Objective To investigate a mechanism protected radiation-induce injure for radiated guinea pigs'nasal mucosa treated with intranasal corticosteroids (fluticasone nasal cavity spray). Methods 50 health guinea pigs were divided into 2 groups randomly: the irradiated group (control group) with 25 guinea pigs and the administration group after irradiation (test group)with 25 guinea pigs. The nasal part of all guinea pigs were performed irradiation by the 6 MV X-ray with single 5 Gy, one time each week for three weeks. The guinea pigs of test group received intranasai eorticosteroids with one time every day and one spray each side nasal cavity on the second day after three weeks irradiation. Five guinea pigs in each group were saeritieed randomly at 1 week, 1 month, 2 months, 3 months and 4 months after irradiation, and the histopathologie changes were observed under optical microscope and electron microscope. At the same time, blood were drawn from the heart and the concentration of IL-1, IL-6 and TNF-α in serum were measured by ELISA. Results The early nasal mucosa inllammatory reaction of the test group was less than the control group. The coverage rate of cilia of the test group was much than that of the control group (72.9% vs 50.2%) at four months after irradiation. The atrophy of submucosal glandular organ was lessened and they displayed some extent secretory function. The concentration of IL-1 in serum was increased very much in the test group compared with the control group after irradiation and kept higher level in the first two months. After two months, it began to decrease;on four months, it still kept equivalency level with the control group. The concentration of IL-6 and TNF-α in serum were reduced all the while. Conclusions The intranasal eortieosteroids with fluticasene nasal cavity spray can reduce radiation-induced injury of guinea pigs' nasal mucosa. The concentration change of IL-I, IL-6 and TNF-α in serum may be one of mechanism protected radiation-induce injure of guinea pigs' nasal mueosa.

Objective To study the influence of cilostazol to aspirin resistance in patients with coronary heart disease.Methods A total of 165 patients with coronary heart disease were set apart two groups:group A:coronary heart disease,group B:coronary heart disease by 2-diabetes mellitus,Both group A and group B received 100 mg of aspirin daily for 7 days and no other antiplatelet agent.The blood samples were analyzed by platelet aggregation(PAG)test.Platelet aggregation using adenosine diphosphate(ADP)and arachidonic acid(AA).then two groups were randomized four groups:A1,A2,B1,B2 separately.both group A1 and B1received aspirin 100 mg qd continuely,group A2 and B2 added anther antiplatelet drug cilostazol 50 mg bid,redetected platelet aggregation after a week.compared PAG and AR using statistic methods.Results PAG and AR of group A is lower than group B(P0.05).The PAG and AR of group A2 was significantly lower than group A and group A1(P0.05),the PAG and AR of group B2 is significantly lower than group B and group B1(P

Preoperative qualitative diagnoses of 118 eases of renal tumour.made by B-mode ultrasound were analyzed.The final diagnoses were proven operatively and pathologically.The resultsshowed that by B-mode altrasound the detective rate was 92.2%,a correct qualitative diagnosis rate 49.1%,incorrect rate 18.1%and false positive rate 1.7%.Qualitatively unidentified turnouts accounted for 32.8%of all the cases.It is assumed that B-mode ultrasound can be used to make correct qualitative diagnosis only on certain tumours with typical image features.It is difficult for it to distinguish some tumours which have complicated displays.The accuracy of preoperative qualitative diagnosis could be raised by combining B-mode uhradound with other imaging technologicol examinations.

Objective: To study shame of college student through phenomenological method. Method: 147 college students (male 53, female 94, average age 20.2) were involved. Each subject was asked to describe his/her personal shame experience, which was rate on phenomenological dimensions. Experience of Shame Scales (ESS) was used either. Result: The finding from phenomenological rating was in accord with the theory of “self orientation". Students with stronger shame proneness showed tendency to attribute negative events to him/herself. Conclusion: Shame is an acutely painful experience that involves a marked self-focus (self oriented) emotion. Shame proneness tended to have stronger sense of worthlessness and powerlessness and have much more strategies of denying and escaping in hard situations.

Objective To understand the drug resistance characteristics of pseudomonas aeruginosa and to guide the selection of clinical antibacterial drugs .Methods The clinically isolated 335 strains of pseudomonas aeruginosa from the Xuzhou Municipal First People′s Hospital in 2013 were collected and performed the drug susceptibility test .The test results and data were analyzed by using the WHONET5 .6 software .Results Clinically isolated 335 strains of pseudomonas aeruginosa had different degrees of re‐sistance to 15 kinds of antibacterial drugs ,in which the sensitivities to piperacillin/tazobactam ,amikacin ,tobramycin ,ciprofloxacin , levofloxacin ,ceftazidine ,cefepime and gentamicin were higher ;the resistance rate to ampicillin/sulbactam ,ceftriaxone ,ampicillin and cefotaxime was up to above 97% .In the same patients with several times of this bacterial detection ,larger volatility existed in the susceptibility results of piperacillin/tazobactam ,ceftazidine ,cefepime ,imipenem and gentamicin .Meanwhile the drug resitance spectrum of Pseudomonas aeruginosa had a certain tendency .Conclusion Strengthening continuous etiology and drug resistance moni‐toring is in response to the occurrence of acute drug resistance and nosocomial infection spread ,meanwhile guides clinical treatment .

Objective To investigate association of IL-10 gene promoter polymorphisms with first episode schizophrenic and efficacy of risperidone.Methods 513 schizophrenic patients with first episode(patient group) and 627 health controls(control group)participated in this study.Genotyping for IL-10 gene label single nucleotide polymorphism(SNP) sites-592A/C (rs1800872),-1082A/G (rs1800896),-819T/C (rs1800871) were performed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP)genotyping technology.513 patients were administered orally risperidone for 8 weeks.Clinical efficacy were evaluated with PANSS.Results The frequences of rs1800896 genotypes (332:166:15,453:161:13 ; x2 =7.55,df=2,P=0.02) and alleles(830:196,1067:187; x2 =7.09,df=1,P=0.008,OR=1.35,95％ CI=1.08 ～ 1.68) showed significant differences between patient group and control group,however only allele differences showed statistical significance after Bonferroni correction (P=0.024).The frequencies of rs1800872and rs1800871 genotypes and alleles had no significant differences between patient group and control group(P＞0.05).There were no significant differences of haplotype frequences between patient group and control group (P＞ 0.05).There were no significant differences of genotypes (134:209:38,61:59:12;x2 =5.16,df=2,P=0.08;244:129:8,88:37:7;x2 =4.57,df=2,P=0.10; 188:158:35,54:64:14;x2=2.80,df=2,P=0.25) and alleles (477:285,181:83;x2 =3.03,df=1,P=0.08;617:145,213:51 ;x2 =0.01,df=1,P=0.92;534:228,172:92;x2 =2.22,df=1,P=0.14) frequences of rs1800872,rs1800896,rs 1800871 between effective group (381 cases) and invalid group (132 cases) of Risperidone efficacy (P＞ 0.05),while ATC haplotype frequences had significant difference between two groups(x2 =7.501,P=0.006,OR (95％ CI) =2.420(1.262-4.640)).Conclusion IL-10 gene rs1800896 polymorphism may be associated with susceptibility to schizophrenia.The clinical curative effect of risperidone in the treatment of schizophrenia is associated with ATC haplotype,ATC haplotype may be good predictors to the overall curative effect of risperidone.

During the period of establishing and perfecting socialist market economy in current situation,the professional morality of medical trade emerges much more new matters and problems and faces severe challenges.This article analyses the causes of these problems and difficulties on improving the professional morality of medical trade nowudays,and raises some strategies to solve these problems,such as reforming the medical system in-depth,strengthening supervision and so on.

Objective To study the clinical effect of compound Yisui Shengxue Keli(YSSXKL) on treating ?-thalassemia. Methods By using self-control study method,30 cases of major and intermediate ?-thalassemia had been first treated with placebo for three months,then were treated with YSSXKL in the followed three months in Guangxi province,the high incidence area of the disease. The clinical symptoms,traditional Chinese medicine symptoms and dynamic changes of the blood levels of Hb,RBC,Ret and HbF were observed before and after each treatment. The CRF tables were filled in according to the traditional Chinese medicine symptoms of the patients and the side effects recorded. Results During period of placebo treatment,the main curtive effective indexes Hb and RBC were not obviously raised,while the RBC levels were inversely degraded after the first month of taking placebo orally(P

Objective To discuss the effect of microsurgery of intracranial arachnoid cyst. Methods 42 cases of intracranial arachnoid cyst treated with microsurgery were studied retrospectively.Results Total resection was performed in 23 cases and partial resection in 14 cases. 5 cases received partial resection and communication between cystic cavity and brain cistern. CT scans of 29 cases after operation showed completely obliteration or marked diminution in cystic size. The symptoms and signs of all the patients were improved significantly after a 1-year follow-up.Conclusion The effect of microsurgery of intracranial arachnoid cysts is satisfactory. It is important to communicate cystic cavity with subarachnoid space or brain cistern.

Objective The Application of Circular Mapping during Circumferential Pulmonary Vein Ablation (CPVA) for Atrial Fibrillation Guided by Ensite/NavX System. Methods To evaluate the effect of combined circular mapping on the success rate of CPVA. 61 consecutive cases (40 males and 21 females) were included in the study. 50 cases with paroxysmal atrial fibrillation (PAF) and 11 cases with chronic atrial fibrillation (CAF) underwent CPVA guided by the Ensite/NavX system. A circular electrode catheter was used to map the pulmonary vein (PV) potentials. Pulmonary vein isolation was taken as the endpoint for ablation. Results All the 61 cases underwent the procedure successfully. LPVs were isolated in 34 cases and 35 cases underwent single RPVs isolation. Circumferential ablation of both LPVs and RPVs were carried out in 23 cases. Atrial fibrillation was terminated when delivering radiofrequency energy in 16 cases with PAF and 5 cases with CAF. The termination sites were located near the anterior or posterior roof of the superior PVs in 19 cases and at the mid-portion of the posterior wall from RSPV in 1 case. Atrial fibrillation was terminated when after comple to LPV ablation in 1 case. During the follow-up of 6?2 months, 42 PAF cases and 5 of 11 CAF cases were atrial fibrillation free. The total success rate was 77%. Complications: Pericardium effusion was found in 1 case and disappeared after pericardium puncture and drainage. 1 case developed hemothorax and was cured after thorax puncture and drainage. Conclusion The application of circular mapping during circumferential pulmonary vein ablation guided by Ensite/NavX System contributes to improve the success rate of atrial fibrillation ablation.