Objective To observe the effects of chemo-endocrine therapy on gastric carcinoma (GC). Methods Cancerous tissues from 95 patients with primary GC were examined for the presence of estrogen receptor (ER) and progesterone receptor (PgR). Afterwards, 64 GC patients with recurrent or metastatic conditions were randomly divided into two groups: chemotherapy group and chemo-endocrine therapy group. Results A total of 34.38% ER positive and 16.30% PgR positive rates were found. For ER positive patients, the use of tamoxifen-EAP regimens was more effective than that of EAP alone (P

Objective To explore the changes of susceptibility of different sides and gender in healthy young adults with quantitative susceptibility mapping (QSM).Methods Totally 41 healthy young right-handed adults underwent conventional brain MRI and QSM scan,and the susceptibility maps were obtained by the image post-processing software.Then the ROI of the bilateral frontal grey matter (FGM),frontal white matter (FWM),caudate (CA),globus pallidus (GP),putamen (PU),thalamus (TH),substantia nigra (SN),red nucleus (RN),dentate nucleus (DN),pons (PO),corpus callosum (CC) were manually drawn to obtain magnetic susceptibility on the susceptibility map.The magnetic susceptibility of each ROI was compare between both sides,as well as gender by Mann-Whitney test.Results The magnetic susceptibility of the bilateral ROI of GP was the highest,and SN was followed,FWM was minimum.The susceptibility of bilateral FGM,FWM,CA,GP,PU,TH,SN,RN,DN,PO,CC had no statistically significant differences (all P＞0.05).The magnetic susceptibility in CA of different gender had statistically significant difference (P＜0.05).Conclusion The brain magnetic susceptibility.can be measured by QSM,and it can assess brain iron content quantitatively.

Objective To analyze the changes of susceptibility in acute cerebral ischemia (ACI) using quantitative susceptibility mapping (QSM).Methods Twenty-three patients with ACI who met the criteria underwent conventional brain MR and QSM scan,and the susceptibility maps were obtained with QSM post-processing software in image processing workstation.According to DWI images,ROIs were manually drawn on lesions of ACI to obtain magnetic susceptibility on susceptibility map,including cortical gray matter (CGM),subcortical white matter (SWM),caudate (CA),globus pallidus (GP),putamen (PU),thalamus (TH),substantia nigra (SN),dentate nucleus (DN) and pons (PO).Then magnetic susceptibility of contralateral position was obtained.According to whether cerebral microbleeds (CMBs) were observed,the ACI patients were divided into CMBs group and non-CMBs group.The magnetic susceptibility of groups and different ROIs of ACI and the contralateral area were compared statistically.Results There was significant difference in magnetic susceptibility between CMBs group [(79.04 ± 52.25) × 10-9 ppd] and non-CMBs group ([-4.01 ± 44.57] × 10 9 ppd;Z=-3.297,P =0.001).The difference of magnetic susceptibility between the lesion side and the contralateral side ([-12.10±16.75]× 10-9 ppd) was statistically significant in CMBs group (Z=-3.296,P=0.001),but not in non-CMBs group (contralateral side [1.61 ±32.77] × 10-9 ppd;Z=-0.157,P=0.875).According to the location of ROIs,magnetic susceptibility had statistical differences only in PO,CGM and contralateral side (Z=-2.023,--3.130,P=0.043,0.002).Conclusion QSM can be used to quantitatively analyze magnetic susceptibility of ACI lesions and find CMBs,therefore is helpful to guiding treatment.