Gestational trophoblastic neoplasia (GTN) includes invasive mole and choriocarcinoma. Before the discovery of effective chemotherapeutic agents for human chorionic gonadotropin (HCG), the survival prognosis for the patients with the disease was very poor. At present, with the setup of sensitive quantitative assays and new drugs to be developed for HCG, most women with GTN can be cured and their reproductive function preserved. The purpose of this paper is to address current opinions regarding the diagnosis, staging, and management of GTN.

Objective To compare color doppler ultrasound examination for the different pathological types of thyroid cancer.Methods 62 cases of thyroid cancer in patients with color doppler ultrasound examination,then compared with pathological examination and compared the different pathological types of thyroid cancer with ultrasound image map features.Results Ultrasound examination showed papillary adenocarcinoma in 31 cases within the hypoechoic,ill-defined in 28 cases,there was calcification in 31 cases,follicular carcinoma in 6 cases、6 cases and 12 cases,there were significant differences between the two groups ( x2 =27.884,20.545,13.964,P =0.000 ),There was no significant difference both in the form of regularity,the nature of the back echo,Vmax and RI.( P =0.427,0.338,0.110,0.872 ).Pathology consistent with papillary carcinoma was 80.0％,follicular carcinoma pathology found was 70.4％.Conclusion Color doppler ultrasound examination of the different pathological types of thyroid cancer had a certain differential diagnosis and it had higher rate of pathological diagnosis.

For a long time, in the field of medical research, due to lack of proper methods, research decision-making process has not made the most of human experience, recommendations and different opinions, viewpoints, and expositions related to subjective interpretation. At present, this problem in the course of the standardized clinical research on traditional Chinese medicine is particularly prominent and needs to be solved urgently. Consensus methods can be used for studying different perspectives within the group and get different levels of "consent" in order to achieve "consensus", especially in the formation of a consensus of experts, which are widely used now. Consensus methods include three frequently used methods such as Delphi method, nominal group technique and consensus development conference. The research team of WHO Western Pacific Regional Primary Osteoporosis Clinical Practice Guideline of Traditional Medicine completed the preparation of good practice points in the first draft after three expert consensus meetings by using consensus development conference method. This article discusses the application of consensus development conference method in the developing process of clinical practice guidelines of traditional medicine.

It is not finally concluded how to standardize the use of qualitative research in the world. Qualitative researchers disagree with each other about this issue. As we know, there have been a large number of articles written in different ways about qualitative research due to the "flexibility", one of its features. Qualitative research is quite different from quantitative research which is easy to control its quality and quality assessment. A series of criteria has been set up for quantitative research. However qualitative research needs to be improved in these aspects, in which qualitative interviews are mostly used at home and abroad at present. Hence, it becomes an important and urgent issue for qualitative researchers to standardly control and assess the quality of qualitative interview.

Qualitative interview can collect data independently and can help modify and explain data when being combined with the quantitative research. The authors of this article introduced some kinds of qualitative interviews and their application in clinical research of traditional Chinese medicine (TCM). It emphasized some aspects of qualitative interview including the origin and definition, classification, basic standards, sampling, data analysis and report writing, quality evaluation and application for TCM clinical research.

The paper aims to explore basic steps, regulation and data analysis methods of semi-structured and in-depth interview studies of clinical research in traditional Chinese medicine (TCM), and to provide some helpful information obtained from the examples for decision making in TCM research field. A pilot study was made with eight interviewees and, based on which, a formal one with twelve interviewees was done in this study. All the recordings were transcribed into verbal manuscripts, categorized into different archives and labeled by letter from A to T. Grounded theory for analyzing qualitative data was used in this study, and cross-case analysis was also made on the basis of case-by-case analysis results. Nine theories with central categories were constructed by three coding procedures from grounded theory. Three kinds of relationships, three types of optimized attitude, and three concerns were obtained from the example study. Nine analyzing conceptual graphs and nine theories related to optimization of TCM clinical research program were established finally. The researchers of large national studies were included as interviewees in the study. A comprehensive and critical data analysis from twelve interviewees for in-depth interview was conducted in accordance with current international qualitative research, and a response theory model focused on optimization of TCM clinical research program was established. The study laid the foundation for using semi-structured and in-depth interview for TCM clinical research.

Objective:To investigate the influential factors of mental health in rural high-school students by structural equation modeling.Methods:447 rural high-school students were tested by Mental Health test,Adolescent Self-rating Life Events Check list,Social Support Scale and Trait Coping Style questionnaire,then theoretical model were established and confirmed for the relationships of life events,social support,coping styles and mental health of rural high-school students.Results:The structural equation modeling fitted the data very well(?2/df=3.56,GFI=0.940,AGFI=0.902,NFI= 0.913,CFI=0.901,RMSEA=0.048),the theoretical model suppose was supported by the use of structural equation modeling.Conclusion:Social supports and coping styles have direct influence on mental health of rural high-school students.Life events have indirect influence on mental health through social supports and coping styles.

NDUFS3 is an essential subunit of mitochondrial NADH:ubiquinone oxidoreductase (complex Ⅰ ) and plays a critical role in the mitochondrial typeⅠ respiration chain.Mutations in this gene are shown to cause neurodegenerative disease such as Leigh syndrome (subacute necrotizing encephalopathy).In recent years,many evidences show that the expression of NDUFS3 proteins are lower in many cancerous cells compared to the corresponding normal cells.It comes to the conclusion that NDUFS3 may play a role in the tumorigenesis.

Objective To assess the efficacy and pathological change of fertility-sparing treatment with progestin for endometrial carcinoma (EC) of stage Ⅰ a and complex atypical hyperplasia (CAH) and to observe the prognosis of the treatment.Methods Nine EC patients of stage Ⅰ a and 21 CAH patients aged under 40 years who desired childbearing and retaining their fertility were enrolled into this study.All patients were given a daily oral high-dose of progestin with duration of treatment ranging from 6 to 9 months.Diagnostic curettage was performed every 3 months as a modality for seeing the histologic change of neoplastic tissues and endometrial tissue.A careful and long-term follow-up is necessary for patients with complete response (CR).Results During the first period of fertility-sparing management,according to histologic change,5 EC patients and 18 CAH patients showed CR with no evidence of endometrial adenocarcinoma or hyperplasia,2 EC patients and 2 CAH patients showed partial response with a regression to complex or simple hyperplasia without atypia,2 EC patients and 1 CAH patient showed stable disease or progressive disease.Accordingly,a total of 26 patients showed CR (26 of 30 patients).The median time to CR was 6 months (range,3 to 21 months) of progestin treatment.The median follow-up time was 55.5 months (range,24 to 104 months) and all patients were alive.During follow-up,among the 26 patients with CR,3 of 6 EC patients achieved CR recurred disease after a median time interval of 10 months (range,6 to 51 months),7 of 20 CAH patients achieved CR had recurrent disease after a median time interval of 12 months (range,6 to 55 months).Four of 7 CAH with recurrent disease achieved CR to progestin retreatment.Eight of 26 patients achieved CR continued a further 3 or 6 months of consolidation therapy,3 of them had recurrent disease,the remaining 18 stopped progesterone treatment after CR and 7 patients had recurrent disease; there was no significant statistical difference between the two groups (P=1.000).EC patients succeeded in 4 pregnancies,CAH patients succeeded in 10 pregnancies,they gave birth to 16 healthy babies in all.Conclusions EC of stage Ⅰ a and CAH had slow progression of symptoms.Progestin treatment in EC of stage Ⅰ a and CAH patients was effective.A careful and long-term follow-up is required because of the substantial high rate of recurrence.Progestin re-treatment in most patients with recurrent endometrial cancer is effective and safe.