Objective To compare the effects of early and conventional instillation of normuscle invasive bladder cancer after transurethral resection of bladder tumor.Methods The clinical data of 32 patients with normuscle invasive bladder cancer were retrospectively analyzed.They were divided into observation group (16 cases) and control group (16 cases).The clinical effects of the two groups were compared.Results The recurrence rate of two groups was significantly different (x2 =3.864,P ＜ 0.05).The average recurrence time of two groups was significantly different (t =6.389,P ＜ 0.05).The incidence rate of adverse reactions (x2 =0.369,P ＞ 0.05) and the incidence rate of toxic reactions(x2 =2.222,P ＞ 0.05) in two groups had no statistically significant differences.Conclusion It can lower the recurrence rate for early and conventional instillation of normuscle invasive bladder cancer after transurethral resection of bladder tumor and to delay the recurrence time,so it is widely applicable for clinic cure.

Tumor may generate from tumor stem cell and the microenvironment,and cancer stem cells are derived from the mutation of normal stem cells according to cancer stem cells hypothesis. Breast cancer stem cells are the first identified cancer stem cells in solid tumor. Breast cancer stem cells have been isolated successfully by many kinds of strategies, and their biological behaviors are gradually studied deeply. Self-renewal and differentiation of breast cancer stem cells are regulated by microenviroment and many signaling pathways. Therapy targeting breast cancer stem cells is gradually becoming the focus of tumor targeted therapy study.

Objective:To investigate the problems and countermeasures primary hospital radiology digital construction.Methods: The analysis of the current characteristics of the primary hospital radiology digital construction of its problems, propose solutions.Results:The primary hospital exists in the construction of digital radiology department layout as unscientific, CR and DR choose unreasonable, machine design flaws, PACS incompatible, system maintenance improper and operation of the medical staff is not standardized, require planning, the management, design, training, etc. to further improve.Conclusion: Radiology digital construction is the inevitable trend of development, only reasonable choice, scientific installation, meticulously maintained, proficient in primary hospital and give full play to its advantages.

Objective:To investigate the therapeutic medication for inpatients with cancer pain, and compare with the latest cancer treatment guidelines to improve the rational drug use. Methods:By a retrospective study, the medical record analysis for the inpatients with cancer from October to December in 2014 was performed, and the incidence of pain and the therapeutic medication were investiga-ted and the rationality of drug use was evaluated based on the latest cancer pain treatment guidelines. Results:The incidence of cancer pain was 25. 46% of 774 cases with new cancer, and 76. 58% of the patients with cancer pain were treated with analgesic drugs. In ac-cordance with the guidelines for the treatment scheme, there was no significant difference between the Opioid-Naive group ( guide group 1) and the Opioids-Tolerant group (guide group 2) in the combination therapy, while there was significant difference in the drug selec-tion and the time of administration. In the guide group 1 the proportion of oxywdone controlled-release tablets was signiticantly higher than that in the guide group 2, the ratio of taking the medicine on time in the guide group 1 was also higher than that in the guide group 2. Both groups showed difference from the guidelines in the pain assessment and titration and specific analgesic drug use. Conclusion:The findings indicate the difference between the pain treatment and the guidelines in therapeutic medication of cancer pain, and the propaganda and education of relevant knowledge should be strengthened to promote the treatment standard.

By discussing several measures such as perfecting the rules, formulating the quality standard of thesis and design, strengthening the guidance and monitoring, establishing the tutor team and the incentive mechanism etc., this article explores the methods to improve the quality of graduation thesis and design in university.

Objective:To investigate and explore the science management mode for high- value medical consumables in order to solve the problem of management deficiency in purchase and using of high-value medical consumables.Methods: To strengthen the management for high value consumables on 5 aspects: systematized institution, normalized processes, standardized operation, scientific evaluation and informationalized management.Results:The normalized, standardized and programmed management mode for high-value medical consumables has been established and improved throughout the whole process monitoring and management of total life cycle for the consumables. This research normalized the management for these consumables and formed a new science management mode.Conclusion: The exploration and implementation of new management method and path for medical high-value consumables can effectively improve the level of hospital material management, reduce management loopholes, decrease the cost of high-value consumables and increase work efficiency.

BACKGROUND:During total hip arthroplasty, it is difficult to accurately determine the exact orientation of the pelvis. Pelvic position is prone to change during treatment. After prosthesis implantation, angle deviation easily occurs. The surgeon is difficult to accurately determine the position and orientation of the prosthesis. OBJECTIVE:To investigate the effects of prosthesis position during total hip arthroplasty by using three-dimensional computer-aided technique, and to analyze the biomechanical properties of the prosthesis in total hip arthroplasty. METHODS:Data of ten patients undergoing total hip arthroplasty in theAffiliated Hospital of Binzhou Medical University from January to November 2015 were analyzed. SIEMENS/DEFINITION dual source CT was used to scan the skeleton of patients. CT data were colected as a basis for data in modeling. Slice thickness was 0.732 mm; resolution of the inner surface was 512 × 512. CT data were imported in three-dimensional reconstruction software of a computer. The models of femur and pelvis were established. According to the type of fracture, false models of total hip arthroplasty were established. Simultaneously, biomechanical prosthesis models were established. We determined research methods of prosthesis position by computer-aided techniques and analyzed biomechanical properties in total hip arthroplasty. RESULTS AND CONCLUSION:(1) The use of computer-aided technology couldclearly show the defect site. After determining the defect position using computer-aided techniques, prosthesis implantation and repair effect could be simulated in the software. (2) The computer-aided through technologycould accurately determine the vertical weight of the human. The acetabular center of rotation was used as the origin. A vertical paralel line was generated. The sagittal and coronal planes of the prosthesis could be set in new coordinates. (3) With the aid of computer, total hip prosthesis models were constrained and loaded, which lay the foundation for the operation through the model development. (4) The 10 patients achieved successful surgery. The position of prosthesis was correct in ninepatients, with a success rate of 90%. Patients were folowed up for 3 months. The patients did not have other complications. (5) These results suggest that computer-aided technology can do three-dimensional construction and analysis of the prosthesis, andcan construct the position of the prosthesis during total hip arthroplasty according to three-dimensional reconstruction of the digitized pelvis model so as to achieve precise positioning of surface hip prostheses, which can prevent excessive wear of the joint, make pelvis closer to the physiological state of the mechanical distribution, and achieve the desired effect.

Objective To investigate the role and feasibility of tumor necrosis factor(TNF) and/or interferon(IFN) in comprehensive treatment of tongue cancer in vitro and explore a new pathway about clinical treatment of tongue cancer . Methods The role of TNF and/or IFN in tongue cancer cell line (Tca 8113) growth and their effect on chemotherapy & radiotherapy of Tca8113 were detected by MTT-assay in vitro.Results ⑴There was a obvious volume-effect relationship in inhibitory effect of TNF or IFN on tongue cancer cell line; when TNF combind with IFN,their cytotoxity enhanced significantly than only TNF or IFN. ⑵TNF & IFN have enhanced the cytotoxities of low dose DDP,PLM and Taxol on Tca 8113 cell line.⑶TNF obviously enhanced the inhibition rate of radiotherapy(dosage:2～8Gy)on Tac 8113 cell line(P

Objective To Study the supplementary effect of internet communication technologydoctor-patient communication information system in the health education of patients in hand surgery department. Methods We divided 200 outpatients as well as 200 inpatients in hand surgery department into the control group and the test group with 100 cases in each group.We gave health education to the test group by sending short messages using doctor-patient communication information system. The control group received health education by routine method.The incidence rate of complications after operation in the two groups of inpatients and two groups of outpatients was compared. Results Statistical difference existed between the test group and the control group of inpatients and the test group and the control group of outpatients. Conclusions The application of internet communication technology of doctor-patient communication information system in the health education for patients in hand surgery department could effectivelydecrease the incidence rate of complications after operation.

“Three Yin and Three Yang” syndrome differentiation is a method and system generated from “Treatise on Febrile Diseases”. And it is a principle of syndrome differentiation and a criterion of treatment. Modern physicians give many descriptions on levels of “Three Yin and Three Yang” syndrome differentiation. There are a lot of different opinions on it, including “Yin and Yang”, ”three steps of Cluster analysis”, “one divided into two” combining with “one divided into three”, and “three steps of recognizing symptom, understanding disease and differentiating syndrome” theories. The author believes “Three Yin and Three Yang”syndrome differentiation consists of three levels:differentiating syndrome principle, differentiating syndrome category and differentiating syndrome type. Strengthening research on levels of syndrome differentiation helps to improve accuracy of syndrome differentiation, guide drug description and enhance clinical efficacy.