1.The resect margin of hepatectomy for primary hepatocellular carcinoma
Chinese Journal of Practical Surgery 2001;21(4):220-221
Objective To understand the effect of the resect margin(RM)to hepatectomy for primary hepatocellularcarcinoma(PHC).Methods In 544 cases,72 cases were small PHC(≤3cm),473 cases were large PHC(>3cm). Four groups were classified according to the distance of RM The 5-year recurrence rate and survival rate after hepatic resection in each group were analyzed. Results RM with residue cancer or cancer embolus had a high 5-year recurrencre rate and lower survival rate in both small and large PHC. Small PHC with RM≥1.0cm and large PHC with RM≥2.0cm had higher 5-year survival rate and lower recurrence rate. Conclusion We recommend RM≥1.0cm for smallPHC and RM≥2.0cm for large PHC.
2.Transplantation of bone marrow derived mesenchymal stem cells for treatment of spinal cord injury
Xingyao BU ; Zhiqi HUANG ; Yongfu ZHANG
Chinese Journal of Tissue Engineering Research 2006;10(21):183-185
OBJECTIVE: In recent years, in the field of neurosurgery, people have tried to study the mesenchymal stem cells(MSCs) transplantation for treatment of spinal cord injury and review its related studies.DATA SOURCES: We did a computer-search of Medline for spinal cord injury related articles published in English from January 1990 to November 2004, with the key words of "mesenchymal stem cells, transplantation,spinal cord injury". Meanwhile, We also searched Chinese Biomedical Literature Database (CBM) for bone marrow-derived mesenchymal stem cells for transplantation of spinal cord injury related articles published from January 1990 to November 2004, with the key words of "mesenchymal stem cells, transplantation, spinal cord injury" in Chinese.STUDY SELECTION: All articles were selected firstly, and those relevant to progression of mesenchymal stem cells transplantation in spinal cord injury therapy were collected. The full texts of the rest literatures were looked up and the latest evolutional articles were enrolled.DATA EXTRACTION: A total of 32 articles about the mesenchymal stem cells transplantation in spinal cord injury therapy were collected. After the exclusion of repetitive or similar studies, 19 articles met our criteria.DATA SYNTHESIS: Aiming at the spinal cord injury therapy by means of mesenchymal stem cells transplantation, the viewpoints of collected articles were summarized. We found bone marrow derived mesenchymal stem cells could supply lesioned part as filler. Directional regeneration accomplishes the construction of the function that transfers up and down for the nerve cell anchor through surrounding structure. The microenvironment which can inhibit the regeneration of the glial cell, protect the survival of nerve cell body, promote the regeneration of autogenic nerve cells shall be created in transplant. The international successful experience was introduced emphatically, and the most hopeful outlook was suggested.CONCLUSION: The transplanted MSCs survive, migrate to the injury site and differentiate into neurons and astrocytes. Transplantation of MSCs following spinal cord injury may improve the recovery of spinal function and may be an effect way in treating spinal cord injury.
3.Knowledge levels of chronic obstructive pulmonary disease among physicians in primary care and related factors: a survey in Zhumadian City of Henan Province
Xingyao TANG ; Ke HUANG ; Wei LI ; Cunbo JIA ; Ting YANG
Chinese Journal of General Practitioners 2022;21(5):422-429
Objective:To survey the knowledge levels of chronic obstructive pulmonary disease(COPD) among physicians in primary care and related factors.Methods:A questionnaire survey was conducted during December 2020 to December 2021 among 1 232 primary care doctors in Zhumadian City of Henan Province. The questionnaire included basic information, knowledge of COPD and its management, and the training received. The COPD-related knowledge levels and the influencing factors were analyzed using logistic regression model.Results:A total of 1 232 questionnaires were collected, and 1 221(99.1%) were valid, which were included in the analysis. The survey showed that the COPD-related knowledge level was significantly associated with the educational level of primary care physicians(χ2=9.91, P<0.05); and the Pearson correlation analysis showed that the knowledge level was positively correlated with educational level( r=0.09, P<0.05). In terms of risk factors, causes of acute exacerbations, and treatment and management of COPD, there was a linear relationship between the education level and knowledge level(χ2=13.86, P<0.001;χ2=20.93, P<0.001); the Pearson correlation analysis showed that the knowledge level was correlated with higher educational level( r=0.11, P<0.001; r=0.13, P<0.001). In terms of symptoms and diagnosis, there was no correlation between educational level and awareness level(χ2=1.90, P=0.168). Logistic regression model showed that compared to doctors aged 20-30, those aged 31-40 had a higher COPD-related knowledge level( OR=2.24, 95% CI: 1.16-4.30, P=0.016); compare to the doctors with associate degree, doctors with bachelor degree or above had a higher COPD-related knowledge( OR=1.71, 95% CI:1.24-2.37, P=0.001); compared to doctors without professional title, those with primary or middle-rank professional title had a higher knowledge level( OR=1.65, 95% CI: 1.28-2.13, P<0.001; OR=2.15, 95% CI: 1.46-3.16, P<0.001); compared to doctors with training time<3, those with training time ≥3 had a higher knowledge level( OR=1.15, 95% CI: 1.21-2.61, P=0.021). Conclusion:The COPD-related knowledge levels(especially in knowledge of risk factors and causes of acute exacerbations, and treatment and management of COPD) among doctors in primary care are affected by age, educational background, professional title, and the number of training sessions.
4.Diagnosis, treatment and management status of COPD in county-level hospitals of China
Xingyao TANG ; Ke HUANG ; Fangyuan CHEN ; Wei LI ; Jianzhong WU ; Ting YANG
Chinese Journal of Health Management 2022;16(4):222-228
Objective:To understand the current management status of chronic obstructive pulmonary disease (COPD) in county-level hospitals in China from 2020 to 2021.Methods:This survey was led by the China Association of County Hospital President. In 2021, a questionnaire survey was conducted on 633 secondary and tertiary hospitals from 24 provinces, and the questionnaire was filled out according to the actual situation of the hospital in 2020, including diagnosis, treatment, rehabilitation and comprehensive management of COPD. The nature of the hospital was divided into public or private. The type of hospital was divided into general or specialist. The economic zones was divided into eastern, central or western. Through the content of the questionnaire, the influencing factors of the diagnosis, treatment and management capabilities of COPD in county-level hospitals were explored.Results:A total of 633 questionnaires were collected in this survey, and 26 were removed due to the incorrect information or information loss. Thus, a total of 607 questionnaires were finally included in this survey, including 425 secondary hospitals and 182 tertiary hospitals; 591 public hospitals and 16 private hospitals. For the capabilities of diagnosis and treatment, the tertiary hospital was significantly better than the secondary hospital on the availability of respiratory outpatient clinics, COPD outpatient clinics, outpatient comprehensive clinics, respiratory ward and intensive care unit (ICU) (94.5% and 78.4%, 51.1% and 32.7%, 79.7% and 67.3 %, 84.6% and 59.8%, 78.6% and 61.9%, respectively) (all P<0.01). In terms of lung function test and bronchodilation test, tertiary hospitals performed significantly better than secondary hospitals ( P<0.05). There was no difference in availability of inhaled bronchodilators and expectorant drugs among different hospital levels, nature, type, and economic zones ( P>0.05). However, the proportion of hospitals with available triple inhalation drugs was lower in secondary hospitals than tertiary hospitals. For the non-drug treatment, the proportion of general hospitals carrying out vaccination was significantly higher than that of specialized hospitals (52.7% and 28.1%, P=0.010). The tertiary hospitals performed significantly better than secondary hospitals in smoking cessation guidance (98.4% and 94.4%, P=0.031). In terms of rehabilitation, tertiary hospitals also performed significantly better than secondary hospitals (79.7% and 61.9%, P<0.001). The proportion of hospitals carrying out long-term management of COPD in tertiary hospitals was significantly higher than secondary hospitals, and the proportion in public hospitals was significantly higher than private hospitals (80.2% and 61.2%, 68.2% and 18.8%, both P<0.001). Conclusions:County hospitals in China have a good overall performance in the diagnosis and drug treatment of COPD, but need to be further improved in non-drug treatment, rehabilitation, and comprehensive management. The hospital level is the main factor affecting the management ability of COPD. The nature and type of hospital mainly affect the construction of departments and comprehensive management of COPD.
5.Screening status of high-risk population of chronic obstructive pulmonary disease in areas where “Happy Breathing” is running
Wei LI ; Ke HUANG ; Xingyao TANG ; Fang FANG ; Cunbo JIA ; Ting YANG
Chinese Journal of Health Management 2022;16(2):77-82
Objective:To analyze the screening status of high-risk population of chronic obstructive pulmonary disease (COPD) in areas where “Happy Breathing” project was carried out.Method:There were 1 008 518 COPD screening questionnaires (COPD-SQ) filled out in 18 pilot areas of “Happy Breathing” program from November 2017 to October 2019. Within subjects who scored 16 points or more with COPD-SQ, 63 523 of them underwent pulmonary function tests before bronchodilator inhalation. Stratified analysis, chi-square test and other statistical methods were performed to analyze the distribution of COPD high-risk groups, the prevalence of COPD among high-risk groups and risk factors of COPD.Results:Results in this study suggested that the high-risk population of COPD accounted for 18.99% (191 498/1 008 518) of the population who received the questionnaire screening. Among the high-risk population who received lung function test, 31.59% (20 070/63 523) were screened and diagnosed as COPD patients. As for risk factors of COPD, the proportion of high-risk population was higher in people with a smoking index ≥600 compared with never-smokers (54.20% vs 12.60%), and the prevalence of COPD was also higher in people with a smoking index ≥600 (35.62% vs 25.22%); people who were exposed to second-hand smoke almost every day also showed an increased proportion of high-risk groups (27.39% vs 10.97%) and a high prevalence of COPD (31.36% vs 27.93%) than those without second-hand smoke exposure; the presence or absence of biofuel exposure also caused the difference in the proportion of high-risk groups (33.92% vs 13.11%); compared with people without a family history of respiratory diseases, the proportion of high-risk groups (56.38% vs 16.42%) and the prevalence of COPD in high-risk groups (32.40% vs 29.19%) were both higher in those with family history of respiratory diseases.Conclusion:The high-risk group of COPD accounts for a high proportion of the screened population, suggesting that the “Happy Breathing” project is feasible and necessary in COPD screening, which is helpful for the development of COPD diagnosis and treatment.
6.Chloroplast DNA reveals genetic population structure in Sinomenium acutum in subtropical China.
Chun GUO ; Ying HE ; Xiyao ZENG ; Xingyao XIONG ; Ping QIU ; Xueshuang HUANG ; Hua YANG
Chinese Herbal Medicines 2023;15(2):278-283
OBJECTIVE:
The population density and diversity of Sinomenium acutum (Menispermaceae) have been greatly reduced recently by overharvesting for medicinal purposes in China. Therefore, it is urgent that the remaining populations are investigated, and that strategies for the utilization and conservation of this species are developed. This study aimed to find the possible glacial refugia and define the genetic diversity of S. acutum for its proper utilization and conservation.
METHODS:
A total of 77 S. acutum samples were collected from four locations, Qinling Mountains, Daba Mountains, Dalou Mountains, and Xuefeng Mountains, in subtropical China. Genetic diversity among and between these populations were phylogenetically analyzed using four chloroplast DNA molecular markers (atpI-atpH, trnQ-5'rps16, trnH-psbA and trnL-trnF).
RESULTS:
A total of 14 haplotypes (C1 to C14) were found in collected samples. Haplotypes C1 and C3 were shared among all populations, with C3 as the ancestral haplotype. Haplotypes C11 and C12 diverged the most from C3 and other haplotypes. No obvious phylogeographic structure was found in four locations using the GST/NST test. There is no evidence of rapid demographic expansion in S. acutum based on the mismatch distribution, and the results of Tajima's D test, and Fu's FS test. Our analyses of molecular variance revealed a high level of genetic variation within populations. In contrast, the genetic differentiation among S. acutum populations was low, indicating frequent gene flow.
CONCLUSION
Xuefeng, Dalou, and Daba Mountains were possible glacial refugia for the populations of S. acutum. C1, C3, C11 and C12 haplotypes of S. acutum should be carefully preserved and managed for their genetic value.