To explore new agents of gamma-aminobutyric acid (GABA) derivatives with more potent antiepileptic activity, a series of 4-(2-acetoxybenzoylamino) butyramide derivatives were designed and synthesized. All of the novel compounds (5a-51) were synthesized from GABA as starting material, and their structures were confirmed with IR, 1H NMR, EI-MS and elemental analysis. Preliminary pharmacological test in vitro showed that all target compounds displayed strong antiepileptic activities and were worth for further study. The structure-activity relationship of 4-(2-acetoxybenzoylamino) butyramide derivatives was also discussed preliminarily.

Objective To study the clinical application value of multi-slice spiral CT iliac venography.Methods The iliac venography with multi-slice spiral CT was performed in 50 cases.150 mgI/ml contrast medium at 2.5～3.0 ml/s was administered via the veins of dorsum of foot and the delayed time was 16～22 s,the images were reconstructed by several methods.The imaging quality and imaging characteristic of iliac vein disease were analyzed.Results Helical CT venography was performed successfully in all patients.Venography showed vein complete occlusion in 31 cases,vessel stenosis or filling defect in 9 cases,normally in 10 cases.The quality of images included:excellent 24%(12/50),good 60%(30/50),bad 16%(8/50),the collectivity was 84%(42/50).Conclusion The multi-slice spiral CT iliac venography is of certain clinical applied value.

Objective To explore the effect of dexmedetomidine on reviving period of general anesthesia in thyroid surgery patients.Methods A total of 80 patients undergoing thyroid surgery were selected as the subjects.These patients were randomly divided into two groups according to the random table method,40 cases in each group.The patients in the observation group were given intravenous drip of dexmedetomidine before anesthesia induction,and those in the control group were given intravenous drip of saline.After that,the two grouos were given the same method of anesthesia induction.Recovery of the patients,biochemical indicators [including systolic blood pressure (SBP),diastolic blood pressure (DBP),heart rate (HR),oxygen saturation (SpO2)],sedation and analgesia effects,and the incidence of adverse reactions in the two groups were compared.Results The eye opening recovery time,extubation time,spontaneous breathing time and time for orientation recovery in the observation group were (11.24 ± 1.31) min,(8.67 ± 0.78) min,(6.36 ± 0.43) min and (14.39 ± 1.56) min,respectively,which were shorter than those in the control group[(15.57 ± 2.63) min,(10.42 ± 1.12) min,(8.54 ± 0.65) min and (17.24 ± 2.33) min],the differences were statistically significant(t =9.320,8.109,17.691,6.428,all P ＜ 0.05).The SBP levels in the observation group at T1 and T2 were (124.69 ± 10.25) mmHg and (105.54 ± 12.87) mmHg,respectively,which were lower than those in the control group [(138.72 ± 13.84) mmHg and (135.25 ± 13.63) mmHg];DBP at T2 and T3 in the observation group were (71.53 ± 8.95) mmHg and (76.21 ± 7.34) mmHg,respectively,which were lower than those in the control group[(80.45 ± 10.75)mmHg and (80.29 ± 10.39)mmHg];HR at T2 in the observation group was (65.18 ± 5.75) times,which was lower than (79.84 ± 8.42) in the control group;and all the above differences were statistically significant (t =5.512,10.024,4.033,2.028,9.094,all P ＜ 0.05).The sedation score,pains score in the observation group were (2.89 ± 0.54) points,(1.42 ± 0.34) points,respectively,which were better than those in the control group[(1.02 ± 0.27) points and (3.71 ± 1.12) points],the differences were statistically significant(t =19.589,12.374,all P ＜ 0.05).The incidence rate of adverse reactions in the observation group was 7.50％,which was lower than 35.00％ in the control group,and the difference was statistically significant(x2 =9.038,P ＜ 0.05).Conclusion For patients given general anesthesia for thyroid surgery,pre-injection of dexmedetomidine can significantly reduce the stress response in patients during recovery period,and has no impact on the patients'awaking and extubation;besides,it has high safety,and can improve the patients'comfort during recovery,thus serve as an ideal drug for the control of restlessness;therefore,it is of significant value to be popularized in clinical application.

Objective:To explore the association between sleep duration, sleep quality and the prevalence of hypertension in the elderly aged 65 years and above.Methods:This study was conducted among the elderly in communities in Yiwu, China from April to July, 2019, and participants were recruited through physical examination in the hospital. Face-to-face interview was performed to obtain basic information. Sleep duration and sleep quality were evaluated by Pittsburgh Sleep Quality Index (PSQI). Associations between sleep duration, sleep quality and hypertension were evaluated by multivariate logistic regression analysis.Results:A total of 3 169 elderly persons, aged ≥65 years old, were included in the study. The overall prevalence of hypertension was 50.8%. The elderly with very poor sleep quality and short sleep duration accounted for 22.4% and 28.5%, respectively. After adjusting for demographic characteristics, socioeconomic status, lifestyle and health status, the OR of hypertension for the elderly with very poor sleep quality was 1.42 (95% CI: 1.12-1.80) compared with those with very good sleep quality. Compared with the elderly with sleep duration of 6-7 h a night, the OR of hypertension for those with sleep duration <6 h was 1.37 (95% CI: 1.15-1.65). As the sleep quality decreased, the risk for hypertension increased. An U-shaped association was found between sleep duration and risk of hypertension. Subgroup analyses showed that this association existed in both men and women, but only significant in the elderly aged <75 years. Conclusion:Poor sleep quality and short sleep duration were associated with risk for hypertension in the elderly.