Acute Kidney Injury ; chemically induced ; Humans ; Paraquat ; poisoning ; Rhabdomyolysis ; chemically induced

Objective To discuss clinical effect of bronchodilator treatment on patients with chronic obstruc-tive pulmonary disease.Methods According to the exclusion criteria,106 patients were selected and randomly divid-ed into two groups,the control group were given glucocorticoid therapy,the study group was given glucocorticoid +bronchodilator treatment;lung index,including forced expiratory volume in one second,forced vital capacity,and the percentage of forced expiratory volume in one second of forced vital capacity of the two groups were compared,and the patientˊs clinical curative effect was observed.Results The patients of the study group of three indicators:forced expiratory volume in one second,forced vital capacity,forced expiratory volume in one second of forced vital capacity percentage were (1.6 ±0.8)L,(3.4 ±0.4)L,(48.6 ±2.3)%,which were higher than those of the control group, the differences were statistically significant (P <0.05);The total effective rate of the study group was 96.3%,which was higher than 81.2% of the control group,the difference was statistically significant (P <0.05).Conclusion The clinical effect of glucocorticoid +bronchodilator on patients with chronic obstructive pulmonary disease is good,which can effectively improve patient forced expiratory volume in one second,forced vital capacity,forced expiratory volume in one second percentage of forced vital capacity,and can avoid illness development,significantly improve the treat-ment efficiency.

Objective To explore methods for hypertension intervention healthy promotion, improve villagers 'healthy consciousness and facilitate their behavior change in country. Methods Adopted "point to lead side and point combine with side" to develop community diagnosis and mobilization, establish system for measuring blood, organize villagers abstain from tobacco and supervise those who with hypertension in experimental village. Use self comparison to evaluate intervention effects. Results Understanding rate(full understanding means knowing all parts of the project ) about the clinical manifestation and harmful influence of hypertension have increased from 2.0% to 10.4% and 0.2% to 8.7% respectively just after intervening, but preventive knowledge level hasn't improved obviously between 2003(before intervening) and 2006(after intervening).Before 2003, There were no villagers have ever measured their blood pressure on their own, and the rate of medical workers who have measured blood pressure for patients on their own was 28.5%. But after 2006, the rate of villagers who know ought to measure blood pressure periodical was 97.6%, and among them, 83.0% have measured their blood pressure on their own. Medical workers who have measured blood pressure for patients increase to 80%~90%. Through medical institution launching a program named " measuring blood pressure for above 35 years free charge", 137 822 hypertensive were found in 3 years in 6 item country 256 health institutions of township and village levels. Among those 51 505 were found freshly. Conclusion We adopted a series of measures, which were take countryside government to be guidance, take village hospital to be technical support, take village hospital to be flat, take village committee to be support and take villagers prescript to be obligation. Through every intervention, we improved villagers' healthy consciousness and facilitated their behavior change. Trough" measuring blood pressure for above 35 years free of charge", it can make more hypertensive get diagnosis and therapy timely.

Objective To review the regulation of liver regeneration factors.Methods The literatures about liver regeneration related regulators in recent years were reviewed.Results With further advancement of researches on regulators of liver regeneration in recent years,there were more therapies for treatment of liver-related diseases.Regulators play important roles in the process of liver regeneration,as one of which,cell growth factor plays an essential role in liver cell proliferation,such as the proper expression of TNF-? and IL-6 promoting liver cell proliferation,HGF,TGF-?,EGF,ALR,FS,and others motivating liver cell proliferation,while TGF-? and IL-1 physically terminating liver cell proliferation.Conclusion By strengthening the studies on liver regeneration regulators,new methods may appear for treating liver-related diseases.

Objective:To determine whether mild hypothermia,isoflurane and propofol reduce gultamate release in rat hippocampus brain slices after hypoxia. Method: Brain slices preparations were separated and incubated from rat hippocampus. Glutamate released from rat brain slices during chemical anoxia(100?M KCN)were measured with a fluorescence assay,at 28℃,31℃ and 37℃ after anoxia and after administration of 1 MAC of isoflurane and 200 ?m propofol respectively. Result: Glutamate release was significantly reduced at 28℃ or 31℃ compare with that at 37℃ (P

Objective To observe the clinical efficacy of dendritic cell-cytokine-induced killer cell (DC-CIK) combined with interleukin (IL)-2 in treatment of renal cell carcinoma.Methods A total of 60 patients with renal cell carcinoma after radical nephrectomy were randomly divided into treatment group and control group.Thirty cases in treatment group were given DC-CIK cells combined with IL-2 treatment.Thirty cases in control group were treated with IL-2 treatment.The immune function,quality of life,survival rate and adverse reactions were analyzed in two groups.Results Compared with before treatment,the percentages of CD3+,CD4+,CD4+/CD8+ ratio and CD16+CD56+ increased and CD8+ decreased significantly in treatment group(P ＜ 0.05).In control group,there was no significant change before and after treatment in the percentages of CD3+,CD4+,CD4+/CD8+ ratio,CD16+ CD56+ and CD8+(P ＞ 0.05).Quality of life of 83.3％(25/30)patients in treatment group was improved,56.7％(17/30) patients in control group was improved,there was significant difference between two groups (P ＜ 0.05).The 1-year survival rate in treatment group and control group were 93.3％ (28/30),83.3％ (25/30),and the 1-year recurrence rate in two groups were 6.7％ (2/30)and 13.3％ (4/30),there were no significant difference between two groups (P ＞ 0.05).There were no significant statistically in the incidence of adverse reactions between two groups (P ＞ 0.05).Conclusion DC-CIK cells combined with IL-2 in treatment of renal cell carcinoma after radical nepbrectomy can improve patients' immune function and quality of life.

Objective To Discuss the influence of intrauterine environment to neonatal insulin sensitivity. Methods Two hundred and eight new borns were selected into our study and divided into 4 groups, they are full term adequate for gestational age(AGA) group(133 cases), full term small for gestational age(SGA) group(30 cases), preterm AGA group(87 cases) and preterm SGA group(30 cases). In the morning of the 3rd day after birth their serum glucose, insulin and lipid concentration were examined before milk, and the ratio of insulin to glucose were calculated. Statistical analysis was performed with the SPSS 9.0 software. Results The mean ratio of insulin to glucose are 1.243?0.703 in full term SGA group and 0.259?0.837 in full term AGA group, while in preterm SGA group and preterm AGA group the mean ratio of insulin to glucose are 1.190?0.683 and 0.497? 0.080, it shows that each SGA group has significantly higher insulin to glucose ratio than the AGA group( P

Objective To investigate the clinical efficacy of uterine artery embolization (UAE) for the treatment of cesarean scar pregnancy compared with gelatin sponge strip and gelatin sponge particles as an embolic agent.Methods A retrospective study was performed of 94 consecutive patients with a diagnosis of cesarean scar pregnancy, and they were divided into two groups randomly.The embolic agent in experimental group was gelatin sponge strip and gelatin sponge particles were used in control group.All the cases underwent curettage operation after UAE.The mean amount of bleeding loss during curettage operation, abdominal pain degree after UAE procedure, UAE costs and time of recovery to the normal level of blood β-human chorionic gonadotropin (β-HCG) were compared between two groups.Results The mean amount of bleeding loss during curettage operation and time of recovery to the normal level of blood β-HCG were no statistical differences compared with the two groups, but the abdominal pain degree after UAE procedure and UAE costs in experimental group were lower than in control group, there were significant statistical differences compared with the two groups.Conclusion Gelatin sponge strip as an embolic agent in the UAE procedure of cesarean scar pregnancy could reduce post-operative pain and the cost, which is worthy of clinical promotion.

Objective To investigate the insulin sensitivity in children born small for gestational age without catch-up growth.Methods We investigated 439 outpatients in pediatric department of the Third Hospital of Peking University with diagnosis of short stature from August 2008 to August 2016.Two groups were divided based on their diagnosis as born small for gestational age group(SGA)with 218 patients and idiopathic short stature group(ISS)with 221 patients.Fasting blood-glucose,fasting insulin,fasting insulin/fasting blood-glucose,islet beta-cell function(HOMA%),homeostasis model assessment-insulin resistance(HOMA-IR)were analyzed in two groups.Results Hierarchy based on age and sex in SGA and ISS.No significant difference was observed in preadolescent boys with fasting blood-glucose(4.7±0.6 vs 4.8±0.6,P=0.678),fasting insulin(5.1±4.0 vs 4.3±4.7,P=0.345),fasting insulin/fasting blood-glucose,HOMA%,HOMA-IR.No significant difference was observed in preadolescent girls with fasting blood-glucose(4.5±0.5 vs 4.6±0.5,P=0.828),fasting insulin(4.7±3.5 vs 4.5±3.3,P=0.603),fasting insulin/fasting blood-glucose,HOMA%,HOMA-IR.No significant difference was observed in adolescent boys with fasting insulin(5.9±4.3 vs 6.0±4.5,P=0.958),fasting blood-glucose(5.0±0.8 vs 4.9±0.5,P=0.176),fasting insulin/fasting blood-glucose,HOMA%,HOMA-IR.No significant difference was observed in adolescent girls with fasting blood-glucose(4.9±0.6 vs 4.8±0.4,P=0.141),fasting insulin(7.5±6.4 vs 7.4±8.6,P=0.448),fasting insulin/fasting blood-glucose,HOMA%,HOMA-IR.Conclusion The insulin sensitivity were in good condition in children born small for gestational age without catch-up growth.

3 d) was only 1 in each. Conclusions In prevention or treatment of NRDS with PS,prophylactive indome-(thacin) reduces the rate of PDA,pulmonary hemorrhage and early death in preterm infants.