1.Review and analysis of bilingual teaching for pathology
Jing SUN ; Xiaosong HU ; Xinlian LIU ; Yilun LIU
Chinese Journal of Medical Education Research 2006;0(07):-
Bilingual education is an important teaching reform in universities. Since 2006,our college has enacted the attempt for bilingual teaching of pathology,and accumulated abundant experiences during the conducting of the bilingual teaching of pathology.
2.The significance of renal tubular dysfunction in patients with refractoriness nephritic syndrome and interference study with Valsartan
Huanrong YANG ; Shufang CAI ; Xiaoqin LIU ; Aixia HAO ; Hongsheng ZHANG ; Yuxia QIN ; Xinlian ZHAO
Journal of Chinese Physician 2008;10(4):505-508
Objective To investigate the significance of renal tubular dysfunction in patients with refractoriness nephrotic syndrome(RNS)and the effect of interference treatment of Valsartan (VAL).Methods 79 cases of RNS and 68 healthy controls were recruited into the study. The 79 patients of RNS were divided randomly into the VAL group and the dipyridam group. On the basis of routine therapy, the VAL group was given VAL(80mg/d),and the dipyridam group taken dipyridam (150mg/d)orally for 12 weeks The glomerular tubular function(u-RBP,α1-MG,β2-MG,mAlb,NAG)were detected and the pathologic changes of tubukinterstitium were observed by using the methods of ELISA, biochemistry and scoring of the pathologic damage of tubulointerstitium before and after 12 weeks of VAL treatment in all of the cases. Results Urinary RBP,α1-MG,β2-MG,mAlb and NAG in all patients with RNS was evidently higher than that in healthy controls(P<0.01).Those had positive correlations with damages of tubulointerstitium(r=0.436,0.626,0.499,0.668,0.657,P<0.01).The interference outcome displayed that the excretion rates of urinary series of protein after oral use VAL in treatment group were markedly lower, while the control group had no distinct change. Conclusion There were various injury of tubulointerstitium and the disfiguration of renal tubular function in all cases with RNS. Damages of renal tubular function had positive correlation with tubulointemtitium injury and renal globular injury. Interference treatment with ARB in patients with RNS could improve renal tubular function, which is of great significance in delaying the progress of RNS.
3.Teaching practice and thinking of diagnostic pathology for postgraduates of pathology and patho-physiology
Juan LI ; Yihua CHEN ; Xinlian LIU ; Lushun ZHANG ; Jing SUN ; Cui JIA ; Shurong LI
Chinese Journal of Medical Education Research 2017;16(9):892-895
Some problems are arisen in teaching diagnostic pathology in our college for postgradu-ates of Pathology and Pathophysiology, the students' basic knowledge is weak, the cycle is short, the teaching team and resources are relatively insufficient. To promote the cultivation of graduate students, we should carry out the CBL teaching method, add the clinical practice and training, strengthen the teaching staff, and apply digital section and network platform.
4.Construction and application of medical morphology online picture examination system
Xia WANG ; Juan LI ; Xinzhi LI ; Xinlian LIU ; Lina WU ; Xiaosong HU
Chinese Journal of Medical Education Research 2020;19(12):E015-E015
At present, the experimental examination of medical morphology courses in most medical colleges and universities still adopt traditional specimen examination or PPT examination, and there are many disadvantages. This paper introduces how to build a system with B/S architecture based on the local area network, and how to set up an examination system to realize the functions of user management, online examination database updating, free examination paper formation, examination running and automatic marking. Through its application in our school in recent years, the medical morphology online picture exam system has effectively promoted the reform of the examination methods, the style of study and the effect of experimental teaching. However, there are still some problems, such as high investment cost and limited examination room.
5.The evaluation of SCI by TMS-MEP and its forensic significance.
Lei YANG ; Xing-Ben LIU ; Rong-Ting ZHU ; Xiao-Ming XU ; Chuan-Fei ZHENG ; Yu-Xin ZHOU
Journal of Forensic Medicine 2013;29(3):172-175
OBJECTIVE:
To find an objective and accurate examination for evaluation of spinal cord injury (SCI) in forensic clinical medicine.
METHODS:
The onset latency of cortex, peak latency of N1, central motor conduction time (CMCT) and wave width of the abductor pollicis brevis and the anterior tibialis were calculated by transcranial magnetic stimulation-motor evoked potential (TMS-MEP). The data of 68 patients suffered from SCI including 23 cervical levels and 45 thoracolumbar levels were collected and compared with that of 30 normal controls.
RESULTS:
In experimental group, when the muscle strength of the abductor pollicis brevis or the anterior tibialis decreased or disappeared, the onset latency of cortex, the peak latency of N1, and CMCT prolonged and the wave width broadened. And these indexes of grade 2 and 3 muscle strength in experimental group were higher than that in the control group (P < 0.05).
CONCLUSION
The TMS-MEP can determine directly and objectively the motor functional status of pyramidal tract of spinal cord in order to provide more accurate and objective evidences in forensic medicine.
Adolescent
;
Adult
;
Case-Control Studies
;
Evoked Potentials, Motor/physiology*
;
Female
;
Forensic Medicine/methods*
;
Humans
;
Male
;
Middle Aged
;
Monitoring, Physiologic
;
Motor Cortex/physiology*
;
Muscle, Skeletal/physiology*
;
Neural Conduction/physiology*
;
Reaction Time/physiology*
;
Spinal Cord Injuries/physiopathology*
;
Transcranial Magnetic Stimulation
;
Young Adult
6.Construction and application of medical morphology online picture examination system
Xia WANG ; Juan LI ; Xinzhi LI ; Xinlian LIU ; Lina WU ; Xiaosong HU
Chinese Journal of Medical Education Research 2022;21(2):176-178
At present, the experimental examination of medical morphology courses in most medical colleges and universities still adopt traditional specimen examination or PPT examination, and there are many disadvantages. This paper introduces how to build a system with B/S architecture based on the local area network, and how to set up an examination system to realize the functions of user management, online examination database updating, free examination paper formation, examination running and automatic marking. Through its application in Chengdu Medical College in recent years, the medical morphology online picture exam system has effectively promoted the reform of the examination methods, the style of study and the effect of experimental teaching. However, there are still some problems, such as high investment cost and limited examination room.
7.Construction and application of a case-based learning database of pathology for students in imaging specialty
Juan LI ; Shurong LI ; Lushun ZHANG ; Xinlian LIU ; Xiaobo WU
Chinese Journal of Medical Education Research 2020;19(5):543-546
To establish a case-based learning (CBL) database of Pathology for medical students in imaging specialty, which includes chief complaints and history of present illness, case characteristics, imaging findings, questions, surgical findings and discussion. Cases in the CBL database was obtained from newly resected specimen, which were combined with various imaging test results of patients before surgery. All the information of each case, including postoperative pathological diagnosis report, was collected to perfect the database. The database was used in the CBL teaching of pathology, which has stimulated students' learning initiative and enthusiasm, cultivated their logic thinking of imaging diagnosis and improved the teaching effect.
8.Application of copy number variation sequencing for prenatal diagnosis in women at an advanced maternal age.
Jing WANG ; Ling CHEN ; Cong ZHOU ; Li WANG ; Hanbing XIE ; Yuanyuan XIAO ; Hongmei ZHU ; Ting HU ; Zhu ZHANG ; Qian ZHU ; Xinlian CHEN ; Zhuying LIU ; Shanlin LIU ; He WANG ; Hongqian LIU
Chinese Journal of Medical Genetics 2019;36(6):533-537
OBJECTIVE:
To assess the value of copy number variation analysis based on next generation sequencing (CNV-seq) in prenatal diagnosis for women at advanced maternal age.
METHODS:
A prospective analysis was carried out for women who underwent amniocentesis at 18~36 weeks of gestation for fetal CNV-seq for advanced maternal age.
RESULTS:
For 1461 unrelated Chinese women with a singleton pregnancy, CNV-seq was performed for all samples successfully. The proportion of chromosomal abnormalities was 2.3% (34/1461), of which 44.12% were submicroscopic copy number variations (<5 Mb).
CONCLUSION
Pregnant women at an advanced maternal age should be informed for not only common trisomies but all pathogenic chromosomal aberrations. NGS was a sensitive and accurate approach for detecting CNVs.
Chromosome Aberrations
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Chromosome Disorders
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DNA Copy Number Variations
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Female
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Humans
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Maternal Age
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Pregnancy
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Prenatal Diagnosis
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Prospective Studies
9.Evaluation of the efficacy of cevimeline in improving the clinical symptoms of patients with primary Sjögren′s syndrome
WANG Shengming ; LI Fangfang ; WU Yao ; Yao Xinlian ; LIU Xin
Journal of Prevention and Treatment for Stomatological Diseases 2021;29(1):40-44
Objective:
To investigate the clinical efficacy of cevimeline as a pharmacotherapeutic approach to stimulating gland activity in improving the symptoms and signs of primary Sjögren syndrome (pSS).
Methods:
Sixty-three patients diagnosed with pSS who attended the Affiliated Huai'an Hospital of Xuzhou Medical University from January 2018 to September 2019 were included in this trial. They were randomly assigned to the therapeutic group and control group. All patients were recalled at baseline and after 2 weeks, 3 months and 6 months. Measurement of salivary and lacrimal flow as well as evaluation of subjective symptoms was performed at the follow-up.
Results:
Fifty-eight patients completed the trial and were included in the statistical analysis. There was a significant difference between the two groups in the measurement of salivary and lacrimal flow at the second week and third month (P < 0.05). Improvement in subjective symptoms of oral, ocular and gland was detected at the third month (P < 0.05). At the sixth month, compared with the control group, only the salivary gland symptom score of the treatment group was statistically significant (P < 0.05).
Conclusion
Cevimeline has good specificity and safety and can increase salivary and lacrimal flow and improve subjective symptoms of pSS in a short time.
10.Predictive value of ultrasound signs of the involvement of the cervix in the adverse pregnancy outcomes of placenta accreta spectrum
Jingjing XUE ; Li WANG ; Jingjing CUI ; Qingqing WU ; Jingjing WANG ; Xiaowei LIU ; Xinlian WANG ; Yang ZHAN
Chinese Journal of Ultrasonography 2022;31(2):135-139
Objective:To explore the the predictive value of ultrasound signs of the involvement of the cervix in the clinical grade diagnosis of placenta accreta spectrum(PAS) with placenta previa and adverse pregnancy outcomes.Methods:A retrospective analysis was performed on PAS patients with placenta previa diagnosed during delivery or by cesarean section in Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University from January 2018 to March 2021. According to the signs of cervical involvement on prenatal ultrasound, the patients were divided into cervical involvement group and cervical non-involvement group. Logistic analysis was performed on clinical data between the two groups. The clinical data, hysterectomy rate, intraoperative blood loss and clinical diagnosis were compared between the two groups.Results:There were 1 455 patients with PAS diagnosed by clinical diagnosis or placental pathology, of which 170 were with placenta previa, 24 with incomplete clinical data or non-standard ultrasound images, and the remaining 146 patients were included. In the cervical involvement group, all of 6 cases had placenta percreta. Of the 140 cases in the unaffected cervical group, 89 cases (63.6%) had placental accreta, 48 cases (34.3%) had placental increta, and 3 cases (2.1%) had placenta percreta. There were no significant differences of the age and uterine operation history between the two groups. There was significant difference in the number of cesarean sections between the two groups ( P<0.05). There were significant differences in intraoperative blood loss, hysterectomy rate and placenta accreta grade diagnosis between the two groups(χ 2/ Z=4.203, 11.165, 95.248, all P<0.05). Conclusions:The ultrasonographic signs of cervical involvement have a good predictive value for the pregnancy outcome of PAS.