1.Association of serum uric acid with metabolic syndrome and its components
Ying HU ; Lixin SHI ; Qiao ZHANG ; Nianchun PENG ; Xingxia WANG
Chinese Journal of Endocrinology and Metabolism 2014;30(9):765-768
Objective To explore the association of serum uric acid (UA) with metabolic syndrome (MS) and its components.Methods A total of 1 512 inhabitants aged 20 years old and above in Zhaiji community of Guiyang urban areas were investigated from November 2009 to February 2010 by adopting stratified cluster sampling method (634 males and 878 females).All subjects were asked to fulfill the questionnaires and to measure the height,weight,waist circumstance (WC),and blood pressure ; and to undertake oral glucose tolerance test.Venous blood samples were drawn to measure UA,fasting plasma glucose,2 h postprandial plasma glucose,triglyceride (TG),total cholesterol,high density lipoprotein cholesterol,low density lipoprotein cholesterol,and fasting insulin.Results (1) Age,body mass index (BMI),WC,TG,and blood pressure,and homeostasis model assessment of insulin resistance (HOMA-IR) increased with UA (all P<0.05).(2) UA was positively associated with the risk of MS (P< 0.05).After adjusting for age,sex,BMI,waist-to-hip ratio (WHR),and HOMA-IR,the risk of MS in individuals with the highest uric acid quartiles was significantly increased compared to those with the lowest quartile (OR =2.86,95 % CI 1.70-4.84,P<0.05),and this finding was especially evident in females (OR=2.80,95% CI 1.51-5.17,P<0.05).(3) UA was strongly related to WC (OR =1.76,95% CI0.95-3.27,P<0.05),blood pressure (OR =1.66,95 % CI 1.13-2.43,P<0.05),and TG (OR =2.80,95% CI 1.97-3.96,P<0.05) after adjustment for age,sex,BMI,WHR,and HOMA-IR.Conclusion The prevalence of MS increased with UA.Higher UA level may be an independent risk factor for MS.
2. The study of using salvianolate treat acute lung injury in rats induced by paraquat
Zhongwei WANG ; Xingxia LI ; Xiangdong JIAN ; Zhongchen ZHANG ; Baotian KAN
Chinese Journal of Industrial Hygiene and Occupational Diseases 2017;35(5):342-347
Objective:
To establish to paraquat poisoning acute lung injury animal model to study the therapeutic effect of Salvia polyphenols acid salt of paraquat-induced acute lung injury.
Methods:
Adult male Wister rats 120, were randomly divided into three groups: the paraquat exposure group, the start of the experiment to give a one-time 20% paraquat dope orally 50 mg/kg body weight of rats; salvianolate treatment group, the start of the experiment paraquat to give a one-time 20% the stock solution orally 50 mg/kg body weight of rats, and then given daily intraperitoneal injection of 200 mg/kg body weight of rats salvianolate; blank control group was given the same amount normal saline. The exposure group, the treatment group and control group rats were sacrificed after anesthesia in the 3rd, 7th, 14th, 21st day from the beginning of the experiment respectively, and taken out and preserved venous blood specimens and lung tissue to be tested. Venous detection heme oxygenase-1 (HO-1) , the lung tissue detection heme oxygenase-1 (HO-1) , hydroxyproline (HYP) . And do biopsy specimens from some of the lung tissue, HE and Masson staining observed by optical microscope.
Results:
Compared with control group, model group 7, 14, 21 days had elevated levels of serum and lung tissue HO-1 (all
3. A group of occupational acute methyl bromide poisoning incident
Wenjun WANG ; Xingxia LI ; Xiangdong JIAN ; Yuzheng WU ; Ke WANG ; June JIA ; Zhongchen ZHANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2017;35(4):291-292
Objective:
To investigate a mass of occupational acute methyl bromide poisoning incident and analyzed their clinical data.
Methods:
To investigate an incident a mass of occupational acute methyl bromide poisoning in occurred in Shandong province in November 2016, and the clinical datas of 3 cases of severe patients with methyl bromide poisoning were analysed.
Results:
This event was a sudden occupational poisoning incident. Lack of vocational training and irregularities is the main reason for the accident 3 patients with nervous system, respiratory system, circulatory system, urinary system damage is given priority to, after comprehensive rescue treatment, 2 cases died and 1 case survived.
Conclusions
Methyl bromide can cause severe poisoning, has high mortality in patients with acute severe poisoning.