Objective To study the relationship between the level of uric acid and oxidative stress in patients with chronic systolic heart failure (CSHF). Methods One hundred and nine hospitalized patients from June 2006 to March 2007 were selected. Based on organic heart disease and heart function, they were classified into two groups: CSHF group (81 cases) and control group (28 eases). According to NYHA heart function grade (Ⅱ, Ⅲ, Ⅳ), CSHF group was divided into three subgroups. The plasma concentration of GSH and GSSG was determined by using glutathione reduetase recycling method (GR-DTNB). Redox potential (Eh) was calculated using Nemst equation according to the concentration of reduced and oxidized glutathione. Results There was significant difference between control group and CSHF group in the level of uric acid [(310.54±99.92) μ mol/L vs (499.09±168.04) μ mol/L], P < 0.01. Uric acid had a negative correlation with LVEF (r=-0.247, P=0.026), and a positive correlation with LVED D (r=0.266, P=0.016). The concentration of uric acid had a negative correlation with GSH (r=-0.328,P=0.003), and a positive correlation with GSSG (r=0.244, P=0.028) and Eh (r=0.309, P=0.005). Conclusions The concentration of uric acid increases in CSHF patients and has a correlation with LVEF and LVEDD. It may be a supplementary marker to reflect heart function and the serious degree of CSHF. The concentration of uric acid has a negative correlation with GSH, and a positive correlation with GSSG and the value of Eh. It may be used as an indicator of oxidative stress concerning its metabolic pathway.

Computed tomography (CT) has been widely used in clinical diagnosis and made a great contribution to diagnosis by providing anatomical information with high-resolution.However,when metal implants exist in patients' body,reconstructed CT images are seriously interfered by metal artifacts.Metal artifacts are usually expressed as many dark and bright radiant streak artifacts which seriously reduce diagnosis reliability and bring errors into the calculation of dose distribution in radiotherapy.Therefore,the study of metal artifact reduction (MAR)is of great importance.This article reviews main methods on MAR developed in recent years,and give deep analysis on some of the methods.

Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the salvage pathway for the biosynthesis of nicotinamide adenine dinucleotide (NAD+) from nicotinamide. NAMPT is also a cytokine that inhibits the apoptosis of neutrophils under various inlfammatory stimuli, regulates various diseases and closely associates with the progression and prognosis of cancers. However, it is still not clear whether the cytokine-like function of NAMPT is interrelated with the biosynthesis enzyme activity of NAD+. This article aims to provide novel insights for inflammation and cancers treatment by reviewing the function of NAMPT in inflammation, carcinogenesis, cancer progression and its inhibitors, APO866/FK866.

Intensity-modulated radiation therapy is widely used in the treatment of tumor,and the dose distribution highly conforms to tumor target area in three-dimension.However,the factors such as complex beam,data error,algorithm error and machine error may cause large dose deviation in intensity-modulated radiation therapy,which may lead to unnecessary radiation accident.Therefore,standing on the patients' safety point of view,dose verification is usually performed before executing the treatment plan in order to ensure the safe implementation of the treatment plan and to avoid un-planned irradiation dose.Currently,there are many tools and methods of dose verification in clinic,including point dose verification tools like finger-shaped ionization chamber and thermoluminescence dosimeter;two-dimensional dose verification tools like Mapcheck,MatriXX and films;three-dimensional dose verification tools like ArcCHECK,Delta4 and the third-party software.These common clinical dose verification methods are reviewed in this paper.

Objective To study the detective sensitivity for position of multi-leave collimators ( MLC) using Delta-4. Methods First,the small positional deviation of MLC was simulated and measured using the linac (Varian,Trubeam) equipped with EPID.Then,two beam fields 2. 0 cm (x)×6. 0 cm (y), 7. 0 cm (x)×6. 0 cm (y) were designed,the x1 and x2 of MLC were expanded 0. 1 mm,0. 2 mm,0. 3 mm... 0. 9 mm and 1. 0 mm,2. 0...5. 0 mm to external simultaneously,different parameters of 3 mm/3%,2. 5 mm/2. 5%,2 mm/2%, 1. 5 mm/1. 5% and 1 mm/1% were used in Gamma analysis to analyze the difference between dose distribution detected by Delta-4 and original dose distribution with unexpanded MLC position derived from TPS. Results For 2. 0 cm ( x) × 6. 0 cm ( y) beam field, the pass rate of original dose distribution was 100%,and that decreased to 95. 5% when x1 ,x2 of MLC were expanded 0. 3 mm to external, and decreased to 89. 4% when expanded 0. 5 mm at 2. 5 mm/2. 5% statistical standards. For 7. 0 cm ( x) × 6. 0 cm ( y) beam field,the pass rate of original dose distribution was 96. 5%,and that decreased to less than 95% when x2,x2 of MLC were expanded 0. 3 mm to external,and passing rate was above 90% when MLC expanded less than 0. 5 mm at 1. 5 mm/1. 5% statistical standards. Conclusions For MLC' s positional deviation in decimillimeter level,raise standards of Gamma analysis properly may improve the capability of Delta-4 for detecting small positional deviation,but it won' t detect all the positional deviation of MLC in decimillimeter level. For different size of beam field,it is proposed to use different analytical standards for Delta-4.

More and more patients were treated by surgery with metal implants in clinic.Metal artifacts in CT images caused by metal implants brought challenges for postoperative evaluation and diagnosis of tumor.It also led to the possibility of missed diagnosis and misdiagnosis.In recent decades,the improved methods based on filtered-backprojection and iterative reconstruction algorithms have great progresses in reducing effects of metal artifacts.The actuality of techniques for metal artifact reduction were reviewed in this article.

Antiviral Agents ; therapeutic use ; Female ; Hepatitis B, Chronic ; drug therapy ; Humans ; Pregnancy ; Pregnancy Complications, Infectious ; drug therapy ; virology

With the improvement of the complexity of medical image synthesis and the demand for the accuracy of clinical radiotherapy, deep learning algorithm plays an increasingly important role in pseudo CT image synthesis and analysis. This paper classifies and analyzes the pseudo CT image synthesis technology based on deep learning method in terms of the types of image modes, and describes the ongoing application in radiotherapy.

Objective To observe the clinical efficacy of Tiaoxinyin treatment for diabetic cardiac autonomic neuropathy (DCAN);To evaluate its efficacy and safety.Methods One hundred patients of DCAN were randomly divided into experimental group (51 cases) and control group (49 cases). Both groups were given basic treatment of diet control and Metformin hydrochloride tablets orally taking. Patients in the experimental group were given Tiaoxinyin, while patients in the control group were treated with Mecobalamin tablets for 8 weeks. Changes and untoward effects in blood glucose, blood fat and heart rate variability were observed before and after treatment so as to compare the efficacy of two groups.Results The total effective rate of the experimental group was 82.35% (42/51) and the control group was 63.27% (31/49), with statistical significance between the two groups (P<0.01). The TCM scores of the two groups decreased after treatment, with statistical significance compared with those before treatment (P<0.01). The difference in TCM scores between the two groups was significance (P<0.05). The level of FBG and 2 h PG in the two groups declined (P<0.05). Heart rate variability had statistical significance compared with that before treatment (P<0.05), with statistical significance between the two groups (P<0.05). No obvious adverse reaction was found.Conclusion Tiaoxinyin is effective and safe in treating DCAN and can improve the heart rate variability indicators in patients.

Objective To study the conditions of callus induction with the roots of Aquilaria sinensis as explants. Methods Two sources of roots of Aquiliaria sinensis were selected as the explants. The effects of sterilization methods and the combination of different concentrations of phytohormones on callus induction were evaluated. Results When Aquiliaria sinensis root seedling was sterilized in 0.01mg/mL HgCl2 solution for 3 minutes, the sterilized effect was the best. The optimal callus induction medium was MS+0.1 mg/L 2,4-dichlorophenoxyacetic acid (2,4-D) +0.1 mg/L 6-benzylaminopurine (6-BA). Aseptic Aquiliaria sinensis root seedling cultivated in callus induction medium containing MS+1.0 mg/L naphthalene acetic acid ( NAA) +0.8 mg/L 6-BA achieved the highest callus induction rate. Conclusion Callus can be induced from two sources of Aquilaria sinensis roots. The induction rate of callus is lower when the explant root seedling is cultivated using 2,4-D alone as inducer, and is increased when used together with 6-BA.