Thyroid cancer is the most frequent endocrine malignancy. The histologic subtype of thyroid carcinoma is mainly differentiated thyroid carcinoma. The treatment modality of thyroidectomy followed by 131I and thyroxine-suppressive therapy has been approved and applied widely. A brief introduction and a commentary on this topic is presented in this article.

Levothyroxine monotherapy for primary hypothyroidism has gratifying effects.Doctor should recommend the optimal timing of taking levothyroxine to patients for individualized therapy according to the medical history,the pharmacokinetic characteristics of levothyroxine,and various factors affecting its absorption.After reaching the therapeutic goal,most of patients could live,study,work,marry,and bear as healthy subjects.

Objective To design an image pre-processing system of low-density gene chips based on MATLAB, which can process the colored images by cy3 and cy5 fluorescence staining of low-density chips obtained by the array scanning system. It can filter out noise, enhance the contrast gradient of image, improve the quality of image, and implement the functions of image segmentation, edge detection and region identification. Methods The median filter method of the wavelet was used to implement the function of image denoising and improve the image quality. Edge detection was accomplished by wavelet, combining with edge operators. Image segmentation was developed by genetic algorithms. Results It could reduce the effect of spot, noise and other factors, improve the quality of image, and detect the periphery of image better and the region of sampling point more precisely. It can also effectively separate the valuable weak signal points and background or noise with the system. Conclusion The system can accomplish the functions of image pre-processing of low-density gene chips, and the adopted methods are feasible. It can provide relative accurate data information for future analysis.

Objective To discuss the effect of different cataract ultrasonic emulsification incision on the stability of the tear film after operation.Methods 82 patients (149 eyes) in our hospital from January 2010 to December 2012 were adopted as the research object.Patients were randomly divided into group A (40 cases,72 eyes) and group B(42 cases,77 eyes) used stratified random block method.Patients in group B were treated with anti-eyebrow scleral tunnel incision,and patients in group A were treated with corneal incision.The subjective feeling,tear secretion,tear film break-up time and the corneal incision staining of patients were compared and the results were analyzed between two groups.Results There were statistically significant differences in the subjective feeling of patients,the amount of tear secretion and the tear film breakup time (BUT) between the first day and the seventh day after operation.Conclusions Anti-eyebrow scleral tunnel incision is an ideal incision method for phacoemulsification.It has less impact on the stability of the cornea,and the damage to nerve is also light.

In recent years,the medical imaging technology has developed rapidly.New imaging methods are unceasingly emerging,and the existed imaging modes have been continuously improved.The trends of medical imaging technology have developed from two-dimension imaging to three-dimension imaging,from localized imaging to whole-body imaging,from static imaging to dynamic imaging and from structure to function.This thesis introduces the new imaging methods,such as Molecular Imaging,Near Infrared Imaging and so on.

Object A method was developed for the determination of fatty acid in Fructus Bruceae oil by precolumn derivation HPLC Methods Fatty acids were derivatized with p bromophenacylbromide as derivative and 18 crown 6 as catalyst The method used C 8 Kromasil C 8 (250 mm?4 mm, 5 ?m) column and isocratic acetonitrile water eluent and the internal standard was heptadecanoic acid The detection wavelenghth was 254 nm Column temperature was fixed at room temperature, and the flow rate was 1 3 mL/min Results The standard curves of linoleic, palmitic, oleic, and steraric acid are linear within the range of 0 022—0 330, 0 014—0 213, 0 028—0 416, and 0 012—0 177 ?g, respectively The four fatty acid recoveries are 99 2%, 97 2%, 101 8%, 97 8%, and the RSD are 1 2%, 1 5%, 0 4%, 2 3%, individuslly Conclusion Five fatty acids are separated within 30 minutes during a single run The present method is reliable and relatively simple for the determination of fatty acid in Fruetus Bruceae oil

Objective To investigate the aetiology of acute exacerbations of COPD (AECOPD),and the effects of moxifloxacin in the treatment of AECOPD.Methods Patients with stable COPD based on GOLD criteria were included in the study.Sputum collected at first exacerbation was analyzed for bacteria count and culture.IL-6,IL-8 and TNF-?were measured by enzyme- linked immunosorbent assay (ELISA).Eligible patients were randomized to receive moxifloxacin (400 mg qd for 5 days) or ce- faclor (250 mg q8h for 7 days).Efficacy parameters were evaluated at 7 and 14 days after treatment initiation and 1 year later. Results Of the 46 patients with moderate or severe COPD (male 38,moderate 24),21 (45.65%) were microbiologically evalu- able at baseline.The main pathogen was Haemophilus influenzae (10/21).Clinical efficacy rate was 87.0% in moxifloxacin group and 82.6% in cefaclor group.Bacterial eradication rate was 80.0% and 72.7% respectively.The difference between groups was not statistically significant in terms of clinical or microbiological efficacy.In moxifloxacin arm,the frequency of ex- acerbation was 2.6?1.0,significantly lower than control arm (3.5?1.4,P

Objective To explore diagnosis, treatment and prevention of remnant gallbladder from laparoscopic cholecystectomy (LC). Methods A retrospective analysis was performed for the clinical data of 12 patients treated in our hospital for remnant gallbladder caused by LC from December 1994 to December 2007. Results The occurrent rate of the remnant gallbladder in LC was 0.46%(12/2609). All the 12 patients with remnant gallbladder received surgical operations and 3 of them had remnant gallbladder with stones. Remnant gallbladders in the 12 cases were removed by surgical operations and were cured. Conclusion Ultrosonic or MRI examination is preferable and surgery is the effective treatment for this disease. For avoiding the occurrence of the remnant gallbladder in LC,it is essential to adhere to indications of LC before operation and standards of the surgical procedures.

Objective To clarify the combined ability of viral macrophage inflammatory protein (vMIP) to receptors through comparison research of vMIP binding to chemokine receptors of peripheral blood macrophages(PBMCs). Methods Combined ability of vMIP to receptors was measured with radioligand assay and identified with saturation, kinetic and specificity analyses. Results Kd is 11.1 nmol/L to human receptors of PBMC and 14.3 nmol/L to monkey receptors. The IC50 is 3.4 nmol/L to CCR5 and 4.5 nmol/L to CXCR4. Conclusion vMIP has high affinity with receptors and high specificity to CCR5 and CXCR4.This may be of great significance in the prevention and treatment of inflammation and HIV infection.