Objective To test the effect of EPO on anemia of preterm infant. Methods Thirty preterm infants less than 35 weeks of gestational age from three different hospitals were devided ramdomly into EPO group of 16 cases and control group of 14 cases. The infants in EPO group were received rh EPO 400 IU/(kg?d) subcutaneously twice a week for 4 weeks from 7 days old, together with oral supplementation of ferrous sulfate at a dossage of 3~5 mg/(kg?d) in both groups. Hemoglobin(Hb) and reticulocytes(Ret) were measured at 42 days of age. Results The hemoglobin was higherin the EPO group[(999?29)g/L vs (905?25)]g/L, P 0.05). Conclusion The is lower EPO level in prematures and efficiency of rh EPO in the treatment of anemia of preterm infants. There is no observed substantial adverse effects.

Expression of apelin mRNA in the isolated mouse adipocytes was confirmed by Northern blot. The level of apelin mRNA increased during stage of differentiation of 3T3-L1 cells. Insulin up-regulated the apelin expression in 3T3-L1 adipocytes, suggesting that apelin expression in adipocyte may correlate with obesity, insulin resistance and hypertension.

Objective:To investigate the effectiveness of mindfulness training improving negative emotions, furthering to explore the mediating effect of the improvement of mindfulness levels for the training effects.Methods:Randomized control trail was used in this research.Ninety participants who suffered negative e-motions and resolved to alleviate stress by mindfulness training were recruited by lecture.They were randomized in-to mindfulness training group or waitlist control group,and 79 of them completed the intervention (38 in mindful-ness training group and 41 in waitlist control group).Participants in mindfulness training group received an 8-week mindfulness training,while participants in waitlist control group received no intervention.Participants were assessed with the Five Facet Mindfulness Questionnaire (FFMQ,measuring mindfulness level)and Brief Profile of Mood State (POMS,measuring emotion)before and after intervention.Results:After 8-week intervention,participants in mindfulness training group got significantly higher total scores of FFMQ compared with baseline [(125.9 ±11.9) vs.(121.2 ±12.5),P<0.01].Participants in mindfulness training group also got significantly higher total scores of POMS,and the intensity-anxiety,depression-frustration,and fatigue scores of POMS compared with baseline (Ps<0.01).There were no significant differences between posttest and baseline on any scores in waitlist control group (Ps>0.05 ).The improvement of total scores of FFMQ mediated the reduction of total scores of POMS (95%CI=-6.24--0.73),and the intensity-anxiety (95%CI=-1.65 ~-0.12),depression-frustration (95%CI=-1.63--0.14),and fatigue scores (95%CI=-1.72--0.20)of POMS caused by mindfulness training.Conclusion:Mindfulness training could improve participants'negative emotions,and the enhanced mindfulness levels caused by mindfulness training will play a very important role for the improvement of negative emotions.

Objective To investigate the relationships among perceived stress,mindfulness level,and sleep problems,and to indicate the mediating role of mindfulness level in the relationship between perceived stress and sleep problems.Methods For 179 undergraduate students,the Five Facet Mindfulness Questionnaire (FFMQ),Chinese Perceived Stress Scales (CPSS) and Athens Insomnia Scale (AIS) were used to measure.Results The scores of the scales were (120.43 ± 1 1.23) for FFMQ,(40.17 ± 6.86) for CPSS and (5.28 ± 4.04)for AIS.Pearson correlation analysis showed that perceived stress was negatively correlated to mindfulness level (r =-0.602,P =0.000) and positively correlated to sleep problems (r =0.459,P =0.000) and that there was significant negative correlation between mindfulness level and sleep problems (r =-0.427,P =0.000).Hierarchical linear modeling showed significant partial mediation of mindfulness level on the association between perceived stress and sleep problems.Conclusion Mindfulness level partly mediated the positive link between perceived stress and sleep problems.

Objective To evaluate the effect of supplementation with human milk fortifier (HMF) produced by human milk protein in low birth weight infants.Methods Eighty seven low birth weight infants undergoing neonatal intensive care were divided into 4 groups randomly,human milk +HMF 9307(enriched protein 6 g/L)and human milk;formula +HMF 9308(enriched SIgA 500 mg/L)and formula.Results The weight gain was faster in human milk+HMF 9307 group than that of human milk group(13.8 g?kg~(-1)?d~(-1).vs.9.4 g?kg~(-1)?d~(-1),P

0.05). Conclusion: RVPI and RSVPI of can be used as a measure to assess VPF and speech articulation of CP patients after operation.

Objective Explore the diagnostic effect of high-sensitivity C-reactive protein (hs-CRP) in pediatric infectious diseases. Methods The BNProSpec automatic protein analyzer was used to detect the serum hs-CRP levels of children including 246 cases of bacterial infection, 132 cases of virus infection and 72 cases of healthy children (control group) . Results The serum hs-CRP levels were 57.2±19.5 mg/L,4.6±3.2 mg/L and 1.7 ±0.4mg/L in children of the bacterial infection, virus infection and normal control group, respectively. Conclusion The serum levels of hs-CRP in children with bacterial infection were significantly higher than those in other two groups,and the difference was significant ( <0.05) . The results suggested that serum hs-CRP testing has great application value in the diagnosis of pediatric infectious diseases, treatment and prognosis.

Objective To evaluate the feasibility and clinical efficacy of intraperitoneal laparoscopic partial nephrectomy for T1a peripheral renal neoplasms. Methods Intraperitoneal laparoscopic partial nephrectomy was performed without renal artery occlusion for T1a peripheral peripheral renal neoplasms. The operative time, bleeding volume and complications were observed and the clinical experience was summarized. Results From October 2014 to January 2017 ,there were 10 patients:7 males and 3 females. All patients had T1a peripheral renal tumors. 10 patients underwent operation successfully ,of which 1 case developed temporarily blocked renal artery in the surgery due to hemorrhage. There was no referral during surgeries. The operative duration was 108 to 210 min,with a median of 135 min. The estimated blood loss was 100 to 750 mL,with a median of 320 mL. Followed up duration was 2 to 24 months (median 12 months),there were not postoperative renal secondary bleeding , leakage and other complications. No recurrence of tumor was found. Conclusion It is feasible and safe to exercise intraperitoneal laparoscopic partial nephrectomy without renal artery occlusion in the treatment of T 1a peripheral renal tumors,which can protect renal function to the greatest extent.

BACKGROUND: According to up-to-date development, the best timing to repair cleft palateis at 9-12 months old after birth when the articulation does not begin to develop.However, there are many over-eight-year-old children who still suffer from unrepaired cleft palate. Therefore, it is veryimportant to adopt proper surgery for these patients to improve palate form and articulatory function. OBJECTIVE: To study the characteristics of the cleft palate in patients of over 8 years old and the effects of palate repair and posterior pharyngeal flap transplantation (PPFT) on articulation. DESIGN:A controlled study with children patients as subjects. SETTING: Department of Maxillofacial Surgery, Medical College of Stomatology, Fourth Military Medical University of Chinese PLA PARTICIPANTS: Twenty-four children patients of cleft palate who were treated in the Department of Maxillofacial Surgery ,Medical College of Stomatology, Fourth Military Medical University of Chinese PLA from January 2000 through December 2003 were enrolled in the study. Fourteen were male and ten female. Their ages varied from 8 to 20 years old (mean 13.8 years). Three cases were bilateral complete cleft palate and twelve cases were unilateral complete cleft palate. Nine were incomplete cleft palate. METHODS :Two flap palatoplasty and upper pedicle PPFT were conducted in all the patients. In thirty days after surgical treatment, the patients were asked to repeat the words of a doctor in the phonetic lab with his or her lips 10 cm away from microphone. The words of the patients were recorded and evaluated subjectively by 5 doctors specialized in pathologic phones. MAIN OUTCOME MEASURES :The palatopharynx was observed with nasopharyngoscope before and after operation. And the improvement of nasal gas leakage and enhanced rhinophonia were also evaluated. RESULTS: The repaired cleft palate was healed in the first intention in all the patients. The soft palate retreated satisfactorily and the palatopharynx was apparently closed, which created good preconditions for articulation. The patients' articulation was also improved in different degrees. All the 24 patients had the fourth grade of enhanced rhinophonia and nasal gas leakage before repairing. After palate repair and PPFT, the enhanced rhinophonia and nasal gas leakage of grade 1 was in 3 patients, grade 2 in seven, grade 3 in six and grade 4 in eight patients. CONCLUSION: The combination of palate repair and pharyngoplasty is able to improve the form of soft palate and the articulation of over-eightyear-old patients with cleft palate.

Objective To report the clinical, myopathological and genetic features in myofibrillar myopathy (MFM) with numerous cytoplasmatic-spheroid bodies. Methods Ten patients in 5 successive generations began to present progressive proximal limbs weakness at 35 to 40 years old. Additionally, 4 cases manifested diarrhea and 6 cases accompanied with cardiorespiratory symptoms. An open biopsy was performed on the proband. In addition to histological, enzymhistochemical staining and ultrastructural examination, immunohistochemical staining with antibody against tau, desmin, ubiquitin, dysferlin, dystrophin-C', dystrophin-N' and dystrophin-R were done. All the exons of the MYOT, CRYAB, DESMIN, LDB3, LMNA, SEPNI gene and the FLNC exon 48 were analysed. Results Cytoplasmatic bodies and spheroid bodies were found in the fibers. The deposited material were positive for tau, desmin, ubiquitin, dysferlin and dystrophin-R, dystrophin-C'. Electron microscope showed granular dense Z-disc material in the inclusions which were surrounded by thin filament. There was no mutation in the above exons of the 7 candidate genes. Conclusions Myofibrillar myopathy involves multiple system impairment. Cytoplasmatic and spheroid bodies contain microtubule and membrane associated protein. The disease might be induced by some unknown genetic abnormities.