Objective To develop a model of be nzene induced aplastic anemia in mice and to observe pathology of aplastic anemi a induced by benzene;Methods we tried to establish a model of benzene induced aplastic anemia in mice,then we studied pathology of aplastic anemia and the pr evention of amifostine on the model.(1) CD1 male mice were injected subcutaneou sly with benzene +corn oil three times a week,and randomly assigned to four gro ups according to the dose of benzene administrated:B1group(0.5ml/kg),B2group( 1.0ml/kg),B3group(1.5ml/kg),B4 group(2.0ml/kg),C group (injected intraperi toneally with 200mg/kg amifostine 30min before benzene administrated on the basi s of the aplastic anemia model as amifostine treated group),while A group treat ed with only corn oil as control,all the groups were complement with corn oil t o 4ml/kg;Before and 2 days after benzene were administrated 10,15,20 and 25 t imes respectively,all the groups mice were killed respectively ,the parameters tested were as following:general condition,peripheral blood smear,histopatho logy of bone marrow 、liver,spleen and PCNA,TUNEL.Results Compared with the control group,some parameters were changed in each model group,but only the pa rameters in B4 group were significantly different from the control group.After 25 times of benzene administration,compared with the control group (A group),B4 group mice showed 18.51% body and 63.86% spleen weight loss (P

Objective To evaluate the incidence and risk factors of postoperative delirium in patients post permanent pacemaker implantation.Methods Patients underwent permanent pacemaker implantation in our department from September 2013 to February 2015 were included in this study.Delirium was measured by the confusion assessment method on the first three postoperative days.All the patients were divided into the postoperative delirium group and the non-delirium control group according to whether new onset delirium was diagnosed.Risk factors significantly associated with postoperative delirium detected by univariate analysis were entered into multivariable analysis to define the independent predictors of postoperative delirium.Results A total of 225 patients were enrolled in this study.The incidence of postoperative delirium was 5.3％.Patients developing postoperative delirium were older ((83 ± 5) years vs.(74 ± 11) years,P =0.002),had a significantly higher incidence of blood pressure fluctuations (58.3％ (7/12) vs.4.7％ (10/213),P＜0.001),hyponatremia (25.0％ (3/12) vs.5.2％ (11/213),P=0.030) and had higher systolic blood pressure ((157 ± 35) mmHg vs.(136 ± 22) mmHg,1 mmHg =0.133 kPa,P =0.007).However,patients developing postoperative delirium had lower preoperative average heart rate ((47 ± 18)bpm vs.(58 ± 15)bpm,P =0.007).Muhiple regression analysis showed that advanced age (OR =2.984,95 ％ CI:1.226-7.624,P =0.016) and blood pressure fluctuations (OR =27.393,95％ CI:6.735-111.417,P ＜0.001) are the independent risk factors for pacemaker patients with postoperative delirium.Conclusion Advanced age and blood pressure fluctuations are independent risk factors of postoperative delirium in patients post permanent pacemaker implantation.

ObjectiveTo observe the effect of hyperbaric oxygen therapy (HBOT) combined with repetitive peripheral magnetic stimulation (rPMS) on ankle motor function and balance of stroke patients. MethodsFrom April, 2022 to March, 2023, 96 patients in the First Affiliated Hospital of Bengbu Medical College were randomly divided into control group (n = 32), rPMS group (n = 32) and combined group (n = 32). The control group received conventional rehabilitation; rPMS group received rPMS on the basis of the control group; and the combined group received HBOT on the basis of rPMS group, for two weeks. Before and after treatment, the plantar weight-bearing ratio of the affected side, Berg Balance Scale (BBS), active range of motion (AROM) of ankle dorsiflexion of the affected side, and integrated electromyographic (iEMG) values during maximum isometric contraction of the tibialis anterior and gastrocnemius muscles were measured. ResultsTwo cases dropped out in each group, and 90 cases were finally included, and no adverse events occurred during treatment. Before treatment, there was no significant difference in plantar weight-bearing ratio of the affected side, BBS score, AROM of ankle dorsiflexion of the affected side, and iEMG of tibialis anterior and gastrocnemius among three groups (F < 2.070, P > 0.05). After treatment, all the indicators significantly improved in all the groups (|t| > 27.004, P < 0.001), and they were better in the combined group than in rPMS group and the control group (P < 0.001); except the proportion of plantar weight-bearing on the affected side, the other indicators were better in rPMS group than in the control group (P < 0.001). ConclusionrPMS can promote the recovery of ankle motor function and balance of stroke patients, and the effect combining with HBOT is better.