Objective To study the CT features and the diagnostic value of ovarian tumors in adolescent.Methods CT findings of ovarian tumors in adolescent proved by operation and pathology in 29 cases were retrospectively analyzed and compared with surgical and pathological results.Results Of 29 case , there were 18 cases benign tumors and 11 cases malignant tumors . Among them,there were ovary germ cell tumors 19 cases ( 65.5% ) , epithelial tumors 5 cases ( 17.2% ) , nonneoplastic cystic 3 cases(10.3%) and sex cord stromal tumors 2 cases (7%). CT manifestations included 17 cystic mass ,6 cystic-solid mass and 10 solid mass,in which benign tumors more seen cystic mass and solid in malignant. Torsion of ovarian tumors was found in 5 cases, haemorrhage in cystic mass was detected in 6 cases.Conclusion CT is a valuable imaging modality in the diagnosis of ovarian tumors in adolescent.

Objective To analyze the multi-slice spiral CT(MSCT) angiographic features of hepatic hemangioma accompanied with peripheral arterial-portal shunt(APS),and to assess the MSCT diagnostic ability and clinical value for peripheral APS.Methods 12 cases of hepatic hemangioma accompanied by peripheral APS underwent triphase enhanced MSCT scan,the images were post-processed with maximum intensity projection(MIP),volume rendering(VR) and then analysed.Results During hepatic arterial phase,the peripheral APS and transient hepatic parenchymal enhancement(THPE) could be visualized on MIP and VR.APS were classified into four types according to the findings on VR and MIP.TypeⅠ: Branch of the portal veins early enhancement in peritumoral wedge-shaped enhanced area,more frequently appeared as parellel track sign;TypeⅡ: Showed early opacification of small portal branchs near tumors,APS more frequently found in peritumoral wedge-shaped enhanced area;Type Ⅲ:Included both typeⅠand typeⅡ signs;Type Ⅳ: Only showed peritumoral THPE.Conclusion MSCT angiography provides a new effective technique for demonstrating and understanding peripheral APS and THPE.

Objective To explore the functional mechanism of a Chinese medicine compound “Qiangzhizufang”on rat model of Tourette syndrome ( TS) combined with fear.Methods The rat model of TS combined with fear was established by intraperitoneal injection of 3,3’-iminodipropionitrile (IDPN) combined with acoustic stimulation.After giving different drug lavage treatment, the changes of behavior of the rat models were assessed by field test and behavior test.The content of DA, TH and TH mRNA in the brain tissue was detected by HPLC, immunohistochemistry and RT-PCR, separately.Results Compared with the normal control group, stereotyped behavior and exercise behavior were increased, freezing time prolonged, but the content of DA, TH and TH mRNA in the brain tissue were not obviously changed in the model control group.Compared with the model control group, the stereotyped behavior and exercise behavior were decreased, content of DA, TH and TH mRNA in the brain tissue was decreased in the “Qiangzhizufang” group. Conclusions The Chinese medicine compound“Qiangzhizufang” can improve the behavior in rat models of TS combined with fear.This effect may be realized through down-regurating TH mRNA expression, reducing the content of TH, and reducing the dopamine synthesis.

Objective To investigate the inhibitory effect on human ACHN cell line and its mice xenograft by using interferon α-1b combined with cyclooxygenase-2 inhibitor and the relevant mechanism in vitro and vivo experiment .Methods ACHN cell and the xenograft mice were devided into 4 groups(IFN-α1b,NS398,IFNα-1b+NS398 and control group).The inhibitory effects were tested by CCK8(Cell Counting Kit 8)assay after AHCN were treated for 24 h and 48 h.The expression of bcl-xl and COX-2 were detected by Western blot .The vol-ume of the xenografts of ACHN cell line and testing the expression of VEGF in xenografts were measured by immunohistochemistry assay .Re-sults Both IFNα-1b and NS398 exerted inhibitory effects on ACHN and this effects showed a rising trend with a increasing concentration of drugs.The combined group was more significant than monotherapy group (P<0.05).Western blot assay showed that IFNα-1b and NS398 downregulated the expression of bcl-xl and COX-2 in ACHN.The combined group was more significant than monotherapy group (P<0.05). The combined group has the greatest inhibitory effects on the xenografts of ACHN cell line compared with monotherapy group and control group(P<0.05).The expression of VEGF in tumor was obiviously inhibited in combined group compared with monotherapy group and con -trol group (P<0.05).Conclusion IFNα-1b combined with NS398 can inhibit the proliferation of ACHN and suppress the tumor growth .