg/L) and selenium (1 mg/L) plus fluorine (100 mg/L) group. After 6 months of treatment,whole blood rheology,blood serum TC,TG,HDL-C,LDL-C,SOD activity,GSH-Px activity,the content of MDA were determined. Results The whole blood rheology of rabbit in fluorine group was abnormal. Compared with the normal group,significant increase of blood serum TC,HDL-C,LDL-C was seen,decrease of SOD activity and GSH-Px activity and increase of the content of MDA in fluorine group was found. The results of selenium plus fluorine group was more close to the normal group compared with fluorine group. Conclusion Fluorosis can induce hemorheology and lipid metabolism disorder and decrease the capacity of antioxidase and moderate selenium intake may have some protective effect.

Intracranial stentosis is one of the important causes of ischemic stroke. In recently years, with the continuously development of endovascular intervention, angioplasty and stenting have become effective treatment options for intracranial stenosis. However, the indications, technical points, complications and prognosis of this treatment remain to be investigated and explored.

Endovascular interventional therapy can signifantly improve the clinical outcomes in patients with acute ischemic stroke.It has become the important therapeutic means and research focus for acute ischemic stroke.However,there are many factors affecting its efficacy.This article reviews the factors affecting the treatment effect of endovascular interventional therapy of acute ischemic stroke.

The paper puts forward the method for evaluation on the scientific influence of institution based on PageRank algorithm,configures the initial weight of each institution based on the problems of dividing equally the webpage weight number in the classical PageRank algorithm and cited frequency of the application chapter,constructs the network matrix cited by institution through the citation situation of medical SCI papers published by partial colleges and universities in 2015,respectively calculates the PageRank values of institution when self-citation is excluded or included,and conducts comparative analysis on the sequence of cited frequency indicators of the institution as well as H index.This method can be used to evaluate scientific influence of institution from two dimensions of quality and quantity.

Objective To study the protective effect of garlicin on radiation injury in mice. Methods Sixty mice were randomly divided into five groups:model control group, solvent control group and garlicin treatment groups[0.17, 0.33, 1.00 g/(kg?d)]. After treated by gavage for 20 consecutive days, the mice were exposed to 60Co-? irradiation for one time and the effect of the irradiation on the amounts of WBC in peripheral blood, the ratio of micronucleus cells in marrow, the content of DNA in marrow cells and the superoxide dismutase (SOD) activity were measured. Results Compared with the exposure group, garlicin increased the amounts of WBC, decreased the micronucleus frequency of marrow cells, increased the content of DNA in marrow cells and increased the SOD activity in mice. Conclusion Garlicin shows a protective effect on irradiation injury in mice.

Objective To investigate the influence of BK virus (BKV) activation in renal transplant recipients on the renal allograft function.Method Recipients receiving renal transplantation during 2010.3-2011.4 were sdected as objectives,the urine and peripheral blood samples of them were taken and real-time PCR assays were performed to detect BKV DNA at 0.5,1,3,6,9,and 12 months post-transplantation.Results Among 88 recipients,BKV viruria occurred in 27 (30.68％) patients,and sustained viruria occurred in 17 patients.37.0％ (10/27) of patients with BKV viruria developed inot BKV viremia,and sustained viremia occurred in 5 patients.The viral load in plasma was higher in patients with sustained viremia than in those with transient viremia (P＜0.05),and serum creatinine concentrations were higher when BK viremia occurred (P＜0.05).Conclusion Graft function was impaired among patients with BK viremia,and regularly monitoring BK virus in renal transplant recipients and clinical imervention based on plasma PCR results can prevent transplant kidney damage effectively.