1.Effect of berberine combined with levofloxacin on myocardial enzymes, isozymes and serum inflammatory factors in children with diarrhea
Hao CHEN ; Qiushi LIU ; Qingsheng LE ; Xing WANG
Chinese Journal of Biochemical Pharmaceutics 2015;(9):97-99
Objective To analyse effect of berberine combined with levofloxacin on myocardial enzymes, isozymes and serum inflammatory factors in children with diarrhea.Methods 58 patients who were diagnosed with pediatric infectious diarrhea in our hospital were collected.All patients were randomly divided into experimental group and control group, 29 cases in each group.two groups of patients were given routine treatment, including infusion, maintaining water and electrolyte balance, supplemental calories etc.On the basis of routine treatment, control group was intravenous dripped with levofloxacin injection 200mL,one times per day,and experimental group was treated with berberine hydrochloride tables 0.2 g orally on the basis of control group.The treatment period was one week of two group.After one week of treatment, the serum levels of myocardial enzymes, isozymes, inflammatory factors and clinical curative effect were detected in all patients.Results Compared with control group post-treatment,the serum AST,ALT and LDH levels were lower than that of experimental group(P<0.05);the serum CK and CK-MB levels were lower than that of experimental group(P<0.05);the serum TNF-α,IL-6 and IL-10 levels were lower than that of experimental group(P<0.05);the total effective rate was higher in experimental group(P<0.05).Conclusion The berberine combined with levofloxacin can significantly reduce the serum myocardial enzymes, isozymes and serum inflammatory factors in children with diarrhea, improve clinical curative effect.
2.The Study on the Relationship between Diet Intake and Impaired Glucose Metabolism in Adult Residents in Guangxi
Zheng-Zhu TANG ; Xing-Le CHEN ; Zhao-Yong HUANG
Chinese Journal of Prevention and Control of Chronic Diseases 2006;0(06):-
Objective To explore the relationship between diet intake and diabetes mellitus(DM) and impaired fasting glucose (IFG) in adult residents in Guangxi,so as to provide scientific basis for dietary prevention.Methods 2 281 people(1 020 from urban areas and 1 261 from rural areas) aged 18 years and above were selected from 4 cities and 4 countrysides in Guangxi through a multistage stratified random sampling.The investigation included the meal investigation,medical examination and blood assay. Results Total 37 people(26 from urban and 11 from rural) suffered from DM and 26 people(15 from urban and 11 from rural) had IFG,the general prevalence rate of Impaired Glucose Metabolism(IGM) was 2.8%(4.0% for urban and 1.7% for rural);It showed that the prevalence of IGM in city was obviously higher than that in the countryside(P
3.Hotspots in studies on medical information education based on data source of core journals
Wei PAN ; le Le DENG ; Min ZHANG ; zhi Xing CHEN
Chinese Journal of Medical Library and Information Science 2017;26(10):75-80
The hotspots and frontiers in studies on medical information education were identified with key words cluster algorithm and burst words detection algorithm by making use of CiteSpaceⅢwith 540 papers on medical in-formation education published in core journals of medical information education from 2007 to 2016 as sample data, which showed that the 7 hotspots and frontiers in studies on medical information education from 2007 to 2016 in medical information education field of China and can thus provide support for keeping abreast of its development trend and working out its development strategies.
4.Phytochemical and pharmacological progress on peeled stem of Syringa pinnatifolia, a Mongolian folk medicine.
Guo-zhu SU ; Jie CHEN ; Yuan CAO ; Rui-feng BAI ; Su-yi-le CHEN ; Peng-fei TU ; Xing-yun CHAI
China Journal of Chinese Materia Medica 2015;40(22):4333-4338
The peeled stem of Syringa pinnatifolia is a Mongolia folk medicine, mainly distributed in Helan mountain, inner Mongolia and Ningxia provinces of China. It has been used for the treatment of cardiopalmus, angina pectoris, and cardiopulmonary diseases for a long history. Contemporary research revealed the presence of major lignans, sesquitepenes, and essential oils, and showed myocardial ischemia related diseases. This review summarizes the plant origins, taxonomic disputes, phytochemical and pharmacological research progress, hopefully to provide reference for full medicinal utilization, clarification of biological effective substance, and drug development.
Animals
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Drug Therapy
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Drugs, Chinese Herbal
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chemistry
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pharmacology
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Humans
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Medicine, Mongolian Traditional
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Molecular Structure
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Syringa
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chemistry
5.Complete genome sequencing of enterovirus 71 (EV71) HENAN08 strain isolated in Henan province
Shao-Li ZHANG ; Bian-Li XU ; Wan-Shen GUO ; Li CHEN ; Hai-Yan WEI ; Yan-Hua DU ; Xing-Le LI
Chinese Journal of Epidemiology 2009;30(9):938-941
strains (isolated in 2008). Conclusion The HENAN08 strain might belong to the same genogroup with AnhuiFY08 and Zhejiang08 strains as C4 gene subtypes.
6.Surveillance on Japanese encephalitis in Henan province, 2006-2010
Xiao-Yan TANG ; Kai KANG ; Xing-Le LI ; Hao-Min CHEN ; Bian-Li XU
Chinese Journal of Epidemiology 2011;32(11):1128-1130
Objective To analyze the epidemiological characteristics and risk factors of Japanese encephalitis (JE) in Henan province.Methods Epidemiological characteristics and related factors of JE cases in Henan province from 2006 to 2010 were analyzed with descriptive epidemiological method and JE IgM antibodies of the serum or cerebrospinal fluid of the cases were detected by ELISA.Results 3099 cases were reported in Henan province from 2006 to 2010.The incidence fluctuated from 0.39/100 000 to 1.08/100 000,and the incidence rate was decreasing.Patients were concentrated mainly in Xinyang,Nanyang and Luoyang cities,which accounted for 60.12% of the total.The peak season was in July-September,accounted for 93.26% of all the cases.Most cases were in 0-14 year old (83.61%) in the whole province.However,in Luoyang city,number of cases in the ≥ 15 year old group,had an obvious increase (57.63%).Compared with the provincial data,significant difference was found between the two ≥ 15 year old groups (x2=330.0341,P<0.05)statistically.20.23% of the JE cases were vaccinated but 75.54% of them did not complete the whole course.79.77% of the cases were not sure if they had received the vaccination.42.98% of the JE cases were confirmed through laboratory tests but other 45.95% of them were clinically diagnosed,with the rest 11.07% were suspected cases.Conclusion The distribution of JE cases showed seasonal,regional characteristics and crowd differences in Henan province.Basic immunization and the program on strengthening immunization of JE should be further standardized.The laboratory diagnosis rate of JE cases should be further improved.
7.Palliative Gamma knife in treating elderly patients with brain metastasis
Cai-Xing LIU ; Song-Sheng SHI ; Wei-Zhong YANG ; Jian-Le CHEN
Chinese Journal of Neuromedicine 2012;11(8):792-795
Objective To evaluate the therapeutic effect of Gamma knife radiosurgery (GKRS) on patients aged ≥65 years who presented with brain metastasis. Methods The clinical treatment and follow-up data of 134 patients,admitted to and treated with GKRS in our hospital from March 2004 to March 2010,were analyzed.These 134 patients totally underwent 212 GKRS for 403 metastases.The median maximal and marginal doses were (29.3±8.4) Gy and (15.9±4.8) Gy,respectively.Kaplan-Meier survivor analysis was utilized to calculate the median survive time and multivariate analysis was employed to determine the clinical factors influencing the treatment outcome. Results Of the 372 metastasis followed by imaging,complete response was achieved in 66 lesions (17.7%),partial response in 174 lesions (46.8%),no change in 94 lesions (25.3%),and partial progression in 38 lesions (10.2%).Median survival was 10.9 months.Grade of recursive partitioning analysis (RPA),number of tumors,scores of Karnofsky performance scale (KPS) and status of primary malignancies were found to be factors influencing the efficacy (P<0.05). Conclusion GKRS for patients aged over 65 years with brain metastases is an effective and safe treatment method that appears to improve survival and is helpful in maintaining relative good life quality in selected population
8.Successful pregnancy following intracytoplasmic sperm injection?embryo transfer in a patient with premature ovarian insufficiency: a case report.
Wei-Xu MA ; Xin CHEN ; Xing-Yu ZHOU ; Xue-Lan LI ; Wan-le CHEN ; De-Sheng YE ; Shi-Ling CHEN
Journal of Southern Medical University 2017;37(10):1418-1422
We report a case of ovarian function fluctuation during long-term follow-up in a patient with premature ovarian insufficiency (POI). The patient finally obtained clinical pregnancy with subsequent uneventful full-term delivery after several intracytoplasmic sperm injection-embryo transfer (ICSI-ET) cycles. This case demonstrates that hormone replacement therapy (HRT) and assisted reproductive therapy should be applied as soon as possible to young patients with POI who have a strong desire for pregnancy in the absence of contraindications. This strategy helps such patients obtain pregnancy and delivery before the exhaustion of ovarian function.
9.Epidemiology investigation of allergic rhinitis in urban and rural areas of Ningbo and Yongzhou.
Shixiong TANG ; Houyong KANG ; Lingying ZHU ; Xing CHEN ; Ji LI ; Xu LU ; Jianhua ZHANG ; Ling LE ; Peiyun WU ; Jinmei FU ; Jinyong TANG ; Yuehong CHEN ; Guihua XIA
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2008;22(14):642-644
OBJECTIVE:
To investigate the epidemiological characteristics of allergic rhinitis (AR) in urban and rural areas of Ningbo and Yongzhou.
METHOD:
Fifteen fields in the two cities from October 2006 to June 2007 were randomly selected. Cases suspected with symptoms of AR by a self-administered and interview questionnaire were recommended to special examinations for confirmed diagnosis.
RESULT:
1. A total of 9969 individuals from 3803 families were surveyed, of whom 303 suffered with AR. 2. The prevalence rate was 4.10% in Ningbo and 1.65% in Yongzhou (the sex-adjusted rate was 4.10% and 1.64% respectively, and the age-adjusted rate was 4.33% and 1.58%); the population of island inhabitants had the lowest prevalence rate of 0.73%. 3. The prevalence rate in patients with asthma and that with family genetic history was 8% and 12% respectively.
CONCLUSION
It demonstrates that the prevalence rate is higher in Ningbo than in Yongzhou, in urban than in rural and in adolescent than in other ages. Allergic rhinitis may be associated with asthma and related to genetic factors. Allergic rhinitis may be curable.
Adolescent
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Adult
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Aged
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Aged, 80 and over
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Asthma
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epidemiology
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Child
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Child, Preschool
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China
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epidemiology
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Female
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Humans
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Infant
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Male
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Middle Aged
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Prevalence
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Rhinitis, Allergic, Perennial
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epidemiology
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Rhinitis, Allergic, Seasonal
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epidemiology
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Rural Population
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Surveys and Questionnaires
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Urban Population
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Young Adult
10.Epidemic characteristics and viral antibody level among healthy people of Japanese B encephalitis in Henan province in 2010.
Xiao-yan TANG ; Kai KANG ; Si-yuan SHANG ; Chao XU ; Xing-le LI ; Hong-xia MA ; Hao-min CHEN ; Bian-li XU
Chinese Journal of Preventive Medicine 2012;46(10):888-891
OBJECTIVETo understand the epidemic characteristics and viral antibody level among healthy people of Japanese B encephalitis (JE) in Henan province in 2010.
METHODSA total of 433 selected JE cases in Henan province in 2010 were analyzed by descriptive epidemiological method. Xinyang and Luoyang were selected as survey sites in 2010.12 administrative villages were randomly selected from both cities. As the investigation objects, 519 healthy people from the two cities were randomly selected by eight age groups:less than one year old, 1 - 2 years old, 3 - 4 years old, 5 - 6 years old, 7 - 14 years old, 15 - 19 years old, 20 - 59 years old, and above 60 years old. A total of 1008 samples of blood specimens were collected both in May and November, and JE viral antibody was detected by micro-cytopathic effect neutralization test.
RESULTSThe incidence rate of JE was 0.46/100 000 (433/94 130 434) in Henan province in 2010.97.69% (423/433) of the patients were found between July and September, and 81.06% (351/433) were distributed in Nanyang, Xinyang, Luoyang, Zhumadian and Zhoukou city. Children aged 0 to 14 years were the primarily affected group (82.22%, 356/433), the people above 15 years old accounted for 17.78% (77/433) of whole cases in Henan province, but the same group accounted for 65.79% (50/76) of whole cases in Luoyang city, which obviously higher than the percentage in Henan province (χ(2) = 79.57, P < 0.05). Most patients were scattered children in Henan province, accounting for 58.89% (255/433). In Luoyang city, most patients were peasants, accounting for 44.74% (34/76). The antibody positive rate of JE among health people above 15 years old in Luoyang city was 48.94% (46/94), which was lower than it in Xinyang city at 97.78% (88/90). The difference showed statistical significance (χ(2) = 55.42, P < 0.05). The antibody positive rate among healthy people under vaccination was 50.41% (61/121), which was obviously higher than that among people without vaccination, at 16.67% (6/36) in Luoyang city. The difference showed statistical significance (χ(2) = 12.92, P < 0.05). The antibody positive rate among healthy people under vaccination was 67.11% (51/76) in Xinyang city, which was obviously higher than that among people without vaccination, at 46.39% (45/97). The difference showed statistical significance (χ(2) = 7.40, P < 0.05).
CONCLUSIONThe incidence of JE showed seasonal and regional characteristics, there were differences among ages and occupations. The difference was consistent with the difference in viral antibody level among health people in Henan province and Luoyang city.
Adolescent ; Adult ; Antibodies, Viral ; blood ; Case-Control Studies ; Child ; Child, Preschool ; China ; epidemiology ; Encephalitis Virus, Japanese ; immunology ; Encephalitis, Japanese ; blood ; epidemiology ; immunology ; Humans ; Incidence ; Infant ; Middle Aged ; Young Adult