Objective To observe the effect of acupuncture at Zusanli (ST36) and Neiting (ST44) plus enema with Chinese medication on the recovery of gastrointestinal function after laparotomy.Method A total of 82 patients who had received laparotomy were randomized into an observation group and a control group, 41 cases each. The control group was intervened by conventional management after thesurgery, while the observation group was additionally given acupuncture at Zusanli and Neiting plus enema with Chinese medication. The gastrointestinal function indicators, total hospitalization duration, symptoms score, clinical efficacy, and patient's satisfaction rating of the two groups were compared.Result The time to restore bowel sound, first anal exhaust time, first defecation time, time to restore general diet, and total hospitalization duration of the observation group were significantly shorterthan those of the control group, and the observation group had significantly more cases who had anal exhaust within 48 h after the surgery (P<0.05). After the treatment, the symptoms score in the observation group was markedly lower than that in the control group (P<0.05). The clinical efficacy and total effective rate of the observation group were significantly superior to those of the control group (P<0.05). The patient's satisfaction rating and total satisfaction rate of the observation group were significantly superior to those of the control group (P<0.05).ConclusionAcupuncture at Zusanli and Neiting plus enema with Chinese medication can effectively promote the recovery of gastrointestinal function, mitigate the enteroparalysis symptoms, boost thepostoperative recovery, and enhance the general satisfaction rating.

Objective To investigate the outcome of community seniors after 5 years of housebound, and the factors related with the outcome. Methods The housebound seniors confirmed 5 years ago in 5 communities in Tangshan were investigated with self-designed questionnaire and elderly depression rating scale again. Results 42.1% of the 147 housebound seniors remained housebound. There was significance between the seniors housebound and non-housebound in the factors of population sociology, such as age, spoused, economic income, housing floor, relationship with their children and social communication, and physical and psychological factors, such as health self-evaluation, loneliness and depression. Conclusion Seniors housebound in community may be reversible with some approaches of intervention.

Objective To examine the changes of matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloproteinase-1 (TIMP-1) in gingival crevicular fluid after conventional mechanical therapy of adult patients with chronic periodontitis. Methods Gingival crevicular fluid samples from 15 patients and 15 healthy subjects were taken with filter paper strips by intra-pocket method initially, respectively, 1 month after scaling and root planning. MMP-9,TIMP-1 levels were measured by immunoblotting. Results MMP-9 levels in patients were redueed significantly after treatment[(2.2±1.4)AU vs (1.2±0.9)AU ]. The clinical parameters were positive correlation with MMP-9 level. TIMP-1 levels in patients were increased significantly after treatment[(1.3±1.2)AU vs (3.7±2.2)AU]. The clinical parameters were negative torrelation with TIMP-1 level. Conclusion MMP-9, TIMP-1 levels can act as objective parameters to evaluate the effect of periodontal therapy.

This article introduces the main content and the procedure of inspecting and evaluating the ethical issues in medical research. The problems existing in ethical issue reviewing in our country were pionted out and suggestion to enhance the ethical inspection were given.

Objective To use self-efficacy theory to intervene patients with chronic obstructive pulmonary disease (COPD),and assess its efficacy on the self management level of COPD patients.Methods 106 COPD patients hospitalized in the respiratory department of a certain hospital from October 2011 to April 2012 were randomly divided into the control group and the intervention group.Each group consisted of 53 patients.Two groups of patients received routine respiratory treatment and nursing.But patients in the intervention group were also systematically intervened under the guidance of Bandura self-efficacy theory.The self-management level of both groups of patients were assessed before the treatment and six weeks after the treatment respectively.Results The self-management level of the intervention group were significantly better than that of the control group after intervention.Conclusions Self-efficacy theory can improve the self-management level of patients with COPD.

Objective To study the disease chart among pre-hospital first aid in Tangshan people'hospital.Methods Prospectively collecting data of pre-hospital first aid 2580 patients from 2006 to 2007,analyzing the data,sex,age,visitingtime,emergency diagnosisand results,etc.Results Among pre-hospital first aid 2580 patients,traf-rice diseases,neurosystem diseases,cerebral infarction,coronary heart disease are the first three diseases.The highest times of pre-hospital first aid are 8:00～10:00,14:00～16:00 and 20:00～22:00.The admission rate is 44.46%.Conclusion Pre-hospital first aid should be based on the data,age,visiting time of the disease,scientifically arranging pre-hospital,training for pre-hospital first aid staff,so,the patients will be the fast and best pre-hospital flint aid.

0.05),the incidence of adverse drug reactions were 3.5% and 2.4%,respectively and the total treatment costs were(4 146.45?282.15)yuan and(4 807.20?318.15)yuan,respectively;and the cost-minimization analysis showed that manicol was the preferred therapy as compared with Glycerol Fructose.In the treatment of the patients with cerebral infarction complicating renal dysfunction,the total effective rates of the two drugs were 80.0% and 93.3%,respectively(P

Objective To study the action of Shuganwan(SHGW) on experimental gastric ulcer in mice. Methods The anti-ga stric ulcer action of SHGW was observed on the gastric ulcer induced by water im mersion stress, reserpine and absolute ethyl alcohol. The effect on gastric secr etion in rats was studied by pyloric ligation. The effect on gastrointestinal mo tility was observed by gastric emptying in mice. The analgesic effect was tested by the hot-plate test and writhing method. Results SHGW m arkedly inhibited gastric ulcer induced by water immersion stress, reserpine and absolute ethyl alcohol. SHGW significantly inhibited the secretion of gastric a cid and pepsin and promoted the secretion of gastric mucus. SHGW markedly delaye d gastric emptying in normal mice and when gastric emptying was stimulated by ne ostigmine. SHGW mildly strengthend the effect of atropine on gastric emptying. S HGW enhanced hot pain threshold and decreased the number of twisting body in mic e. Conclusion Shuganwan may have anti-gastric ulcer ac tion. The mechanism of the action might be associated with its inhibition of the secretion of gastric juice, promotion of the secretion of gastric mucus,inhibit ion of activity of gastric smooth muscle and analgetic effect.

Objective:To study the expression and clinical significance of GPRC5A and SOCS3 in colorectal carcinoma.Methods:SP immunochemical method was performed to detect the expression of GPRCSA and SOCS3 in 45 cases of colorectal carcinoma,25 cases of colorectal adenomas and 22 cases of normal colorectal tissues.Results:1)Expression of GPRC5A in colorectal cancinoma tissue (22.2％) was significantly lower than that in adenomas tissue (52.0％,P＞0.05).The Latter was significantly lower than that in normal colorectal tissue (81.8％,P＜0.05).GPRC5Awas closely related to lymph node metastasis,Duke's stages and the deepness of invasion (P＜0.05).2) Expression of SOCS3 in colorectal cancinoma tissue (24.4％) was significantly lower than that in adenomas tissue (56.0％,P＜0.01).The Latter was significantly lower than that in normal colorectal tissue (86.4％,P＜0.05).SOCS3 was closely related to pathological differentiation,the deepness of invasion,Duke's stages and lymph node metastasis (P＜0.05).3)The expression of GPRC5A was positive correlated with SOCS3 (P＜0.05).Conclusions:The reduced expressions of GPRC5A and SOCS3 may participate in the occurence and development of colorectal carcinorma,suggesting that GPRC5A and SOCS3 may act as biological markers for evaluating the malign degree,prognosis and therapeutic targets of colorectal carcinorma.

Objective Our study is to observe the effects of conjugated equine estrogen (CEE) combined with medroxyprogesterone acetate (MPA) on hemorheology in postmenopausal women in order to evaluate mechanism responsible for the increase in the incidence of cardiovascular disease after menopause and also to provide proper instruction and advice of hormone replacement therapy (HRT) for postmenopausal women Methods 60 healthy postmenopausal women were assigned to 3 groups randomly, 20 cases in each group Group A: CEE 0 625 mg/d+MPA 2 mg/d+calcium carbonate co. (Ca D) 600 mg/d Group B: CEE 0 3 mg/d+MPA 2 mg/d+Ca D 600 mg/d Group C: Ca D 600 mg/d only served as control Measurements of hemorheological parameters were performed before and 6 months after treatment Results After 6 months of HRT, group A: blood viscosity under the shear rate of 94 5 s -1 dropped from (5 23? 0 37) mPa?s to (5 03? 0 43) mPa?s ( P 0 05) Conclusion Both different dosages of CEE have favor effects on blood viscosity and erythrocyte deformabillity, which could play the role in preventing cardiovascular disease in postmenopausal women